Qi-Chun Zhang

Nanjing University of Traditional Chinese Medicine, Nan-ching, Jiangsu Sheng, China

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Publications (4)5.32 Total impact

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    ABSTRACT: Objective: To observe the effect of Tongsaimai (TSM) tablets in treating foot trauma of diabetic foot (DF) model rats, and discuss its potential mechanism. Method: Male SD rats were selected to duplicate the diabetic foot ulcer model and randomly divided into the blank control group, the model group, the metformin treatment group, and TSM 12.44, 6.22, 3.11 g x kg(-1) groups (n = 10). The healing of ulcer wounds were observed on day 1, 4, 8, 13 and 18. After 18 days, a histopathologic examination was conducted for ulcer tissues. The contents of superoxide dismutase (SOD) and malondialdehyde (MDA) were detected by hydroxylamine and TBA methods. The content of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were determined with the radioimmunoassay. The immunohistochemical method was used to observe the expression of vascular endothelial growth factor (VEGF) in ulcer tissues and the number of capillary vessels. Result: TSM could alleviate the pathological changes of diabetic foot rats, accelerate the ulcer healing on 4, 8, 13, 18 d, reduce MDA, IL-6, TNF-alpha, VEGF content in rat serum at 18 d (after the rehabilitation period), and enhance the SOD content. Specifically, the TSM 12.44 g x kg(-1) group showed significant differences compared with the model group (P < 0.05, P < 0.01). At 18 d after the treatment (the late rehabilitation period), the VEGF expression of TSM 12.44, 6.22 g x kg(-1) groups and the number of blood capillaries of the TSM 12.44 g x kg(-1) group were significantly lower than that of the model group (P < 0.05, P < 0.01). Conclusion: TSM could promote the foot wound healing of DF model rats, reduce MDA, IL-6 and TNF-alpha levels in serum, increase the SOD content and decrease the VEGF expression and the number of blood capillaries in the late rehabilitation period. Its action mechanism may be related to the inhibition of oxidative stress injury and the inflammatory cell infiltration.
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 06/2014; 39(11):2091-6. DOI:10.4268/cjcmm20141129
  • Qi-Chun Zhang · Yue Zhao · Hui-Min Bian ·
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    ABSTRACT: Our previous investigation had confirmed the inhibition of platelet aggregation of a novel Corni fructus-derived formula composed of malic acid, succinic acid and citric acid with a ratio of 3:2:2. The present study was to further evaluate the anti-thrombotic effect of the formula in vivo. Mice of acute pulmonary thromboembolism, and rats of arterial thrombosis were used to determine the anti-thrombotic effect of the formula. Histology analysis of endothelium was conducted with hematoxylin and eosin stain. TXB2 , 6-K-PGF1α , cAMP, cGMP and NO in rat plasma were determined. In vitro assay of αIIbβ3 and phosphorylation of ERK1/2 were performed in ADP-treated platelet. The formula significantly reduced the recovery time and mortality rate of mice with acute pulmonary thromboembolism. Remarkably extended occlusion time, decreased thrombus weight and more integrated endothelium were observed in rat with the formula. Enhanced 6-K-PGF1α , cGMP and NO, but not TXB2 and cAMP, were demonstrated in rat plasma with treatment of the formula. Finally, the formula was shown to inhibit αIIbβ3 expression and activation of ERK1/2 in platelet. The formula shows positive anti-thrombotic effect. The direct interference on ADP activated signaling in platelet and regulation of endothelium function are two primary pathways involved in the action on thrombosis. Copyright © 2013 John Wiley & Sons, Ltd.
    Phytotherapy Research 05/2014; 28(5). DOI:10.1002/ptr.5052 · 2.66 Impact Factor
  • Qi-Chun Zhang · Yue Zhao · Hui-Min Bian ·
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    ABSTRACT: The present study investigated the antiplatelet activity of a novel formula composed by malic acid, succinic acid and citric acid with a ratio of 3:2:2. The IC50 and inhibition of platelet aggregation induced by various agonists as well as platelet adhesion were evaluated in vitro. Of note, the IC50 for the formula inhibiting adenosine diphosphate (ADP)-induced platelet aggregation was 0.185 mg/mL. Meanwhile, the formula showed more potent inhibitory effect on platelet aggregation induced by ADP and thrombin than the single component at same concentration (0.37 mg/mL). Moreover, the formula could prevent platelet adhesion significantly without influence on platelet viability. Copyright © 2013 John Wiley & Sons, Ltd.
    Phytotherapy Research 12/2013; 27(12). DOI:10.1002/ptr.4934 · 2.66 Impact Factor
  • Yue Zhao · Qi-chun Zhang · Qing Zhu · Shu-mei Yin · Hong-mei Wen · Hui-min Bian ·
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    ABSTRACT: To study the differences between the effects of five Chinese patent medicines on focal cerebral ischemia. Tongsaimai Tablet (TSM), Tongxinluo Capsule (TXL), Buchangnaoxintong (BCNXT), Fufangxueshuantong Capsule (FFXST) and Xuesaitong Capsule. The focal cerebral ischemia rats were modeled by electric coagulation. The water content of brain, cerebral index, cerebral infarction rate, superoxide dismutase (SOD), malondialdehyde (MDA), testosterone (T), estradiol (E2) in serum and expression of estrogen receptor (ER) in brain were detected after adminstration. Compared with the sham group, the water content of brain, cerebral index, cerebral infarction rate the content of MDA and E2 in serum and the ER expression of focal cerebral ischemia rats increased, the activity of SOD and the content of T were decreased. All these five Chinese patent medicines could reduce encephaledema (except TXL) and the infarct range, decrease the content of MDA and the expression of ER. BCNXT and TSM could increase the activify of SOD; FFXST, XST and TSM could increase the content of T; BCNXT, FFXST and XST could decrease the content of E2. The five Chinese patent medicines have the protection effect on cerebral ischemia, but their mechanisms are not exactly the same.
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 06/2011; 34(6):927-31.