Minchan Yan

Taizhou Central Hospital, T’ai-hsien-ch’eng, Jiangsu Sheng, China

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Publications (2)7.25 Total impact

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    ABSTRACT: Data on early human fetal exposure to polybrominated diphenyl ethers (PBDEs) is limited. However, early pregnancy, in particular the first trimester, is critical for fetal development. We investigated exposure to PBDEs and placental transfer during early pregnancy by analyzing PBDEs in paired aborted fetuses (n=65), placentas (n=65), and maternal blood samples (n=31) at 10-13 weeks gestation, which were collected in a hospital near electronic wastes (e-wastes) recycling sites in Taizhou, China. Mean total PBDE (ΣPBDE) concentrations were 4.46, 7.90, and 15.7 ng/g lipid weight (lw) in the fetuses, placentas, and blood, respectively. The three matrices had roughly similar PBDE congener profiles, dominated by BDE-209, -197, -153, -47, and -28. Significant correlations were found between ΣPBDE concentrations in the paired matrices. Comparing the concentration ratios between the paired samples, we observed significantly higher Fetus/Blood and Fetus/Placenta ratios for BDE-28, -99, and -47 than for BDE-197, -209, and -153, while opposite results were found in Placenta/Blood ratios. Our results indicate that PBDEs can enter the fetus during the first trimester, and low brominated congeners cross the placenta more easily than high brominated congeners, which tend to remain in the placenta. This phenomenon is consistent with findings at the end of pregnancy.
    Environmental Science & Technology 04/2013; · 5.48 Impact Factor
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    ABSTRACT: Polybrominated diphenyl ethers (PBDEs) as ubiquitous persistent organic pollutants have attracted much attention in recent years. Exposure to PBDEs could induce a high health risk for children. The aim of this study was to investigate the PBDEs exposure of children (9-12 years) from Taizhou, China. Fifty-eight blood samples were collected in one school in a mountainous area in Taizhou. The concentrations of sigma9PBDEs (sum of BDE-28, -47, -99, -100, -153, -154, -183, -197 and -209) ranged from 2.66 to 33.9 ng/g lipid wet (lw) with a median of 7.22 ng/g lw. These concentrations were lower than those of children in USA, but close to European and Asian general population levels. The results showed that children in Taizhou countryside were at a low level of PBDEs exposure. The predominant congener was BDE-209, followed by BDE-28, -47, -197 and -153. High abundance of BDE-209 was consistent with the pollution background of PBDEs in China characterized by high brominated congeners as main pollutants.
    Journal of Environmental Sciences 01/2011; 23(7):1199-204. · 1.77 Impact Factor