Juan Sebastián Castillo

Publications (2)0.99 Total impact

• Article: [Diagnostic methods in candidemia: a systematic review of literature with meta-analysis].

  Jorge Alberto Cortés, Alejandro Concha M, Luis Eduardo Cediel T, Juan Sebastián Castillo
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  ABSTRACT: Candidemia is a disease with high morbidity and mortality especially in critical care patients. Early diagnosis enables early treatment. Objectives: To conduct a systematic review of the literature in order to establish the best laboratory tests for the diagnosis of candidemia in critical patients. Materials and Methods: We conducted a systematic review of available literature in PubMed. Serological studies were subjected to meta-analysis in metadisk-Beta 1.1.1. Results: 4 studies of 1286 reviewed were included. Three were about serological tests and one about molecular testing (RT-PCR). The sensitivity and specificity for RT-PCR, antibody testing and antigen and antibody tests were 87% and 100%, 47.5% and 82.6%, 96% and 81%, respectively. Diagnostic Odds Ratio of antigenemia was 1.51 (95% CI = 0,032-70,964, p = 0.001). Conclusions: RT-PCR has better diagnostic performance, measuring antigenemia plus antibodies improves sensitivity, specificity, LR + and LR-- . There is insufficient evidence to support this.
  Revista chilena de infectologia: organo oficial de la Sociedad Chilena de Infectologia 10/2011; 28(5):423-8. · 0.45 Impact Factor
• Article: [Systematic review of antimicrobial resistance among Gram positive cocci in hospitals in Colombia].

  Carmelo José Espinosa, Jorge Alberto Cortés, Juan Sebastián Castillo, Aura Lucía Leal
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  ABSTRACT: Bacterial resistance is a public health problem worldwide whose proper management requires knowledge of its presence and its behavior in each region and country. A survey of the medical literature was conducted to identify levels of resistance to antibiotic markers in Gram positive bacterial isolates from Colombian hospitals. A systematic review of the literature included articles indexed in MEDLINE and LILACS. A manual search was made of Colombian scientific journals and other infectious disease literature not available electronically. A total of 34 observational studies were located, including a series of consecutive reports initiated in 2001. Most of the reports came from the city of Bogota. The rate of methicillin resistance for Staphylococcus aureus and coagulase-negative staphylococci in non intensive care unit isolates ranged between 35%-50% and 72%-76%, respectively. Resistance in intensive care unit isolates had a range between 35%-71% and 74%-83%, respectively. The rate of vancomycin-resistant Enterococcus faecium averaged less than 20% over the years but with large annual variation . Resistance markers appeared in high frequency among Gram positive isolates identified in hospitals in major Colombian cities.
  Biomédica: revista del Instituto Nacional de Salud 03/2011; 31(1):27-34. · 0.55 Impact Factor