Publications (2)8.86 Total impact
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Article: Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation.
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ABSTRACT: Background. Anticoagulation by standard dosage of an inhibitor of thrombin generation presupposes predictable pharmacokinetics and pharmacodynamics of the anticoagulant. We determined the inter-individual variation of the effect on thrombin generation of a fixed concentration of direct - and antithrombin-mediated inhibitors of thrombin and factor Xa. Design and Methods. Thrombin generation was determined by calibrated automated thrombinography in platelet poor plasma of 44 apparently healthy subjects spiked with a fixed concentration of otamixaban, melagatran, unfractionated heparin, dermatan sulfate and pentasaccharide. The variability of the inhibitory effect of the different anticoagulants within the population was determined using the coefficient of variation, i.e. the standard deviation expressed as a percentage of the mean. Results. The inter-individual coefficient of variation of the endogenous thrombin potential and peak height before inhibition were 18% and 16%, respectively and became 20%-24% and 24%-43% after inhibition. The average inhibition of endogenous thrombin potential and peak height (ETP, peak) brought about by the anticoagulants was respectively: otamixaban (27%, 83%), melagatran (56%, 63%), unfractionated heparin (43%, 58%), dermatan sulfate (68%, 57%) and pentasaccharide (25%, 67%). Conclusions. This study demonstrates that the addition of a fixed concentration of any type of anticoagulant tested causes an inhibition that is highly variable from one individual to another. In this respect there is no difference between direct inhibitors of thrombin and factor Xa and heparin(-likes) acting on the same factors.Haematologica 10/2012; · 6.42 Impact Factor -
Article: No effect of ethanol intake on thrombin generation parameters.
Thrombosis Research 11/2011; 129(4):530-1. · 2.44 Impact Factor
