Yong Ju Lee

Konkuk University, Sŏul, Seoul, South Korea

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Publications (29)30.2 Total impact

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    ABSTRACT: A predictive model was performed to describe the growth of Staphylococcus aureus in raw pork by using Integrated Pathogen Modeling Program 2013 and a polynomial model as a secondary predictive model. S. aureus requires approximately 180h to reach 5-6 log CFU/g at 10°C. At 15°C and 25°C, approximately 48 and 20h, respectively, are required to cause food poisoning. Predicted data using the Gompertz model was the most accurate in this study. For lag time (LT) model, bias factor (Bf) and accuracy factor (Af) values were both 1.014, showing that the predictions were within a reliable range. For specific growth rate (SGR) model, Bf and Af were 1.188 and 1.190, respectively. Additionally, both Bf and Af values of the LT and SGR models were close to 1, indicating that IPMP Gompertz model is more adequate for predicting the growth of S. aureus on raw pork than other models. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Meat Science 04/2015; 107:20-25. DOI:10.1016/j.meatsci.2015.04.006 · 2.23 Impact Factor
  • 01/2015; 3(2):105. DOI:10.4168/aard.2015.3.2.105
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    ABSTRACT: Tinnitus is the perception of sound in the absence of any outside acoustic stimulus with high prevalence. Multiple risk factors for tinnitus have been identified. So far, most of studies have concentrated on prevalence and associated chronic disease of tinnitus in adults. In the present study, we focused on tinnitus in adolescents which has not been adequately evaluated. The main goal of this study was to assess the prevalence and associated risk factors of tinnitus in adolescents.
    01/2015; 58(1):12. DOI:10.3342/kjorl-hns.2015.58.1.12
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    ABSTRACT: This study was performed to develop a predictive growth model of Listeria monocytogenes to ensure the safety of raw pork. The pork samples were inoculated with a cocktail of two L. monocytogenes strains ATCC 15313 and L13-2 isolated from pork and were stored at 5, 15, and 25 °C. Results were evaluated using the MicroFit program. To develop primary models, the Baranyi, modified Gompertz, and Logistic model equations were applied to the observed data. The mathematically predicted growth rate parameters were evaluated using the coefficient of determination (R2), bias factor (Bf), accuracy factor (Af), and mean square error (MSE). The Baranyi model, which showed an R2 of 0.998 and MSE of 0.006, was more suitable than the modified Gompertz and Logistic models. In validation study of secondary model, it appeared that MSE's of specific growth rate (SGR) and lag time (LT) were relatively accurate and suitable for modeling the growth of L. monocytogenes. These values indicated that the developed models were acceptable for expressing the growth of microorganisms on raw pork, which can be applied to ensure the safety of meats and to establish standards for avoiding microbial contamination.
    Food Control 10/2014; 44:16–21. DOI:10.1016/j.foodcont.2014.03.024 · 2.82 Impact Factor
  • Journal of Allergy and Clinical Immunology 02/2014; 133(2):AB135. DOI:10.1016/j.jaci.2013.12.499 · 11.25 Impact Factor
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    ABSTRACT: Attention deficit hyperactivity disorder (ADHD) has been associated with impairments in frontal inhibitory function and the catecholaminergic system. ADHD is diagnosed in 3-5% of children. Children with ADHD seem develop various forms of urinary problems such as nocturnal enuresis, dysfunctional voiding, and diurnal incontinence. However, no data exist to confirm the presence of these problems in Korean children with ADHD. We investigated the clinical findings of voiding dysfunction in children with ADHD.
    Journal of the Korean Society of Pediatric Nephrology 01/2014; 18(2):71. DOI:10.3339/jkspn.2014.18.2.71
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    ABSTRACT: Schwannoma arising from cervical sympathetic chain is relatively uncommon and can be occasionally misdiagnosed as carotid body tumor. On MR images, schwannoma shows generally hypointense features on the T1-weighted images and hyperintense features on the T2-weighted images. Occasionally, however, contrast administration, which lets schwannoma show marked enhancement, may make it difficult to differentiate schwannoma from carotid body tumor. A 41-year-old woman presented a neck mass on the left. MR images of the neck and carotid angiography revealed a well-enhancing ovoid tumor, which separated the internal carptod arteries from the external carotid arteries at the level of carotid bifurcation. Complete tumor resection was performed and histopathology findings confirmed a schwannoma originating from the sympathetic chain. Postoperatively, miosis and facial anhydrosis of the left side were noted without ptosis, enophthalmos or other neurologic deficits. We report this case with a review of the literatures.
    01/2014; 57(7):473. DOI:10.3342/kjorl-hns.2014.57.7.473
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    ABSTRACT: Neonatal herpes simplex virus (HSV) encephalitis is a rare disease nowadays because of prenatal screening test and management. It shows progressive central nervous system manifestations affecting predominantly temporal and frontal lobes. Early diagnosis of HSV encephalitis is important since even with the early initiation of high-dose intravenous acyclovir therapy, it results in serious morbidity among survivors. A 14-day-old neonate with fever and poor oral intake was admitted via emergency department. The next day she had seizures and the brain was damaged with permanent sequelae despite of early administration of intravenous acyclovir on day 2 of admission. We report a serious case of HSV encephalitis diagnosed as type 2 HSV by polymerase chain reaction and culture of a newborn without proper prenatal screening test.
    01/2014; 25(3):195. DOI:10.14734/kjp.2014.25.3.195
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    ABSTRACT: Purpose Tinnitus is a very common symptom of vestibular schwannoma, present in 45 to 80% of patients. We evaluated changes in tinnitus after translabyrinthine microsurgery (TLM) or gamma knife radiosurgery (GKS). Materials and Methods Among 78 patients with vestibular schwannoma who underwent TLM or GKS at Severance Hospital from 2009-2012, 46 patients with pre- or postoperative tinnitus who agreed to participate were enrolled. Pure tone audiometry, tinnitus handicap inventory (THI), visual analogue scale (VAS) scores for loudness, awareness, and annoyance were measured before and after treatment. Changes of THI and VAS were analysed and compared according to treatment modality, tumour volume, and preoperative residual hearing. Results In the TLM group (n=27), vestibulocochlear nerves were definitely cut. There was a higher rate of tinnitus improvement in TLM group (52%) than GKS group (16%, p=0.016). The GKS group had a significantly higher rate of tinnitus worsening (74%) than TLM group (11%, p<0.001). Mean scores of THI and VAS scores significantly decreased in the TLM group in contrast to significant increases in the GKS group. Tumor volume and preoperative hearing did not affect the changes in THI or VAS. Conclusion GKS can save vestibulocochlear nerve continuity but may damage the cochlea, cochlear nerve and can cause worsening tinnitus. In cases where hearing preservation is not intended, microsurgery with vestibulocochlear neurectomy during tumor removal can sometimes relieve or prevent tinnitus.
    Yonsei medical journal 01/2014; 55(1):19-24. DOI:10.3349/ymj.2014.55.1.19 · 1.26 Impact Factor
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    ABSTRACT: Varicella zoster virus (VZV) infection of the head and neck region may present with various symptoms. We present a case of VZV infection of the external ear (cranial nerve V), pharynx and larynx with neuropathy of three ipsilateral lower cranial nerves (IX, X, XII). The patient's paresthesia was reduced after antiviral therapy and oral steroids. By the end of one month follow-up, the patient showed normal movement of vocal cord, soft palate and tongue.
    01/2014; 57(11):795. DOI:10.3342/kjorl-hns.2014.57.11.795
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    ABSTRACT: The identification of novel diagnostic markers of pathogenic bacteria is essential for improving the accuracy of diagnoses and for developing targeted vaccines. Streptococcus pneumoniae is a significant human pathogenic bacterium that causes pneumonia. N-acetylglucosamine-6-phosphate deacetylase (NagA) was identified in a protein mixture secreted by S. pneumoniae and its strong immunogenicity was confirmed in an immuno-proteomic assay against the anti-serum of the secreted protein mixture. In this study, recombinant S. pneumoniae NagA protein was expressed and purified to analyze its protein characteristics, immunospecificity, and immunogenicity, thereby facilitating its evaluation as a novel diagnostic marker for S. pneumoniae. Mass spectrometry analysis showed that S. pneumoniae NagA contains four internal disulfide bonds and that it does not undergo post-translational modification. S. pneumoniae NagA antibodies successfully detected NagA from different S. pneumoniae strains, whereas NagA from other pathogenic bacteria species was not detected. In addition, mice infected with S. pneumoniae generated NagA antibodies in an effective manner. These results suggest that NagA has potential as a novel diagnostic marker for S. pneumoniae because of its high immunogenicity and immunospecificity.
    The Journal of Microbiology 10/2013; 51(5):659-64. DOI:10.1007/s12275-013-3451-8 · 1.53 Impact Factor
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    ABSTRACT: Objective: We aimed to evaluate the association between eosinophilic inflammation in induced sputum and pulmonary function and persistent airflow limitation in children. Methods: A total of 92 asthmatic children and 72 controls were enrolled in this study. Eosinophil count (%) and eosinophil cationic protein (ECP) levels were measured in induced sputum. We performed spirometry and a methacholine challenge test and measured total eosinophil count, total serum IgE, and serum ECP in all subjects. Results: Asthmatic children had significantly higher levels of sputum eosinophils (9% vs. 0%; P < 0.001) and sputum ECP (2.3 ± 0.7 vs. 1.6 ± 0.6 log μg/L, P < 0.001) than controls. Sputum ECP levels showed a significant negative correlation with postbronchodilator (postBD) FEV(1) (r = -0.307; P = 0.001) and postBD FEV1/FVC (r = -0.286; P = 0.002), whereas sputum eosinophils showed no correlation with postBD FEV(1) and postBD FEV(1)/FVC. However, no significant differences in sputum ECP and sputum eosinophil counts were observed in asthmatic children with and without persistent airflow limitation. Conclusions: Our findings suggest that sputum eosinophilic inflammation, especially ECP, is associated with pulmonary function and persistent airflow limitation, which is manifested by low postBD FEV(1)/FVC.
    Journal of Asthma 02/2013; 50(4). DOI:10.3109/02770903.2013.776074 · 1.83 Impact Factor
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    ABSTRACT: The aim of the present study was to investigate the protective effects of gomisin A, a lignan compound isolated from Schisandra chinensis, against liver and kidney damage induced by CCl4 exposure. We assessed alterations in organ weights, levels of serum biochemical indicators, and activation of the caspase-3 and MAPK signaling pathways and carried out histological analysis of liver and kidney tissue in rats pretreated with gomisin A for four days. In the gomisin A/CCl4-treated group, only the liver experienced a significant increase in weight, whereas the other organs did not undergo any changes. Five biochemical indicators in serum indicated that liver and kidney toxicity dramatically decreased upon gomisin A pretreatment, although the decrease in ratios varied. Upon histological analysis, the gomisin A/CCl4-treated group showed less hepatocellular necrosis, a poorly dilated central vein in the liver section, decreased diameter of the glomerulus, a lower number of capillaries, and a convoluted tubule in the kidney section. Furthermore, the formation of active caspase-3 was inhibited by gomisin A pretreatment in the gomisin A/CCl4-treated group, whereas the expression level of Bax protein was slightly increased. Western blot analysis revealed that there were differences between the liver and kidney in terms of activation of the MAPK signaling pathway. In the liver, gomisin A pretreatment increased phosphorylation of three members of the MAPK pathway when compared to that in the vehicle pretreatment group. However, in the kidney, only the phosphorylation level of p38 was elevated upon gomisin A pretreatment, whereas levels of the other two members were decreased. These results suggest that gomisin A induces marked protective effects against hepatic and renal injury induced by CCl4 exposure through differential regulation of the MAPK signal transduction pathway.
    International Journal of Molecular Medicine 01/2013; 31(4). DOI:10.3892/ijmm.2013.1263 · 1.88 Impact Factor
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    ABSTRACT: Oral systemic steroids are the most commonly accepted treatment for idiopathic sudden sensorineural hearing loss (SSNHL) despite pathophysiological uncertainty. Recently, intratympanic dexamethasone (ITD) has been proposed as an effective, alternative method for patients in whom oral steroids either fail to respond or are contraindicated. The authors compared the efficacy of ITD according to the duration of hearing loss prior to first dose of ITD.
    01/2013; 56(1):19. DOI:10.3342/kjorl-hns.2013.56.1.19
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    ABSTRACT: Angiomyolipomas (AML) are generally known as benign tumors. The kidney is the most common location of this tumor, and the liver is reported as the second most common site. Occurrence in other tissues is extremely rare. For instance, some cases of AML originating from the nasal cavity have been previously reported. We describe an AML case arising from the nasal cavity of a 56-year-old man. The patient had been complaining of nasal obstruction and foreign body sensation in the nasopharynx and was initially treated with preoperative angio-embolization. AML was then totally removed by endoscopic surgery without complications. He has been asymptomatic and has had no evidence of recurrence for 2 months after surgery.
    01/2013; 56(8):528. DOI:10.3342/kjorl-hns.2013.56.8.528
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    ABSTRACT: The antimicrobial effect of the methanol extract of Inula britannica flowers against methicillin resistant Staphylococcus aureus (MRSA) was investigated. It was confirmed that the methanol extract is mainly composed of quercetin, which has antimicrobial properties. The antimicrobial effect of the methanol extract against 3 MRSA strains was determined by the disc diffusion method. The minimal inhibitory concentrations were ranged from 0.625 mg/ml to 1.25 mg/ml, and the minimum bactericidal concentrations were 2.5 mg/ml. Time kill kinetics revealed bactericidal activities, and the morphological alterations in S. aureus ATCC 33591 treated with the extract were observed using a scanning electron microscope. The methanol extract affected the expression of the resistant genes, mecA, mecI, and mecRI in mRNA. Therefore, the methanol extract of I. britannica flowers clearly demonstrated an antimicrobial effect against MRSA and these results suggest a potential for application as a natural antimicrobial agent.
    Korean Journal of Microbiology and Biotechnology 01/2013; 41(3). DOI:10.4014/kjmb.1305.05005
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    Sang Chul Park · Yong Ju Lee · Jong Gyun Ha · Ja Hyun Lee
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    ABSTRACT: Lemierre syndrome is characterized by a history of recent oropharyngeal infection, clinical or radiological evidence of internal jugular vein thrombosis, and isolation of pathogens, mainly Fusobacterium necrophorum. Septic emboli resulting from infected thrombophlebitis of the internal jugular vein leads to metastatic infections involving lung, liver, kidney, bone and central nervous system. Before the advent of antibiotics, the disease used to be common, incurring a high mortality rate. The disease is less frequently seen nowadays, but it is still a life-threatening disease, requiring a high index of suspicion and prompt treatment. We report a case of Lemierre syndrome, which showed oropharyngeal infection, and internal jugular vein thrombosis.
    01/2013; 56(9):579. DOI:10.3342/kjorl-hns.2013.56.9.579
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    ABSTRACT: Tubular apocrine adenoma (TAA) and syringocystadenoma papilliferum (SCAP) are uncommon cutaneous adnexal neoplasms often found in the head, perianal area, but rarely in external auditory canal (EAC). SCAP in EAC generally presents itself with a mass in the EAC along with conductive hearing loss. We present here a case of a 50-year-old man presenting TAA with SCAP confined to EAC, which was surgically removed. The clinical and histopathological features were described. The patient has been well without relapse or metastasis.
    01/2013; 56(4):229. DOI:10.3342/kjorl-hns.2013.56.4.229
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    ABSTRACT: Background Asthma is a heterogeneous and complex chronic inflammatory disease of the airways. Asthma can be classified as eosinophilic asthma (EA) or noneosinophilic asthma (NEA). We investigated whether children with EA and NEA manifest different clinical characteristics. Methods A total of 158 children with EA and 89 children with NEA were enrolled in this study. We performed pulmonary function and methacholine challenge tests, and measured blood eosinophil count, total serum immunoglobulin E (IgE), serum eosinophil cationic protein (ECP), and sputum cell counts. Results There were no significant differences in age, sex, and body mass index between the EA and NEA groups. The blood eosinophil count and serum ECP were higher in EA than in NEA, whereas the total serum IgE was similar in both groups. Pulmonary function, as measured by forced expiratory volume in 1 second (FEV1), forced expiratory flow at 25 to 75% of forced vital capacity (FEF25–75%), and postbronchodilator (postBD) FEV1 were significantly decreased in children with EA compared to those with NEA. In EA, FEV1, FEF25–75%, and postBD FEV1 correlated negatively with sputum eosinophils. In NEA, FEV1/forced vital capacity (FVC) and FEF25–75% correlated negatively with sputum neutrophils. Sputum eosinophils (in EA) and sputum neutrophils (in NEA) increased with increase in asthma severity. Conclusions The pulmonary function of children with EA is significantly lower than that of children with NEA. In addition, pulmonary function and asthma severity are associated with eosinophilic inflammation in EA and with neutrophilic inflammation in NEA.
    Acta Paediatrica 11/2012; 102(1). DOI:10.1111/apa.12046 · 1.84 Impact Factor
  • Otolaryngology Head and Neck Surgery 08/2012; 147(6). DOI:10.1177/0194599812458876 · 1.72 Impact Factor

Publication Stats

33 Citations
30.20 Total Impact Points

Institutions

  • 2014–2015
    • Konkuk University
      • Department of Food Science and Biotechnology of Animal Resources
      Sŏul, Seoul, South Korea
    • Kangnam University
      이천시, Gyeonggi-do, South Korea
    • Hallym University Medical Center
      Sŏul, Seoul, South Korea
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2012–2014
    • National Health Insurance Corporation Ilsan Hospital
      Sŏul, Seoul, South Korea
    • Hallym University
      • • College of Medicine
      • • Department of Medicine
      Sŏul, Seoul, South Korea
  • 2013
    • Pusan National University
      Tsau-liang-hai, Busan, South Korea
    • Korea Basic Science Institute KBSI
      • Division of Mass Spectrometry Research
      Sŏul, Seoul, South Korea
  • 2011
    • Yonsei University
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
  • 2010–2011
    • Kim's Eye Hospital
      Sŏul, Seoul, South Korea