S G Clarke

Imperial College London, Londinium, England, United Kingdom

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Publications (3)7.28 Total impact

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    ABSTRACT: The impact of anatomical variation and surgical error on excessive wear and loosening of the acetabular component of large diameter metal-on-metal hip arthroplasties was measured using a multi-factorial analysis through 112 different simulations. Each surgical scenario was subject to eight different daily loading activities using finite element analysis. Excessive wear appears to be predominantly dependent on cup orientation, with inclination error having a higher influence than version error, according to the study findings. Acetabular cup loosening, as inferred from initial implant stability, appears to depend predominantly on factors concerning the area of cup-bone contact, specifically the level of cup seating achieved and the individual patient's anatomy. The extent of press fit obtained at time of surgery did not appear to influence either mechanism of failure in this study.
    Journal of biomechanics 04/2012; 45(9):1698-704. · 2.66 Impact Factor
  • S G Clarke, A T M Phillips, A M J Bull
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    ABSTRACT: Finite element (FE) analysis provides an useful tool with which to analyze the potential performance of implantations in a variety of surgical, patient and design scenarios. To enable the use of FE analysis in the investigation of such implants, models must be experimentally validated. Validation of a pelvic model with an implanted press-fit cup in terms of micromotion and strain is presented here. A new method of micromotion has been introduced to better describe the overall movement of the cup within the pelvis. The method uses a digitizing arm to monitor the relative movement between markers on the cup and the surrounding acetabulum. FE analysis was used to replicate an experimental set up using a synthetic hemi-pelvis with a press-fitted all-metal cup, subject to the maximum loading observed during normal walking. The work presented here has confirmed the ability of FE models to accurately describe the mechanical performance of the press-fitted acetabulum and surrounding bone under typical loading conditions in terms of micromotion and strain distribution, but has demonstrated limitations in its ability to predict numerical micromotion values. A promising digitizing technique for measuring acetabular micromotions has also been introduced.
    Annals of Biomedical Engineering 02/2012; 40(7):1586-96. · 3.23 Impact Factor
  • S G Clarke, A T M Phillips, A M J Bull
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    ABSTRACT: To enable large-scale multi-factorial finite element (FE) studies, the FE models used must be as computationally efficient as is feasible, while maintaining a suitable level of definition. The present study seeks to find an optimum level of model complexity for use in such large-scale studies by investigating which model attributes are most influential over the chosen model outputs of principal stress and strain in the intact acetabulum. A multi-factorial sensitivity study was carried out using 128 FE models, representing combinations of the following variables: bone stiffness distribution, imposed muscle loading, boundary condition location, hip joint contact conditions and patient's bone anatomy. The relative sensitivity of each input factor was analysed, and it was concluded that the optimum level of model definition must include CT-dependent trabecular bone properties and a sliding interface at the hip joint. It was found that it was not essential to describe the ligamentous sacroiliac and pubic symphysis joints; these could be rigidly fixed in space; and for the normal walking load case, muscle forces may be neglected. It was also concluded that a variety of bone anatomies should be included in a multi-factorial analysis if results are to be inferred for a wider population.
    Computer Methods in Biomechanics and Biomedical Engineering 12/2011; · 1.39 Impact Factor