Jung Eun Lee

Brown University, Providence, Rhode Island, United States

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Publications (328)950.57 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The association of egg consumption with subclinical coronary atherosclerosis remains unknown. Our aim was to examine the association between egg consumption and prevalence of coronary artery calcium (CAC). Cross-sectional study of 23,417 asymptomatic adult men and women without a history of cardiovascular disease (CVD) or hypercholesterolemia, who underwent a health screening examination including cardiac computed tomography for CAC scoring and completed a validated food frequency questionnaire at the Kangbuk Samsung Hospital Total Healthcare Centers, South Korea (March 2011-April 2013). The prevalence of detectable CAC (CAC score > 0) was 11.2%. In multivariable-adjusted models, CAC score ratio (95% confidence interval [CI]) comparing participants eating ≥ 7 eggs/wk to those eating < 1 egg/wk was 1.80 (1.14-2.83; P for trend = 0.003). The multivariable CAC score ratio (95% CI) associated with an increase in consumption of 1 egg/day was 1.54 (1.11-2.14). The positive association seemed to be more pronounced among participants with low vegetable intake (P for interaction = 0.02) and those with high BMI (P for interaction = 0.05). The association was attenuated and no longer significant after further adjustment for dietary cholesterol. Egg consumption was associated with an increased prevalence of subclinical coronary atherosclerosis and with a greater degree of coronary calcification in asymptomatic Korean adults, which may be mediated by dietary cholesterol. The association was particularly pronounced among individuals with low vegetable intake and those with high BMI. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    Atherosclerosis 08/2015; 241(2). DOI:10.1016/j.atherosclerosis.2015.05.036 · 3.97 Impact Factor
  • Biomaterials 08/2015; 61:229-238. DOI:10.1016/j.biomaterials.2015.05.040 · 8.31 Impact Factor
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    ABSTRACT: Oxidative stress has been implicated in the pathophysiology of chronic diseases and cigarette smoking is known to be one of the major sources of oxidants. In this study, we investigated whether Korean black raspberry (BR) supplementation could reduce smoke-induced oxidative stress in healthy male smokers. Thirty nine healthy male smokers received either 30 g of freeze-dried BR or placebo for four weeks. Anthropometric and dietary data, smoking history, blood lipid profiles, lipid peroxidation, DNA damage, and antioxidant enzyme activities were assessed at baseline and after supplementation. There was no difference of age, smoking history, anthropometry, and nutrient intake between groups. BR supplementation had no effect on plasma lipid profiles, LDL oxidation, and DNA damage. However, it significantly increased the activity of the antioxidant enzymes, glutathione peroxidase and catalase, and reduced plasma lipid peroxidation. In conclusion, BR supplementation may decrease cigarette smoke-induced oxidative stress through increase of endogenous antioxidant enzyme activities.
    Journal of Functional Foods 06/2015; 16:393-402. DOI:10.1016/j.jff.2015.04.047 · 4.48 Impact Factor
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    ABSTRACT: Controlling bioaerosols has become more important with increasing participation in indoor activities. Treatments using natural-product nanomaterials are a promising technique because of their relatively low toxicity compared to inorganic nanomaterials such as silver nanoparticles or carbon nanotubes. In this study, antimicrobial filters were fabricated from natural Euscaphis japonica nanoparticles, which were produced by nebulizing E. japonica extract. The coated filters were assessed in terms of pressure drop, antimicrobial activity, filtration efficiency, major chemical components, and cytotoxicity. Pressure drop and antimicrobial activity increased as a function of nanoparticle deposition time (590, 855, and 1150 µg/cm2filter at 3-, 6-, and 9-min depositions, respectively). In filter tests, the antimicrobial efficacy was greater against Staphylococcus epidermidis than Micrococcus luteus; ~61, ~73, and ~82% of M. luteus cells were inactivated on filters that had been coated for 3, 6, and 9 min, respectively, while the corresponding values were ~78, ~88, and ~94% with S. epidermidis. Although statistically significant differences in filtration performance were not observed between samples as a function of deposition time, the average filtration efficacy was slightly higher for S. epidermidis aerosols (~97%) than for M. luteus aerosols (~95%). High-performance liquid chromatography (HPLC) and electrospray ionization-tandem mass spectrometry (ESI/MS) analyses confirmed that the major chemical compounds in the E. japonica extract were 1(ß)-O-galloyl pedunculagin, quercetin-3-O-glucuronide, and kaempferol-3-O-glucoside. In vitro cytotoxicity and disk diffusion tests showed that E. japonica nanoparticles were less toxic and exhibited stronger antimicrobial activity toward some bacterial strains than a reference soluble nickel compound, which is classified as a human carcinogen. This study provides valuable information for the development of a bioaerosol control system that is environmental friendly and suitable for use in indoor environments.
    PLoS ONE 05/2015; 10(5):e0126481. DOI:10.1371/journal.pone.0126481 · 3.53 Impact Factor
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    Jung Eun Lee
    05/2015; 82. DOI:10.1016/j.krcp.2015.05.001
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    ABSTRACT: Colorectal cancer is one of the most common causes of cancer morbidity both in men and in women. However, females over 65 years old show higher mortality and lower 5-year survival rate of colorectal cancer compared to their age-matched male counterparts. The objective of this review is to suggest gender-based innovations to improve colorectal cancer outcomes in females. Women have a higher risk of developing right-sided (proximal) colon cancer than men, which is associated with more aggressive form of neoplasia compared to left-sided (distal) colon cancer. Despite differences in tumor location between women and men, most of scientific researchers do not consider sex specificity for study design and interpretation. Also, colorectal cancer screening guidelines do not distinguish females from male, which may explain the higher frequency of more advanced neoplasia when tumors are first detected and false negative results in colonoscopy in females. Moreover, socio-cultural barriers within females are present to delay screening and diagnosis. Few studies, among studies that included both men and women, have reported sex-specific estimates of dietary risk factors which are crucial to establish cancer prevention guidelines despite sex- and gender-associated differences in nutrient metabolism and dietary practices. Furthermore, anti-cancer drug use for colorectal cancer treatment can cause toxicity to the reproductive system, and gender-specific recurrence and survival rates are reported. Therefore, by understanding sex- and gender-related biological and socio-cultural differences in colorectal cancer risk, gender-specific strategies for screening, treatment and prevention protocols can be established to reduce the mortality and improve the quality of life.
    05/2015; 21(17):5167-5175. DOI:10.3748/wjg.v21.i17.5167
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    ABSTRACT: The relation between glycemic index, glycemic load, and subclinical coronary atherosclerosis is unknown. The aim of the study was to evaluate the associations between energy-adjusted glycemic index, glycemic load, and coronary artery calcium (CAC). This study was cross-sectional analysis of 28,429 asymptomatic Korean men and women (mean age 41.4 years) without a history of diabetes or cardiovascular disease. All participants underwent a health screening examination between March 2011 and April 2013, and dietary intake over the preceding year was estimated using a validated food frequency questionnaire. Cardiac computed tomography was used for CAC scoring. The prevalence of detectable CAC (CAC score >0) was 12.4%. In multivariable-adjusted models, the CAC score ratios (95% confidence intervals) comparing the highest to the lowest quintile of glycemic index and glycemic load were 1.74 (1.08 to 2.81; p trend = 0.03) and 3.04 (1.43 to 6.46; p trend = 0.005), respectively. These associations did not differ by clinical subgroups, including the participants at low cardiovascular risk. In conclusion, these findings suggest that high dietary glycemic index and glycemic load were associated with a greater prevalence and degree of CAC, with glycemic load having a stronger association. Copyright © 2015 Elsevier Inc. All rights reserved.
    The American Journal of Cardiology 05/2015; DOI:10.1016/j.amjcard.2015.05.005 · 3.43 Impact Factor
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    ABSTRACT: We set out to investigate the cause of persistently increased signal intensity (SI) in the posterior portion of the proximal patellar tendon (pPT) on T1-weighted images (T1WI). MR imaging was performed in eight cadavers, followed by gross histological examination. In addition, 84 patients without trauma history or anterior knee pain were included to compare the SI of the PTs. The patients were divided according to their age, sex, and Kellgren-Lawrence (KL) grades. The length and thickness of the increased SI portion in the pPT and whole PT (wPT) on T1WI were recorded. Histological specimens demonstrated that the adipose tissue, vessels, and perivascular connective tissue invaginated into the posterior portion of the pPT. This histological anatomy corresponded to the pPT signal change on MR imaging. There was linear and interdigitating increased SI of the pPT in all of the 84 patients (100 %). There were no differences in the lengths and thicknesses of the increased SI portion of pPTs and wPTs according to age, sex, and KL grade (all p > 0.05). The increased SI of the pPT on T1WI and fluid-sensitive MR images results from invaginating fat, vessels, and perivascular connective tissue. It is not pathological, but a normal and common finding. • Increased linear/interdigitated SIs of the pPT is a normal and common finding. • Invaginated adipose tissue, vessels, and connective tissue could contribute to increased SI. • The fibrocartilage has a minimal role in increased SI of the pPT. • Age, sex, and KL grade do not significantly influence the increased SI. • Knowledge of this increased SI should help clinicians to avoid unnecessary treatment.
    European Radiology 04/2015; DOI:10.1007/s00330-015-3722-3 · 4.34 Impact Factor
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    ABSTRACT: Few prospective studies have examined the preventive role of fruit and vegetable intake against cancer in Asian populations. This prospective study evaluated the associations between total fruit intake, total vegetable intake, and total fruit and vegetable intake and total cancer incidence and mortality. This prospective cohort study included 14,198 men 40-59 y of age enrolled in the Seoul Male Cohort Study from 1991 to 1993. Fruit and vegetable intakes were assessed by a validated food-frequency questionnaire. We used Cox proportional hazard regression models to compute RR ratios and 95% CIs. During the follow-up period from 1993 to 2008, 1343 men were diagnosed with cancer, and 507 died of cancer. Total vegetable intake was linearly associated with cancer incidence but was nonlinearly associated with cancer mortality; by comparing ≥500 g/d with <100 g/d of total vegetable intake, the multivariable-adjusted RR for total cancer incidence was 0.72 (95% CI: 0.58, 0.90; P-trend: 0.02; P-nonlinearity: 0.06). For total cancer mortality, the multivariable-adjusted RRs comparing 100 to <200 g/d, 200 to <300 g/d, 300 to <500 g/d, and ≥500 g/d with <100 g/d of total vegetable intake were 0.68 (95% CI: 0.53, 0.88), 0.75 (95% CI: 0.57, 0.98), 0.72 (95% CI: 0.54, 0.95), and 0.67 (95% CI: 0.47, 0.95), respectively (P-trend: 0.09; P-nonlinearity: 0.01). No associations were found between total fruit intake and total cancer incidence and mortality; ≥300 g/d vs. <50 g/d, RR: 1.04 (95% CI: 0.87, 1.25; P-trend = 0.56) for incidence and RR: 0.89 (95% CI: 0.66, 1.21; P-trend = 0.71) for mortality. Our finding suggests that total vegetable intake was linearly associated with cancer incidence but was nonlinearly associated with total cancer mortality. However, total fruit intake was not associated with total cancer incidence and mortality. © 2015 American Society for Nutrition.
    Journal of Nutrition 04/2015; 145(6). DOI:10.3945/jn.114.209437 · 4.23 Impact Factor
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    ABSTRACT: The objective of this study was to examine the factors associated with initiation and continuation of breastfeeding among Korean women in relation to their employment status. Data were collected using a web-based self-administered questionnaire from 1,031 Korean mothers living in Seoul with babies younger than 24 months. Demographic characteristics, education on breastfeeding, rooming in, breastfeeding during hospital stay, and breastfeeding knowledge were examined. Multivariate logistic regression analyses were performed to identify factors associated with initiation and continuation at 1, 6 and 12 months according to mothers' employment status. Breastfeeding initiation rates were similar regardless of mothers' employment status. Continuation rates decreased for both groups of mothers, but were significantly lower among employed mothers at all duration points. Unemployed mothers who were able to keep their babies in the same room during the hospital stay were more likely to initiate breastfeeding. The factor that was consistently associated with breastfeeding continuation for all duration points among unemployed mothers was whether the mother breastfed during the hospital stay. Higher knowledge scores and having an infant with atopic dermatitis were also associated with breastfeeding continuation at 6 months and 12 months, respectively for unemployed mothers, and receiving education on breastfeeding was associated with 12-month continuation for employed mothers. These results emphasize the significant roles of hospitals for breastfeeding initiation and continuation, with rooming-in, initial breastfeeding practice and education during hospital stay as important practices. In addition, for working mothers to continue their breastfeeding, significant support from the workplace is crucial.
    Journal of Korean Academy of Nursing 04/2015; 45(2):306-13. DOI:10.4040/jkan.2015.45.2.306 · 0.36 Impact Factor
  • Jung Eun Lee, Kyung Nam Ryu, Ji Seon Park, Chung Soo Han, Yong Koo Park
    Skeletal Radiology 04/2015; 44(4):577-+. DOI:10.1007/s00256-014-2069-1 · 1.74 Impact Factor
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    ABSTRACT: Introduction Microparticles (MPs) derived from kidney-derived mesenchymal stem cells (KMSCs) have recently been reported to ameliorate rarefaction of peritubular capillaries (PTC) in ischemic kidneys via delivery of proangiogenic effectors. This study aimed to investigate whether KMSC-derived MPs show anti-fibrotic effects by ameliorating endothelial-to-mesenchymal transition (EndoMT) in human umbilical vein endothelial cells (HUVEC) in vitro and by preserving PTC in kidneys with unilateral ureteral obstruction (UUO) in vivo. Methods MPs isolated from the supernatants of KMSC were co-cultured with HUVEC to assess their in vitro biologic effects on endothelial cells. Mice were treated with MPs via the tail vein after UUO injury to assess their anti-fibrotic and PTC sparing effects. Renal tubulointerstitial damage and inflammatory cell infiltration were examined with Masson’s trichrome, F4/80 and α-smooth muscle actin (α-SMA) staining and PTC rarefaction index was determined by CD31 staining. Results KMSC-derived MPs significantly ameliorated EndoMT and improved in vitro proliferation of TGF-β1 treated HUVEC. In vivo administration of KMSC-derived MPs significantly inhibited EndoMT of PTC endothelial cells and improved PTC rarefaction in UUO kidneys. Furthermore, administration of KMSC-derived MPs inhibited inflammatory cell infiltration as well as tubulointerstitial fibrosis in UUO mice as demonstrated by decreased F4/80 and α-SMA-positive cells and Masson’s trichrome staining, respectively. Conclusions Our results suggest that KMSC-derived MPs ameliorate PTC rarefaction via inhibition of EndoMT and protect against progression of renal damage by inhibiting tubulointerstitial fibrosis.
    Stem Cell Research & Therapy 03/2015; 6(1). DOI:10.1186/s13287-015-0012-6 · 4.63 Impact Factor
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    ABSTRACT: Background: The association between coffee intake and type 2 diabetes may be modulated by common genetic variation. Objective: The purpose of this study was to examine the association between habitual coffee intake and the risk of type 2 diabetes and to determine whether this association varies by genetic polymorphisms related to type 2 diabetes in Korean adults. Design and Methods: A population-based cohort study over a follow-up of 4 years was conducted. A total of 4,077 Korean men and women aged 40-69 years with a normal glucose level at baseline were included. Coffee intake was assessed using a validated food frequency questionnaire and incident type 2 diabetes or pre-diabetes was defined by oral glucose tolerance test or fasting blood glucose test. The genomic DNA samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 5.0 and 9 single nucleotide polymorphisms related to type 2 diabetes in East Asian populations were extracted. Results: A total of 120 cases of type 2 diabetes and 1,128 cases of pre-diabetes were identified. After adjustment for potential confounding factors, we observed an inverse association, but without any clear linear trend, between coffee intake and the combined risk of type 2 diabetes and pre-diabetes. We found that inverse associations between habitual coffee intake and the combined risk of type 2 diabetes and pre-diabetes were limited to those with the T-allele (GT/TT) of rs4402960 in IGF2BP2, those with the G-allele (GG/GC) of rs7754840 in CDKAL1, or those with CC of rs5215 in KCNJ11. Conclusion: We found a lower risk of pre-diabetes and type 2 diabetes combined with coffee intake among individuals with the GT/TT of IGF2BP2 rs4402960, GG/GC of CDKAL1 rs7754840, or CC of KCNJ11 rs5215 which are known to be related to type 2 diabetes in East Asians.
    European Journal of Endocrinology 03/2015; 172(5). DOI:10.1530/EJE-14-0805 · 3.69 Impact Factor
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    ABSTRACT: Although various modalities of hemodialysis (HD) are presumed to have different effects on insulin resistance (IR), the relationship between hemodiafiltration (HDF) and IR has not been fully evaluated. In a cross-sectional study, 82 non-diabetic HD patients were enrolled. The patients were divided into two groups according to the median homeostasis model assessment index (HOMA-IR) value of 1.685. Clinical and biochemical data were compared, and multivariate logistic regression analysis was performed to identify the independent factors associated with higher HOMA-IR. The higher HOMA-IR group had increased body mass index (BMI), decreased HDL cholesterol, and lower beta-2 microglobulin reduction rate (β2-MG RR) compared to the lower HOMA-IR group. HOMA-IR was significantly correlated with β2-MG RR. In addition, HDF patients had lower HOMA-IR levels compared with low flux hemodialysis patients. On multivariate logistic regression analysis, BMI and HDF treatment were independent factors associated with higher and lower HOMA-IR, respectively. This study suggests that HDF treatment may reduce IR in non-diabetic HD patients. © 2015 S. Karger AG, Basel.
    Blood Purification 03/2015; 39(1-3):224-229. DOI:10.1159/000368882 · 1.92 Impact Factor
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    ABSTRACT: Previous studies have suggested that solar-induced chlorophyll fluorescence (SIF) is correlated with GPP. However, it remains unclear to what extent this relationship is due to absorbed photosynthetically active radiation (APAR) and/or light use efficiency (LUE). Here we present the first time-series of near-surface measurement of canopy-scale SIF at 760nm in temperate deciduous forests. SIF correlated with GPP estimated with eddy covariance at diurnal and seasonal scales (r2=0.82 and 0.73, respectively), as well as with APAR diurnally and seasonally (r2 = 0.90 and 0.80, respectively). SIF/APAR is significantly positively correlated with LUE and is higher during cloudy days than sunny days. Weekly tower-based SIF agreed with SIF from GOME-2 (The Global Ozone Monitoring Experiment-2, r2 = 0.82). Our results provide ground-based evidence that SIF is directly related to both APAR and LUE and thus GPP, and confirm that satellite SIF can be used as a proxy for GPP.
    03/2015; 42(8). DOI:10.1002/2015GL063201
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    ABSTRACT: Follow-up after primary treatment for breast cancer is an important component of survivor care and various international guidelines exist for the surveillance. However, little is known about current actual practice patterns of physicians whether they adhere to or deviate from recommended guidelines. The aim of this study was to determine how physicians follow-up their patients after primary treatment for breast cancer in Korea. A questionnaire survey with 34 questions in 4 categories was e-mailed to the members of Korean Breast Cancer Society from November to December 2013. Respondents were asked how they use follow-up modalities after primary treatment of breast cancer and we compared the survey results with present guidelines. Of the 129 respondents, 123 (95.3%) were breast surgeons. The most important consideration in follow-up was tumor stage. History taking, physical examinations, and mammography were conducted in similar frequency recommended by other guidelines while breast ultrasonography was performed more often. The advanced imaging studies such as CT, MRI, and bone scan, which had been recommended to be conducted only if necessary, were also examined more frequently. Regular screenings for secondary malignancy were performed in 38 respondents (29.5%). Five years later after primary treatment, almost the whole respondents (94.6%) themselves monitored their patients. A majority of respondents have been performed more intensive follow-up modalities in comparison with present guidelines and less frequently screenings for secondary malignancy. For optimal follow-up of breast cancer survivors, tailored delivery system should be considered.
    03/2015; 88(3):133-9. DOI:10.4174/astr.2015.88.3.133
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    ABSTRACT: To demonstrate and further determine the incidences of repaired supraspinatus tendons on early postoperative magnetic resonance imaging (MRI) findings in clinically improving patients and to evaluate interval changes on follow-up MRIs. Fifty patients, who showed symptomatic and functional improvements after supraspinatus tendon repair surgery and who underwent postoperative MRI twice with a time interval, were included. The first and the second postoperative MRIs were obtained a mean of 4.4 and 11.5 months after surgery, respectively. The signal intensity (SI) patterns of the repaired tendon on T2-weighted images from the first MRI were classified into three types of heterogeneous high SI with fluid-like bright high foci (type I), heterogeneous high SI without fluid-like bright high foci (type II), and heterogeneous or homogeneous low SI (type III). Interval changes in the SI pattern, tendon thickness, and rotator cuff interval thickness between the two postoperative MRIs were evaluated. The SI patterns on the first MRI were type I or II in 45 tendons (90%) and type III in five (10%). SI decreased significantly on the second MRI (p < 0.050). The mean thickness of repaired tendons and rotator cuff intervals also decreased significantly (p < 0.050). Repaired supraspinatus tendons exhibited high SI in 90% of clinically improving patients on MRI performed during the early postsurgical period. The increased SI and thickness of the repaired tendon decreased on the later MRI, suggesting a gradual healing process rather than a retear.
    Korean journal of radiology: official journal of the Korean Radiological Society 03/2015; 16(2):363-71. DOI:10.3348/kjr.2015.16.2.363 · 1.81 Impact Factor
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    ABSTRACT: A microchannel-based aerosol size separator that separates submicron aerosols according to particle inertial differences and Dean vortices in the airflow was developed for use in low-cost, portable, real-time aerosol collectors, detectors, concentrators and other such devices. The microfluidic inertial separator was furthermore applied to simultaneously separate airborne microorganisms by size, such as airborne viruses and bacteria from larger aerosols and viral particles from bacterial cells. The entire system was designed by numerical simulation and analysis. In addition, its performance was evaluated experimentally using airborne standard polystyrene latex (PSL) particles. In addition, two airborne microorganisms, Adenovirus 40 and Staphylococcus epidermidis, were used to verify the performance of the separator. The separation ratios of each bioaerosol were measured using real-time aerosol measurement instruments and quantitative polymerase chain reaction (qPCR) analysis. The system was composed of two 90° curved microchannels and three outlets for separating the virus, bacteria and larger particles, respectively. About 70% of 3-μm particles but almost none of the bioaerosols were separated out at the first outlet. In addition, more than 70% of S. epidermidis and ~70% Adenovirus were separated out at the second and third outlets, respectively. Unwanted particle loss in the system was less than 10%. The results indicated not only good separation of bioaerosols but also the potential of our separator for use in bioaerosol applications.
    Lab on a Chip 02/2015; 15(8). DOI:10.1039/C5LC00079C · 5.75 Impact Factor
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    ABSTRACT: Background: Cough is a distressing symptom in advanced cancer. Opioids are used to relieve respiratory symptoms including dyspnea and cough. In addition to a central mechanism, opioids are thought to work peripherally via opioid receptors of the lung. Therefore, direct inhalation of morphine has been investigated in chronic lung disease or cancer. We report our experience of a nebulized form of morphine to control intractable cough in patients with advanced cancer. Methods and results: Case 1 is a 63-year-old female with terminal lung cancer complaining of a severe dry cough with dyspnea and sleeplessness. Case 2 is a 53-year-old female with thymic carcinoma with multiple lung metastases suffering from severe cough accompanying chest pain and dyspnea. With usual treatment, cough did not improve in these patients. We then administered a nebulized form of morphine: hydrochloro-morphine 5 mg mixed with 3 mL normal saline inhaled by mouth using a nebulizer. When the morphine dose was increased to 10 mg and 15 mg, the patients' cough was relieved to a symptom level of moderate and mild, respectively. Without experiencing any severe systemic side effects of opioids, the patients continued nebulized morphine until death or discharge. Conclusion: Nebulized morphine was effective in controlling intractable cough due to cancer and it was convenient and safe.
    Journal of Palliative Medicine 02/2015; 18(3). DOI:10.1089/jpm.2014.0126 · 2.06 Impact Factor
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    ABSTRACT: To protect patient autonomy when confronting death, the importance of advance directives (ADs) has recently became an issue and gradually accepted in Korea. However, in real practice, ADs were not completed by patients but their families in most cases. To analyze the current situation of performing ADs, we reviewed medical charts of 214 terminal cancer patients admitted to the hospice center from October 2012 to September 2013. Seventy-six (35.5%) patients completed ADs. All ADs were completed by patients themselves. The most common reason for not completing ADs was poor physical and/or mental condition. As a proxy, the majority of patients preferred their spouses (55.3%). Few patients wanted life sustaining treatment (1.3%), however palliative sedation was accepted in 89.5%. The median timing of ADs after admission was three (0-90) days, and duration of survival since ADs was 22 (1-340) days. In conclusion, approximately one third of terminal cancer patients completed ADs by themselves. Considering that patient's poor condition is the main reason for not completing ADs, earlier discussion regarding ADs is necessary to enhance patients' participation.
    Journal of Korean Medical Science 02/2015; 30(2):151-4. DOI:10.3346/jkms.2015.30.2.151 · 1.25 Impact Factor

Publication Stats

3k Citations
950.57 Total Impact Points

Institutions

  • 2015
    • Brown University
      Providence, Rhode Island, United States
  • 2012–2015
    • National Institute of Environmental Research
      Sŏul, Seoul, South Korea
    • Catholic University of Korea
      • • College of Medicine
      • • Department of Neurosurgery
      Sŏul, Seoul, South Korea
    • National Institute of Food and Drug Safety Evaluation
      Sŏul, Seoul, South Korea
    • Ewha Womans University
      Sŏul, Seoul, South Korea
  • 2010–2015
    • Sookmyung Women's University
      • Department of Food and Nutrition
      Sŏul, Seoul, South Korea
    • Kyung Hee University
      • • College of Medicine
      • • Department of Applied Physics
      Sŏul, Seoul, South Korea
    • University of Chicago
      Chicago, Illinois, United States
  • 2014
    • University of Washington Seattle
      Seattle, Washington, United States
    • Gwangju Institute of Science and Technology
      Gwangju, Gwangju, South Korea
    • Konkuk University
      • Department of Chemical Engineering
      Sŏul, Seoul, South Korea
  • 2011–2014
    • Chonbuk National University
      Tsiuentcheou, Jeollabuk-do, South Korea
    • Chung-Ang University
      • College of Pharmacy
      Sŏul, Seoul, South Korea
    • Gyeongsang National University
      • College of Veterinary Medicine
      Shinshū, Gyeongsangnam-do, South Korea
    • Yeungnam University
      • School of Chemical Engineering
      Gyeongsan, Gyeongsangbuk-do, South Korea
  • 2010–2014
    • Seoul National University Hospital
      • • Department of Orthopedic Surgery
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2007–2014
    • Yonsei University
      • • Department of Internal Medicine
      • • College of Medicine
      • • College of Nursing
      Sŏul, Seoul, South Korea
    • Korea University
      • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2005–2014
    • Sungkyunkwan University
      • • School of Pharmacy
      • • School of Medicine
      • • Samsung Medical Center
      • • Department of Radiation Oncology
      Sŏul, Seoul, South Korea
  • 2004–2014
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2001–2014
    • Pusan National University
      • Department of Mechanical Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2013
    • Joslin Diabetes Center
      • Section on Genetics and Epidemiology
      Boston, Massachusetts, United States
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
  • 2012–2013
    • Seoul National University Bundang Hospital
      • • Department of Neurosurgery
      • • Department of Orthopaedic Surgery
      Sŏul, Seoul, South Korea
  • 2007–2013
    • Harvard Medical School
      • Department of Medicine
      Boston, MA, United States
  • 2000–2013
    • Seoul National University
      • • Department of Orthopaedic Surgery
      • • Institute of Health and Environment
      • • Department of Public Health
      • • Department of Biological Sciences
      Sŏul, Seoul, South Korea
  • 2011–2012
    • Chungnam National University
      • Graduate School of Analytical Science and Technology
      Daiden, Daejeon, South Korea
  • 2010–2012
    • Harvard University
      Cambridge, Massachusetts, United States
  • 1999–2012
    • Inha University
      • • Department of Nursing
      • • College of Natural Sciences
      Sŏul, Seoul, South Korea
  • 2009–2011
    • Sejong University
      • Faculty of Food Science and Technology
      Sŏul, Seoul, South Korea
    • National Institutes of Health
      • Division of Clinical and Epidimiological Research
      베서스다, Maryland, United States
    • Samsung Medical Center
      Sŏul, Seoul, South Korea
    • Brigham and Women's Hospital
      Boston, Massachusetts, United States
    • Kyungpook National University Hospital
      Sŏul, Seoul, South Korea
    • Korea Research Institute of Chemical Technology
      Daiden, Daejeon, South Korea
  • 2006–2008
    • University of Ulsan
      • Asan Medical Center
      Urusan, Ulsan, South Korea
    • Inje University
      Kŭmhae, Gyeongsangnam-do, South Korea
  • 2005–2006
    • Korea Institute of Science and Technology
      • Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 2004–2005
    • Hongik University
      • Department of Chemical Engineering
      Sŏul, Seoul, South Korea
  • 2003–2005
    • Pohang University of Science and Technology
      • Department of Chemistry
      Antō, North Gyeongsang, South Korea
    • Hong-ik university
      Missouri, United States