Yongfeng Jia

Publications (2)41.23 Total impact

• Source

  Available from: Guangwen Cao

  Article: Identification of common variants in BRCA2 and MAP2K4 for susceptibility to sporadic pancreatic cancer.

  Liming Huang, Chen Wu, Dianke Yu, Chengfeng Wang, Xu Che, Xiaoping Miao, Kan Zhai, Jiang Chang, Guoliang Jiang, Xianghong Yang, [......], Menghong Sun, Wei Cao, Jun Gao, Ying Ma, Xiongwei Zheng, Siu Tim Cheung, Yongfeng Jia, Wen Tan, Tangchun Wu, Dongxin Lin
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  ABSTRACT: Germline mutations in genes that cause hereditary syndromes are highly predisposed to familial pancreatic cancer. However, genetic susceptibility to sporadic pancreatic cancer is largely uncovered. We conducted a two-stage association study on pancreatic cancer that included 981 cases and 1,991 controls in the first stage followed by a second stage (2,603 cases and 2,877 controls). Using an approach based on candidate genes whose roles in pancreatic cancer have been well-known, we identified two new susceptibility loci. rs11571836 located in the BRCA2 3'-untranslated region was significantly associated with lower expression of BRCA2 transcript and increased pancreatic cancer risk [odds ratio (OR)=1.30, 95% confidence interval (CI)=1.14-1.47, P=7.64x10-5] in a recessive manner. rs12939944 located in the MAP2K4 intron was associated with decreased risk (OR=0.82, 95% CI=0.74-0.91, P=0.0001) in a dominant manner. Our results demonstrate for the first time that common variants in BRCA2 and MAP2K4 are susceptibility to sporadic pancreatic cancer.
  Carcinogenesis 01/2013; · 5.70 Impact Factor
• Article: Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.

  Chen Wu, Xiaoping Miao, Liming Huang, Xu Che, Guoliang Jiang, Dianke Yu, Xianghong Yang, Guangwen Cao, Zhibin Hu, Yongjian Zhou, [......], Ying Ma, Xiongwei Zheng, Siu Tim Cheung, Yongfeng Jia, Jian Xu, Wen Tan, Ping Zhao, Tangchun Wu, Chengfeng Wang, Dongxin Lin
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  ABSTRACT: Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.
  Nature Genetics 12/2011; 44(1):62-6. · 35.53 Impact Factor