Pengzhou Li

Publications (2)3.29 Total impact

• Article: Effect of Laparoscopic Roux-en-Y Gastroenterostomy with BMI < 35 kg/m(2) in Type 2 Diabetes Mellitus.

  Liyong Zhu, Zhaohui Mo, Xiangwu Yang, Shengping Liu, Guohui Wang, Pengzhou Li, Juan Tan, Fei Ye, Jeff Strain, Ibrahim Im, Shaihong Zhu
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  ABSTRACT: Roux-en-Y gastric bypass (RGB) has been endorsed by the "First World Congress on International Therapies for Type 2 diabetes" as a possible therapeutic option in patients with type 2 diabetes with a body mass index (BMI) of less than 35 kg/m(2). In the present study, we assessed the improvement in clinical indicators associated with laparoscopic Roux-en-Y gastric bypass (LRYGB) in patients with non-obese type 2 diabetes mellitus (T2DM). LRYGB was performed in 30 T2DM patients with a BMI <35 kg/m(2). The patients were followed up for 1 year. Pre- and postoperative changes in BMI, waist circumference, and biochemical indicators including fasting plasma glucose and glycosylated hemoglobin were recorded. Significant reduction in glycosylated hemoglobin from 8.02 ± 1.77 to 5.59 ± 1.02 % (p < 0.05) at 12 months was noted. Diabetes was completely resolved in nine cases, resulting in discontinuation of diabetes-related medication. No significant surgical complications occurred. LRYGB is beneficial for non-obese T2DM patients in China.
  Obesity Surgery 06/2012; 22(10):1562-7. · 3.29 Impact Factor
• Article: [Glucose-dependent insulinotropic peptide in Type 2 diabetes after gastric bypass surgery].

  Pengzhou Li, Shaihong Zhu, Dawei Zhang, Yan Liu, Guohui Wang, Liyong Zhu, Fei Ye
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  ABSTRACT: Glucose-dependent insulinotropic peptide (GIP),the incretins,is synthesized and released from the duodenum and proximal jejunum. Continual high-fat diet powerfully stimulated GIP secretion,leading to obesity and harmful lipid deposition in islet cells and peripheral tissues,and giving rise to insulin resistance and major disturbances in the secretion of insulin. We can improve Type 2 diabetes by compromising GIP action. The exclusion of proximal small intestine and reduction of GIP secretion may be the important reasons for Type 2 diabetes after gastric bypass surgery.
  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 10/2011; 36(10):1017-20.