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Publications (3)5.1 Total impact

  • S Panhard, I Lozano, G Loussouarn
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    ABSTRACT: Summary Background  While numerous papers have reported on the biological mechanisms of human hair pigmentation and greying, epidemiological descriptions of both natural hair colour and the greying process, worldwide, remain scarce. Objectives  To assess hair colour and greying in a large world sample of human subjects, and to revisit the validity of the 50/50/50 rule of thumb, which states that 'at age 50 years, 50% of the population has at least 50% grey hair'. Methods  The natural hair colour of 4192 healthy male and female volunteers was assessed using a sensorial expert evaluation through the comparison of each volunteer's hair with standard swatches. Hair colour was studied according to age, gender and ethnic or geographical origin. Results  Overall we observed that between 45 and 65 years of age, 74% of people were affected by grey hair with a mean intensity of 27%. Men harboured significantly more grey hair than women. Both age at onset and rate of greying with age appeared to be clearly linked to ethnic/geographical origin. Subjects of Asian and African descent showed less grey hair than those of caucasian origin, at comparable ages, confirming previously reported data. Conclusions  Calculating the percentage of people showing at least 50% grey hair coverage at age 50 years leads to a global range of 6-23%, according to ethnic/geographical origin and natural hair colour: well below that expressed by the '50' rule of thumb.
    British Journal of Dermatology 06/2012; 167(4):865-73. · 3.76 Impact Factor
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    ABSTRACT: Hair pigmentation is one of the most conspicuous phenotypes of humans. From a chemical point of view, however, data remain scarce regarding human hair pigmentation characteristics. To determine melanin content and composition in human eumelanic hair from individuals of different ethnic origins and at different ages, we collected hair from 56 subjects with eumelanic hair from each group of African-American, East Asian, and Caucasian origin. The 56 subjects consist of 14, seven each of males and females, each from four age classes of younger than 11, between 12 and 19, between 20 and 45, and older than 46. We analysed hair colour scale, total melanin value, and contents of pyrrole-2,3,5-tricarboxylic acid (PTCA) and pyrrole-2,3-dicarboxylic acid (PDCA). We measured age-dependent increases in the relative quantity of eumelanin in pigmented human hairs in the three ethnic groups. Regarding melanin composition, we observed an increase in the PDCA/PTCA ratio with age in African-American and Caucasian hairs until approaching the quite constant level of the ratio in East Asian hairs in the elderly individuals. Our results evidence differences in the content and composition of eumelanin in human hair among African-American, Caucasian and East Asian individuals. Furthermore, we show evidence of age-dependent changes in the quantity and quality of eumelanin in pigmented human hairs. In particular, the age-dependent modification of the PDCA/PTCA ratio, a marker for 5,6-dihydroxyindole units in eumelanin, suggests a chronological evolution of hair follicle melanocyte phenotype (e.g. decrease in dopachrome tautomerase expression).
    International journal of cosmetic science 02/2012; 34(1):102-7.
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    ABSTRACT: For many years, cosmetic scientists have attempted to measure the physical features of human hair, such as its shape and colour, as these can be artificially modified using cosmetic products. With regard to hair shape, previous anthropologic studies have emphasized its variability within and between human ethnic groups. Many studies have broadly distinguished three ethnic human subgroups: African, Asian, and Caucasian. Such a broad classification cannot account for the great complexity of human biological diversity, resulting from multiple, past or recent mixed origins. The verbal description of hair shape ranges from the classic to the more sophisticated, with terms such as straight, wavy, curly, frizzy, kinky, woolly, helical, etc. Although these descriptions evoke a global appearance, they remain confusing as their definitions and limits are unclear. Assessments are therefore required to more accurately define such verbal attributes. The work reported here attempts to address the following issues: (i) to define hair types according to specific shape criteria through objective and simple measurements; and (ii) to define such hair types without referring to human ethnicity. Measurements of four parameters related to hair curliness (curve diameter, curl index) or kinking of the hair (numbers of waves, numbers of twists) were performed on hair from 2449 subjects from 22 different countries. Principal components analysis and hierarchical ascendant classification were used to identify homogeneous groups of hair and to determine key variables for the assignment of group membership. Finally, a segmentation tree was prepared in order to establish simple rules for predicting group membership of new subjects. This study has shown that it is possible to classify the various hair types found worldwide into eight main groups. The approach involves objective descriptors of hair shape, and is more reliable than traditional methods relying on categories such as curly, wavy, and kinky. Applied to worldwide human diversity, it avoids reference to the putative, unclear ethnic origin of subjects. Briefly, a straight hair type I is just that, and whether it originates from a Caucasian or an Asian subject is not at issue. The hair types defined here also more adequately reflect the large variation of hair shape diversity around the world, and may possibly help to trace past mixed origins amongst human subgroups.
    International Journal of Dermatology 11/2007; 46 Suppl 1:2-6. · 1.34 Impact Factor