Sandy H J Hsu

Publications (3)16.02 Total impact

• Article: Association between levels of serum perfluorooctane sulfate and carotid artery intima-media thickness in adolescents and young adults.

  Chien-Yu Lin, Lian-Yu Lin, Ting-Wen Wen, Guang-Wen Lien, Kuo-Liong Chien, Sandy H J Hsu, Chien-Chang Liao, Fung-Chang Sung, Pau-Chung Chen, Ta-Chen Su
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  ABSTRACT: BACKGROUND: Perfluorinated chemicals (PFCs) have been widely used for years in a variety of products worldwide. Although epidemiological findings have shown that PFC levels are positively associated with cholesterol and uric acid levels, it is unknown whether PFCs are associated with atherosclerosis. METHODS: We recruited 664 subjects (12-30years) from a population-based sample of adolescents and young adults based on a mass urine screening to determine the relationship between serum levels of PFCs and carotid intima-media thickness (CIMT). RESULTS: The median concentrations and ranges of perfluorooctanoic acid (PFOA), perfluorooctane sulfate (PFOS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFUA) were 3.49 (0.75-52.2) ng/mL, 8.65 (0.11-85.90) ng/mL, 0.38 (0.38-25.4) ng/mL, and 6.59 (1.50-105.7) ng/mL, respectively. After controlling for age, gender, smoking status, systolic blood pressure, body mass index, low-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, and homeostasis model assessment of insulin resistance, multiple linear regression analysis revealed that CIMT increased significantly across quartiles of PFOS (0.434mm, 0.446mm, 0.458mm, 0.451mm; P for trend <0.001). Subpopulation analysis showed the association between PFOS and CIMT was more evident and significant in females, non-smokers, subjects of age 12-19years, BMI<24, and those with APOE genotype of E2 carrier and E3/E3. CONCLUSIONS: Higher serum concentrations of PFOS were associated with an increase of carotid IMT in this cohort of adolescents and young adults. Further studies are warranted to clarify the causal relationship between PFOS and atherosclerosis.
  International journal of cardiology 05/2013; · 7.08 Impact Factor
• Article: The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults.

  Chien-Yu Lin, Li-Li Wen, Lian-Yu Lin, Ting-Wen Wen, Guang-Wen Lien, Sandy H J Hsu, Kuo-Liong Chien, Chien-Chang Liao, Fung-Chang Sung, Pau-Chung Chen, Ta-Chen Su
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  ABSTRACT: Perfluorinated chemicals (PFCs) have been widely used in a variety of products worldwide for years. However, the effect of PFCs on thyroid function has not yet been clearly defined. We recruited 567 subjects (aged 12-30 years) in a population-based cohort of adolescents and young adults with abnormal urinalysis in the childhood to determine the relationship between serum level of PFCs and the levels of serum free thyroxine (T4) and thyroid stimulating hormone (TSH). The geometric means and geometric standard deviation concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) were 2.67 (2.96)ng/ml, 7.78 (2.42)ng/ml, 1.01 (3.48)ng/ml and 5.81 (2.92)ng/ml, respectively. Differences in the levels of free T4 and TSH across different categories of PFOA, PFOS and PFUA were insignificant. After controlling for confounding factors, multiple linear regression analyses revealed mean serum level of free T4 increased significantly across categories (<60th, 60-89 and >90th percentiles) of PFNA (P for trend =0.012 in the full model). The association between PFNA and free T4 was more significant in male subjects in age group 20-30, active smokers and in those with higher body mass index in stratified analysis. Serum concentrations of PFNA were associated with serum free T4 levels in adolescents and young adults.
  Journal of hazardous materials 11/2012; · 4.14 Impact Factor
• Article: Associations between levels of serum perfluorinated chemicals and adiponectin in a young hypertension cohort in Taiwan.

  Chien-Yu Lin, Li Li Wen, Lian-Yu Lin, Ting-Wen Wen, Guang-Wen Lien, Chia-Yang Chen, Sandy H J Hsu, Kuo-Liong Chien, Fung-Chang Sung, Pau-Chung Chen, Ta-Chen Su
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  ABSTRACT: In animals, perfluorinated chemicals (PFCs), specifically perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS), function as peroxisome proliferator-activated receptor (PPAR) alpha agonists. However, the relevance of animal (primarily rodent) data to humans is unresolved. While plasma adiponectin level is very responsive to PPAR gamma agonist drugs, it has not been determined whether adiponectin level is related to serum PFCs concentrations. In the present study, 287 subjects (12-30 years of age) were recruited to determine the relationship between serum level of PFCs and serum level of adiponectin. The results showed males had higher serum PFOS concentrations than females and that those with metabolic syndrome had lower serum PFOA than controls. Besides, it showed regional elevations of the perfluoroundecanoic acid (PFUA) (median concentration: 7.11 ng/mL) in the study subjects. No relationship of PFOA, PFOS, PFUA, and the sum of all four PFCs was found to glucose homeostasis, adiponectin level, lipid profile, and inflammatory markers. The median and the range of perfluorononanoic acid (PFNA) concentration (in ng/mL; for four categories corresponding to the <50, 50-74, 75-89, and ≥90th percentiles) were 0.38 (0.38-1.68), 3.22 (1.73-4.65), 5.85 (4.75-8.29), 10.56 (8.40-25.40), respectively. After controlling for confounding factors, multiple linear regression analysis revealed that the mean natural log-transformed level of adiponectin increased significantly across categories of PFNA (in ng/mL; 8.78, 8.73, 9.06, 9.36; P for trend = 0.010 in the full model). In conclusion, higher serum PFNA concentration is associated with elevated serum adiponectin concentration.
  Environmental Science & Technology 11/2011; 45(24):10691-8. · 4.80 Impact Factor