Shijun Liu

Chinese Center For Disease Control And Prevention, Peping, Beijing, China

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Publications (5)10.74 Total impact

  • Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 04/2015; 36(4):409-10.
  • Jian Du · Yuyang Xu · Jun Wang · Shijun Liu · Yan Liu · Xiaoping Zhang · Erping Xu ·
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    ABSTRACT: Objective: To evaluate the impact of the universal infant HepB vaccination program on hepatitis B virus infection in Hangzhou, China. Methods: Hepatitis B incidences and HepB vaccination rates of Hangzhou from 1990 to 2003 were acquired from the historical paper-documents, while which were derived from China Information System for Diseases Control and Prevention and Zhejiang Information System for Immunization Program respectively from 2004 to 2013. A serology survey among person aged 0-59 years was conducted in Hangzhou in 2006. Participants were selected by stratified, multi-stage random sampling. Serum specimens were tested for HBsAg, anti-HBs, anti-HBc, HBeAg and anti-HBe by ELISA. Results: For the past 24 years, hepatitis B incidence and mortality of Hangzhou declined dramatically (χ²=3.2ċ10(4); χ²=172.443; both P for trend< 0.001). Both urban and rural incidence descended (χ² urban=1.904ċ10(4); χ²rural=1.633ċ10(4); both P for trend< 0.001).Hepatitis B patients mainly concentrated in 20-40 years old; workers and farmers were the main infection occupations, which was varies in different years (χ²=1.619ċ10(3), P < 0.001). Significant association was found between incidence of hepatitis B and HepB vaccination rate (r=0.946, χ²=11.813, P for trend=0.001). A total of 5605 participants aged 0-59 years included in this serological survey. The prevalence of HBsAg, anti-HBs, anti-HBc, HBeAg and anti-HBe were 6.19%, 45.83%, 57.25%, 0.62%, and 4.37%, respectively. Conclusions: Hangzhou has successfully integrated the HepB into routine immunization programs and this has had a significant impact on decreasing the incidence of hepatitis B infection.
    Human Vaccines and Immunotherapeutics 02/2015; 11(8). DOI:10.1080/21645515.2015.1008873 · 2.37 Impact Factor
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    ABSTRACT: Objectives: To investigate the coverage of the 23-valent pneumococcal polysaccharide vaccine (23-PPV) in the Chinese urban elderly population and to understand the attitudes, knowledge and beliefs of this population toward the 23-PPV vaccination. Methods: A cross-sectional approach was employed to survey the willingness of this population to receive the 23-PPV vaccination. Two thousand 9 hundred 2 six subjects over the age of 60 y were enrolled via a multi-stage random sampling method from the urban community population in Hangzhou, China. The relationships between the variables and the willingness to receive the 23-PPV vaccination were computed as odds ratios (ORs) by multivariate analysis. Results: Of the participants, 21.77% were willing to undergo 23-PPV vaccination, and 61.65% of the subjects agreed that pneumonia is a serious disease among elderly people. The rate of reasonable perceptions about vaccination, including the perception about vaccine efficacy and safety, among the subjects was below 50%. Only 1.23% of subjects had been vaccinated with 23-PPV, and a similarly low rate was observed for the seasonal influenza vaccine (4.17%). The factors that were independently related to the willingness to receive the 23-PPV vaccine included consensus with the hazards of pneumonia (OR = 1.67, 95% CI: 1.28 - 2.17), the safety of vaccination (OR = 2.00, 95% CI: 1.54 - 2.59), advice about the 23-PPV vaccination from family members (OR = 2.37, 95% CI: 1.39 - 4.40), influenza vaccination history (OR = 2.57, 95% CI: 1.66 - 3.98) and pneumococcal vaccination history (OR = 7.48, 95% CI: 2.4-22.92). Conclusion: The administration of the 23-PPV vaccine among the urban elderly population is not optimistic in China. Emphasis on persuasion from families and the improvement of knowledge about vaccination might encourage elderly people to get the 23-PPV vaccination. Suggestions from physicians did not affect the participants' willingness to get the 23-PPV vaccination in multivariate analysis, but elderly people typically visited the Community Health Center (CHC) in their residential districts, and thus, systematic encouragement from healthcare physicians might be the key to increasing 23-PPV vaccination.
    Human Vaccines and Immunotherapeutics 10/2014; 10(10). DOI:10.4161/21645515.2014.972155 · 2.37 Impact Factor
  • Shijun Liu · Erping Xu · Xioaping Zhang · Yan Liu · Jian Du · Jun Wang · Xinren Che · Wenwen Gu ·
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    ABSTRACT: Objective: Following the national proclaim of Measles Elimination 2012, plenty of activities for controlling the incidence had practiced in Hangzhou. However, the incidence did not decrease to low degree and remained perform as gap to the elimination target. The present study aimed to describe the epidemiological characteristics of measles, and proposed reasonable method to the target in Hangzhou. Method: Cases were collected by the National Notifiable Diseases Surveillance System (NNDSS) from 2004 to 2011. The descriptive epidemiology was employed to analyze characteristics of measles. Results: A total of 4712 confirmed cases were enrolled by the NNDSS with 7.87 per 100,000 people of incidence rate on average from 2004 to 2011. Individuals lived urban districts had higher risk of measles than counties. Infants aged<1 year observed the highest incidence rate with 239.35/100,000, and the age-specific incidence rate declined along with aged-group but reversed at adults. 52.20% of cases were floating cases and the measles vaccination was significantly different from the local cases (χ(2)=51.65, p< 0.001). February to June was the epidemic period for measles incidence with 81.88% of cases reported in cluster. Conclusion: The descriptive characteristics of measles suggested that factors included infant and adult individual, floating population, and living urban area might be relate to the elimination target. More efforts were need to ensure susceptible population had accepted qualified measles vaccination.
    Human Vaccines & Immunotherapeutics 06/2013; 9(6). DOI:10.4161/hv.24032 · 2.37 Impact Factor
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    ABSTRACT: To know the attitude toward seasonal influenza vaccination among healthcare worker (HCWs) and general community population (GCP s) in the post-pandemic influenza A/H1N1 period. A total of 489 participants including 126 HCWs and 363 GCP s completed the investigation. 33.33% individuals (34.92% HCWs vs. 32.78% GCP s, p > 0.05) intended to accept the seasonal influenza vaccination after pandemic influenza A/H1N1. Individuals received seasonal influenza vaccination in the prior 3 y and monovalent A/H1N1 vaccination in 2009 were aggressive to vaccinate seasonal influenza vaccine with adjusted OR = 5.21 (3.20 ~ 8.49) and 1.97 (1.18 ~ 3.30). According to the results of multivariable logistic regression model, the safety not efficacy of influenza vaccine was the significant factor for acceptability of seasonal influenza vaccination (OR: 3.11, 95% CI: 1.76 ~ 5.50). The positive attitude of serious degree of influenza A/H1N1 and occupational factor were also associated with the willingness of seasonal influenza vaccination and the adjusted ORs were 2.09 (1.14 ~ 3.83) and 1.62 (1.00 ~ 2.64). We conducted a cross-sectional investigation in the beginning of seasonal influenza vaccination between 2010 and 2011, employed logistic regression analysis to compute the relationship between the willingness of seasonal influenza vaccination and variables after pandemic influenza A/H1N1. Participants showed low acceptability of seasonal influenza vaccination after pandemic influenza A/ H1N1. Need educational program concerning the advantages of vaccine, comprehensible information about possible adverse effects and the hazards of seasonal influenza disease, which might motivate individuals to accept seasonal influenza vaccination.
    Human vaccines 10/2011; 7(10):1072-6. DOI:10.4161/hv.7.10.16781 · 3.64 Impact Factor

Publication Stats

5 Citations
10.74 Total Impact Points


  • 2015
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
  • 2014
    • Anhui Center for Disease Control and Prevention
      Luchow, Anhui Sheng, China