Jung Eun Lee

University of Washington Seattle, Seattle, Washington, United States

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Publications (269)732.39 Total impact

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    ABSTRACT: Rubus Coreanus Miquel (RCM), used as a traditional Korean medicine, reduces chronic inflammatory diseases such as cancer and rheumatoid arthritis. However, its mechanism has not been elucidated. In this study, we examine the anti-inflammatory effects of RCM and their possible mechanisms using RAW 264.7 cells.
    Nutrition research and practice 10/2014; 8(5):501-8. · 0.97 Impact Factor
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    ABSTRACT: Abstract Bortezomib combination chemotherapy appears to be active in light chain (AL) amyloidosis with high rates of hematologic and organ response. We report a retrospective evaluation of the clinical outcome of treatment with bortezomib, melphalan, and prednisolone (VMP) as first-line chemotherapy in patients with AL amyloidosis who were ineligible for autologous stem cell transplant. Among the 19 patients included in this study, 90% had two or more involved organs and most of the patients had advanced stage AL amyloidosis (84% with 2004 Mayo Stage III and 92% with 2012 Mayo Stage III or IV). Sixteen (84%) patients had a hematologic response, including seven (37%) with complete response, with time to response of 1-3 months. Cardiac and renal responses were observed in 44% and 33% of patients, respectively. Estimated 2-year survival is 39%, and 5 patients (26%) died during therapy. The common grade 3-4 adverse events were thrombocytopenia, diarrhea and pneumonia. A once-weekly bortezomib is more feasible than twice-weekly regimen. Our results suggest that triplet regimen of VMP appears to be an effective regimen in advanced AL amyloidosis ,but benefits in the patients with multi-organ dysfunction remain to be proven.
    Amyloid. 09/2014;
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    ABSTRACT: Endothelial dysfunction is implicated in increased cardiovascular risk in nondialyzed population. However, the prognostic impact of endothelial dysfunction on cardiovascular outcome has not been investigated in peritoneal dialysis (PD) patients.We prospectively determined endothelial function by brachial artery endothelium-dependent vasodilation (flow-mediated dilation [FMD]) in 143 nondiabetic PD patients and 32 controls. Primary outcome was a major adverse cardiac and cerebrovascular event (MACCE).Brachial FMD was significantly lower in PD patients than in controls (2.9% [1.3-4.7] vs 6.2% [5.4-8.3], P < 0.001). During a mean follow-up of 42 months, primary outcome was observed in 25 patients (17.5%). When patients were dichotomized by the median value of FMD (2.9%), incidence rates of MACCEs were significantly higher in the group with lower FMD compared with higher FMD (7.2 vs 3.0/100 person-years, P = 0.03). In multivariate Cox analysis, low FMD (≤2.9%) was a significant independent predictor of MACCEs (hazard ratio = 2.73, 95% confidence interval = 1.03-7.22, P = 0.04). Furthermore, multivariate fractional polynomial analysis showed that the risk of MACCE decreased steadily with higher FMD values.Impaired brachial FMD was a significant independent predictor of MACCEs in PD patients. Estimating endothelial dysfunction by brachial FMD could be useful for stratifying cardiovascular risk in these patients.
    Medicine. 09/2014; 93(11):e73.
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    ABSTRACT: Background Reduction in renal mass after unilateral nephrectomy causes functional and structural changes in the remaining kidney. We investigated the association between predonation serum uric acid (SUA) concentration and the change in renal function after living kidney donation.Methods This retrospective study included 413 living kidney donors from a single center. We collected medical history and laboratory findings at baseline and 6 months after donation. Renal function was assessed by calculating the estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration equation. Main outcomes were the percentage change in eGFR from before to 6 months after donation and the percentage of patients whose eGFR decreased by >25% after donation compared with the predonation baseline value.ResultsMean age was 40 ± 11 years, and eGFR was 106 ± 14 ml/min/1.73 m2. In women, the SUA concentration was linearly associated with the change in eGFR after donation independently of baseline eGFR (standardized coefficient – 0.16, P = 0.04). Multiple logistic analysis showed that a 59.5 μmol/l increase in baseline SUA concentration was associated with a 1.7-fold higher risk of a >25% decrease in eGFR after donor nephrectomy [95% confidence interval, 1.2–2.5; P = 0.007] in women. In contrast, SUA concentration was not an independent risk factor of decrease in eGFR after donor nephrectomy in men.Conclusions Predonation SUA concentration is associated independently with the change in renal function after donor nephrectomy in women but not in men.
    Internal Medicine Journal 09/2014; · 1.82 Impact Factor
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    ABSTRACT: We aimed to evaluate the reproducibility and validity of the newly developed FFQ for the Korean National Health and Nutrition Examination Survey (KNHANES) and to estimate the measure's calibration factors.
    Public health nutrition. 08/2014;
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    ABSTRACT: Human umbilical cord blood-derived stem cells (HUCB-MSCs) have been studied in several models of immune-mediated disease because of their unique immunomodulatory properties. We hypothesized that HUCB-MSCs could suppress the inflammatory response in postischemic kidneys and attenuate early renal injury. In 8-10-week-old male C57BL/6 mice, bilateral ischemia-reperfusion injury (IRI) surgery was performed and 1x106 HUCB-MSCs were injected intraperitoneally 24 h prior to surgery and during reperfusion. Renal functional and histological changes, HUCB-MSC trafficking, leukocyte infiltration, and cytokine expression were analyzed. Renal functional decline and tubular injury following IRI were attenuated by HUCB-MSC treatment. PKH26-labeled HUCB-MSCs trafficked into the postischemic kidney. Although numbers of CD45-positive leukocytes in the postischemic kidney were comparable between groups, the expression of interferon-γ in the postischemic kidney was suppressed by HUCB-MSC treatment. The rapid decrease in intrarenal vascular endothelial growth factor (VEGF) following IRI was markedly mitigated by HUCB-MSC treatment. In inflammatory conditions simulated in a cell-culture experiment, VEGF secretion from HUCB-MSCs was substantially enhanced. VEGF inhibitor abolished the renoprotective effect of HUCB-MSCs after IRI. Flow cytometry analysis revealed the decreased infiltration of NKT cells and increased number of regulatory T cells in the postischemic kidneys. And, these effects of HUCB-MSCs on the kidney infiltrating mononuclear cells after IRI were attenuated by VEGF inhibitor. HUCB-MSCs attenuated renal injury in mice in the early injury phase following IRI, mainly by humoral effects and secretion of VEGF. Our results suggest a promising role for HUCB-MSCs in the treatment of renal IRI.
    American journal of physiology. Renal physiology 08/2014; · 3.61 Impact Factor
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    ABSTRACT: Bacterial endocarditis secondary to jet streams from a congenital heart defect without valvular involvement is very rare, especially in adult patients. We report an unusual case of a 32-year-old woman with a previously known unrepaired ventricular septal defect (VSD) who presented with intermittent fever and chills after dental treatment and was diagnosed with isolated right-sided mural infective endocarditis associated with a muscular-type VSD. Echocardiography revealed a low echogenic, mobile vegetation along the right ventricular outflow tract (RVOT) free wall and a small-sized muscular-type VSD. The patient's blood culture grew Streptococcus viridians. After 3 weeks of antibiotic treatment, VSD patch closure was performed, and the vegetation on the RVOT endomyocardium was removed. © 2014 S. Karger AG, Basel.
    Cardiology 08/2014; 129(1):65-68. · 1.52 Impact Factor
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    ABSTRACT: The purpose of the present study was to identify a predictive marker associated with tumor progression or recurrence. We investigated the expression of p53, Ki-67, Bax, Bcl-2, vascular endothelial growth factor (VEGF)-A, VEGFR-1, VEGFR-2 and neuropilin-1 (NRP-1) in pituitary adenomas (PAs) with/without tumor progression during follow-up periods. We compared the expression of these molecules in primary and recurrent specimens to identify a predictive marker associated with tumor progression. Nineteen patients had no progression for more than 5-years of follow-up. Nine patients had tumor progression within 5 years of their first transsphenoidal surgery (TSS) surgery and underwent re-TSS for treating progression of adenoma. Tumor size was larger and involvement of the cavernous sinus was more frequent in the progression group than these variables in the no progression group. A strong association was observed between NRP-1 expression and tumor progression. No significant risk for developing tumor progression was associated with Ki-67, p53, Bax, Bcl-2, VEGFR-1, VEGFR-2, or VEGF-A expression. Four of nine patients showed strong NRP-1 immunoreactivity in progression specimens. Negative NRP-1 immunoreactivity in the initial specimens was converted into strong positivity in the progression specimens of five patients. NRP-1 could be a relevant PA marker of progression and could be a potential target for medical therapy.
    Oncology reports. 08/2014;
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    ABSTRACT: Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver, glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stellate cells (HSCs). In the present study, the effects of Ex-4 on GLUT4 expression were determined in the liver of ob/ob mice. Ob/ob mice were treated with Ex-4 for 10 weeks. Serum metabolic parameters, hepatic triglyceride levels, and liver tissues were evaluated for hepatic steatosis. The weights of the whole body and liver in ob/ob mice were reduced by long-term Ex-4 treatment. Serum metabolic parameters, hepatic steatosis, and hepatic fibrosis in ob/ob mice were reduced by Ex-4. Particularly, Ex-4 improved hepatic steatosis by enhancing GLUT4 via GLP-1R activation in ob/ob mice. Ex-4 treatment also inhibited hepatic fibrosis by decreasing expression of connective tissue growth factor in HSCs of ob/ob mice. Our data suggest that GLP-1 agonists exert a protective effect on hepatic steatosis and fibrosis in obesity and type 2 diabetes.
    08/2014; 18(4):333-9.
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    ABSTRACT: Low cytotoxicity and high cellular gene delivery capability are among the most important prerequisites for the selection of a non-viral carrier. Although calcium phosphate (CAP) nanoparticles have been long used for animal cell transfection, its rapid and uncontrollable crystal growth and lack of tissue specificity are among the most challenging problems that limit its use in the clinic. In this study, we report the development of CAP nanoparticles stabilized by a conjugate of the mussel-inspired adhesive molecule, 3,4-dihydroxy-L-phenylalanine (dopa), and a nontoxic hydrophilic natural polymer, hyaluronic acid (HA), for targeted siRNA delivery to tumors. CAP/siRNA/dopa-HA can form compact nanoparticles that effectively protect siRNA from enzymatic degradation despite the structural drawbacks of siRNA, such as low charge density and short and rigid structure. In addition, stabilized CAP nanoparticles were able to maintain their colloidal stability in a physiological salt condition for over a week. The superior ability of CAP/siRNA/dopa-HA to maintain the integrity of encapsulated siRNA and the stability in solution of the nanoparticles allow this formulation to achieve improved intratumoral accumulation of siRNA and a high level of target gene silencing in solid tumors after systemic administration. Considering its biocompatibility, transfection efficacy, and tumor targeting capability, this stabilized calcium phosphate nanoparticle-based gene delivery platform should be considered a promising candidate carrier for systemic siRNA delivery and targeted cancer therapy.
    Journal of controlled release : official journal of the Controlled Release Society. 07/2014;
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    ABSTRACT: In this randomized controlled trial, we examined the effects of a 3-month therapeutic lifestyle modification (TLM) intervention on knowledge, self-efficacy, and health behaviors related to bone health in postmenopausal women in rural Korea. Forty-one women ages 45 or older were randomly assigned to either the intervention (n = 21) or control (n = 20) group. The intervention group completed a 12-week, 24-session TLM program of individualized health monitoring, group health education, exercise, and calcium-vitamin D supplementation. Compared with the control group, the intervention group showed significant increases in knowledge and self-efficacy and improvement in diet and exercise after 12 weeks, providing evidence that a comprehensive TLM program can be effective in improving health behaviors to maintain bone health in women at high risk of osteoporosis. © 2014 Wiley Periodicals, Inc.
    Research in Nursing & Health 06/2014; · 2.18 Impact Factor
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    ABSTRACT: Living-unrelated donors (LURD) have been widely used for kidney transplantation (KT). We retrospectively reviewed 779 patients who underwent living-donor KT from 2000 to 2012, to compare outcomes of 264 KT from LURD and 515 from living-related donors (LRD), and to identify risk factors for living KT. Median follow-up was 67 months. Mean donor age, total HLA mismatches and HLA-DR mismatches were higher, and mean estimated glomerular filtration rate (eGFR) was lower in LURD. Acute rejection (AR)-free survival (P=0.018) and graft survival (P=0.025) were lower for LURD than LRD whereas patient survival rate was comparable. Cox-regression analysis showed HLA-DR mismatches (OR 1.75 for 1 mismatch; OR 2.19 for 2 mismatches), recipient age≤42 years and donor age>50 years were significant risk factors for acute rejection. For graft survival, AR and donor eGFR (OR 1.90, P=0.035) were significant. We also identified significant impact of recipient age>50 years and diabetes for patient survival. However, KT from LURD was not significant risk factor for AR (P=0.368), graft survival (P=0.205) and patient survival (P=0.836). Our data suggest that donor eGFR and donor age are independent risk factors for clinical outcomes of living KT, which can be related with poor outcome of KT from LURD. This article is protected by copyright. All rights reserved.
    Clinical Transplantation 05/2014; · 1.63 Impact Factor
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    ABSTRACT: To evaluate the lateral transmalleolar (LTM) approach for a displaced postero-lateral fragments of a posterior malleolus fracture (PMF).
    Journal of orthopaedic trauma. 05/2014;
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    ABSTRACT: To evaluate the association between body mass index (BMI, kg/m(2)) and incidence of biliary tract disease. We performed a systematic review and a meta-analysis of prospective studies by searching the database of PubMed and EMBASE published up to December 31, 2013. Outcome of interest was disease of biliary tract system (gallbladder, extrahepatic bile duct and Ampullar of Vater). We used a random-effects model to combine the study-specific relative risks (RRs) and 95% confidence intervals (95% CIs) from 22 prospective studies. We examined whether BMI was associated with a higher risk of biliary tract disease in a combined analysis. The positive association was stronger for non-cancer biliary tract disease than biliary tract cancer; combined RRs (95% CIs) comparing the top with bottom categories were 1.40 (1.15-1.65) for biliary tract cancer and 2.75 (2.35-3.15) for non-cancer biliary tract disease (P for difference<0.001). For non-cancer biliary tract disease, combined RRs (95% CIs) comparing the top with bottom categories were 3.21 (2.48-3.93) for women and 2.01 (1.66-2.37) for men (P for difference=0.04). Obesity is associated with higher risks of biliary tract cancer and, to a greater extent, non-cancer biliary tract disease.
    Preventive Medicine 04/2014; · 3.50 Impact Factor
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    ABSTRACT: Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest. We performed pooled analyses of data from 1,049,929 participants in 21 cohorts in Asia to quantify the risks of total and cause-specific mortality associated with tobacco smoking using adjusted hazard ratios and their 95% confidence intervals. We then estimated smoking-related deaths among adults aged ≥45 y in 2004 in Bangladesh, India, mainland China, Japan, Republic of Korea, Singapore, and Taiwan-accounting for ∼71% of Asia's total population. An approximately 1.44-fold (95% CI = 1.37-1.51) and 1.48-fold (1.38-1.58) elevated risk of death from any cause was found in male and female ever-smokers, respectively. In 2004, active tobacco smoking accounted for approximately 15.8% (95% CI = 14.3%-17.2%) and 3.3% (2.6%-4.0%) of deaths, respectively, in men and women aged ≥45 y in the seven countries/regions combined, with a total number of estimated deaths of ∼1,575,500 (95% CI = 1,398,000-1,744,700). Among men, approximately 11.4%, 30.5%, and 19.8% of deaths due to cardiovascular diseases, cancer, and respiratory diseases, respectively, were attributable to tobacco smoking. Corresponding proportions for East Asian women were 3.7%, 4.6%, and 1.7%, respectively. The strongest association with tobacco smoking was found for lung cancer: a 3- to 4-fold elevated risk, accounting for 60.5% and 16.7% of lung cancer deaths, respectively, in Asian men and East Asian women aged ≥45 y. Tobacco smoking is associated with a substantially elevated risk of mortality, accounting for approximately 2 million deaths in adults aged ≥45 y throughout Asia in 2004. It is likely that smoking-related deaths in Asia will continue to rise over the next few decades if no effective smoking control programs are implemented. Please see later in the article for the Editors' Summary.
    PLoS Medicine 04/2014; 11(4):e1001631. · 15.25 Impact Factor
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    ABSTRACT: Single crystalline silicon nanomembranes (Si NMs) represent a critically important class of material for high performance forms of electronics that are capable of complete, controlled dissolution when immersed in water and/or bio-fluids, sometimes referred to as a type of 'transient' electronics. The results reported here include the kinetics of hydrolysis of Si NMs in bio-fluids and various aqueous solutions through a range of relevant pH values and temperatures, as well as the effects of dopant type and concentration. In vitro and in vivo investigations of Si NMs and other transient electronic materials demonstrate biocompatibility and bio-resorption, thereby suggesting potential for envisioned applications in active, biodegradable electronic implants.
    ACS Nano 03/2014; · 12.03 Impact Factor
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    ABSTRACT: Inflammation is a key mediator of renal ischemia‑reperfusion (IR) injury. Gender disparities have been reported in acute and chronic kidney disease. In particular, males are considered to be more susceptible to renal ischemic injury compared with females according to animal studies. The purpose of the present study was to investigate the effect of gender on the renal inflammatory response following acute renal IR injury in mice. Experiments were performed in male and female C57BL/6 mice. Two weeks prior to the study, castration or ovariectomy were performed and testosterone propionate (100 µg/kg) or 17β‑estradiol (100 µg/kg) was injected. Acute kidney injury (AKI) was induced by bilateral clamping of the renal pedicle for 23 min. Histological examination, western blot analysis and quantitative polymerase chain reaction were performed. In the acute renal IR injury model, the female mice were more resistant to kidney injury compared with the male mice. However, castration of the male mice reduced the levels of IR‑induced tubular injury and macrophage infiltration compared with those in the injured male mice. Supplementation of testosterone reversed this protective effect in the male AKI model. Depletion of estrogen in the female mice increased the levels of IR‑induced tubular injury and macrophage infiltration compared with those in the injured female mice. However, supplementation of estrogen in the ovariectomized female mice attenuated the IR‑induced tubular injury and reduced the levels of macrophage infiltration. The expression levels of inflammatory cytokines, including tumor necrosis factor‑α, monocyte chemotactic protein‑1, interferon‑γ and chemokine (C‑C motif) ligand 17, were elevated in the male AKI mice compared with those in the control male mice, and were attenuated by castration. Estrogen depletion in the female mice significantly increased the expression levels of the renal inflammatory cytokines compared with those in the injured female mice, and were attenuated by estrogen supplementation in the ovariectomized female mice. These results suggested that the male gender confers greater susceptibility to IR renal injury due to an enhanced inflammatory response.
    Molecular Medicine Reports 03/2014; · 1.17 Impact Factor
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    ABSTRACT: Along with MHC class I (MHCI), 2B4 provides non-redundant NK-cell inhibition in mice. The immunoregulatory role of 2B4 has been increasingly appreciated in models of tumor and viral infection, however, the interactions among 2B4, MHCI, and other activating NK-cell receptors remain uncertain. Here, we dissect the influence of two distinct inhibitory pathways in modulating NK-cell-mediated control of tumors expressing strong activating ligands, including RAE-1γ. In vitro cytotoxicity and in vivo peritoneal clearance assays using MHCI(+) CD48(+) (RMA-neo), MHCI(+) CD48(+) RAE-1γ (RMA-RAE-1γ), MHCI(-) CD48(+) (RMA-S-neo), and MHCI(-) CD48(+) RAE-1γ (RMA-S-RAE-1γ) tumor lines demonstrated that NKG2D activation supersedes the inhibitory effect of both 2B4- and MHCI-mediated immune-tolerance systems. Furthermore, 2B4KO mice subcutaneously challenged with RMA-neo and RMA-S-neo exhibited reduced tumor growth and significantly prolonged survival compared with WT mice, implying that 2B4 is constitutively engaged in the NK-cell tolerance mechanism in vivo. Nevertheless, the inhibitory effect of 2B4 is significantly attenuated when NK cells encountered highly stressed tumor cells expressing RAE-1γ, resulting in an immune response shift toward NK-cell activation and tumor regression. Therefore, our data highlight the importance of the 2B4-mediated inhibitory system as an alternate self-tolerance mechanism, whose role can be modulated by the strength of activating receptor signaling within the tumor microenvironment. This article is protected by copyright. All rights reserved.
    European Journal of Immunology 03/2014; · 4.97 Impact Factor
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    ABSTRACT: An adult passenger has been known to facilitate young drivers' safe driving. This study examined whether the adult passenger's effect is produced by the simple presence of an adult passenger or by the driving tips offered by the passenger. Further, we examined whether the effect would be transferred to when a young driver drives alone without the adult passenger in the following session. Three groups of participants drove on expressway in a driving simulator, either alone, with a silent adult passenger, or with an adult passenger who gave advice on driving safety. After a break, participants in all three conditions drove on the same expressway alone. Results showed that participants who drove with an adult passenger providing driving tips drove more safely than the other groups, and the effect was transferred to even when they drove alone afterwards.
    Accident; analysis and prevention 02/2014; 67C:14-20. · 1.65 Impact Factor
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    ABSTRACT: Object Mannitol, an osmotic agent used to decrease intracranial pressure, can cause acute kidney injury (AKI). The objectives of this study were to assess the impact of mannitol on the incidence and severity of AKI and to identify risk factors and outcome for AKI in patients with intracranial hemorrhage (ICH). Methods The authors retrospectively evaluated 153 adult patients who received mannitol infusion after ICH between January 2005 and December 2009 in the neurosurgical intensive care unit. Multivariate analysis was used to evaluate the risk factors for AKI after ICH. Based on the odds ratio, weighted scores were assigned to predictors of AKI. Results The overall incidence of AKI among study participants was 10.5% (n = 16). Acute kidney injury occurred more frequently in patients who received mannitol infusion at a rate ≥ 1.34 g/kg/day than it did in patients who received mannitol infusion at a rate < 1.34 g/kg/day. A higher mannitol infusion rate was associated with more severe AKI. Independent risk factors for AKI were mannitol infusion rate ≥ 1.34 g/kg/day, age ≥ 70 years, diastolic blood pressure (DBP) ≥ 110 mm Hg, and glomerular filtration rate < 60 ml/min/1.73 m(2). The authors developed a risk model for AKI, wherein patients with a higher risk score showed a graded association with a higher incidence of AKI. Conclusions The incidence of AKI following mannitol infusion in patients with ICH was 10.5%. A higher mannitol infusion rate was associated with more frequent and more severe AKI. Additionally, age ≥ 70 years, DBP ≥ 110 mm Hg, and established renal dysfunction before starting mannitol therapy were associated with development of AKI.
    Journal of Neurosurgery 01/2014; · 3.15 Impact Factor

Publication Stats

2k Citations
732.39 Total Impact Points

Institutions

  • 2014
    • University of Washington Seattle
      Seattle, Washington, United States
  • 2010–2014
    • Sookmyung Women's University
      • Department of Food and Nutrition
      Sŏul, Seoul, South Korea
  • 2009–2014
    • Catholic University of Korea
      • • Department of Neurosurgery
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Hallym University
      Sŏul, Seoul, South Korea
    • Kyungpook National University Hospital
      Sŏul, Seoul, South Korea
  • 2008–2014
    • Yonsei University
      • • College of Nursing
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • National Institutes of Health
      Maryland, United States
  • 2005–2014
    • Sungkyunkwan University
      • • School of Medicine
      • • Samsung Medical Center
      • • Department of Radiation Oncology
      Sŏul, Seoul, South Korea
    • Pohang University of Science and Technology
      • Department of Chemistry
      Antō, North Gyeongsang, South Korea
  • 2004–2014
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2013
    • Joslin Diabetes Center
      • Section on Genetics and Epidemiology
      Boston, MA, United States
    • Seoul National University Hospital
      • Department of Orthopedic Surgery
      Seoul, Seoul, South Korea
    • Kyung Hee University
      • Department of Food and Nutrition
      Seoul, Seoul, South Korea
  • 2012–2013
    • National Institute of Environmental Research
      Sŏul, Seoul, South Korea
    • Korea Institute of Materials Science
      • Division of Materials Processing
      Sŏngnam, Gyeonggi Province, South Korea
    • National Institute of Food and Drug Safety Evaluation
      Sŏul, Seoul, South Korea
    • Asan Medical Center
      • Department of Radiology
      Seoul, Seoul, South Korea
    • Ewha Womans University
      Sŏul, Seoul, South Korea
  • 2011–2013
    • Chung-Ang University
      Sŏul, Seoul, South Korea
  • 2007–2013
    • Harvard Medical School
      • Department of Medicine
      Boston, MA, United States
  • 2006–2013
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
    • University of Ulsan
      • Asan Medical Center
      Urusan, Ulsan, South Korea
  • 2011–2012
    • Gyeongsang National University
      • College of Veterinary Medicine
      Shinshū, South Gyeongsang, South Korea
  • 2006–2012
    • Korea Institute of Science and Technology
      • Sensor System Research Center
      Seoul, Seoul, South Korea
  • 2002–2012
    • Seoul National University
      • • Institute of Health and Environment
      • • School of Public Health
      • • Department of Biological Sciences
      Seoul, Seoul, South Korea
  • 2009–2011
    • Sejong University
      • Faculty of Food Science and Technology
      Sŏul, Seoul, South Korea
  • 2009–2010
    • Brigham and Women's Hospital
      • Department of Medicine
      Boston, Massachusetts, United States
  • 2008–2010
    • Korea University
      • Department of Chemistry
      Seoul, Seoul, South Korea
  • 2001–2010
    • Pusan National University
      • Department of Mechanical Engineering
      Pusan, Busan, South Korea
  • 1999–2009
    • Inha University
      • College of Natural Sciences
      Sŏul, Seoul, South Korea
  • 2006–2007
    • Harvard University
      • Department of Nutrition
      Boston, MA, United States
  • 2004–2005
    • Hongik University
      • Department of Chemical Engineering
      Sŏul, Seoul, South Korea
  • 2003
    • Hong-ik university
      Missouri, United States
  • 1991
    • Yeungnam University
      • Department of Chemistry
      Onyang, South Chungcheong, South Korea