M Hock

Publications of M Hock

• The early effect of dextran sodium sulfate administration on carbachol-induced short-circuit current in distal and proximal colon during colitis development.

  Authors: M Hock, M Soták, M Kment, J Pácha

  Physiological research / Academia Scientiarum Bohemoslovaca. 12/2011; 60(6):921-31.

  Increased colonic Cl(-) secretion was supposed to be a causative factor of diarrhea in inflammatory bowel diseases. Surprisingly, hyporesponsiveness to Cl(-) secretagogues was later described inIncreased colonic Cl(-) secretion was supposed to be a causative factor of diarrhea in inflammatory bowel diseases. Surprisingly, hyporesponsiveness to Cl(-) secretagogues was later described in inflamed colon. Our aim was to evaluate changes in secretory responses to cholinergic agonist carbachol in distal and proximal colon during colitis development, regarding secretory activity of enteric nervous system (ENS) and prostaglandins. Increased responsiveness to carbachol was observed in both distal and proximal colon after 3 days of 2 % dextran sodium sulfate (DSS) administration. It was measured in the presence of mucosal Ba(2+) to emphasize Cl(-) secretion. The described increase was abolished by combined inhibitory effect of tetrodotoxin (TTX) and indomethacin. Indomethacin also significantly reduced TTX-sensitive current. On the 7th day of colitis development responsiveness to carbachol decreased in distal colon (compared to untreated mice), but did not change in proximal colon. TTX-sensitive current did not change during colitis development, but indomethacin-sensitive current was significantly increased the 7th day. Decreased and deformed current responses to serosal Ba(2+) were observed during colitis induction, but only in proximal colon. We conclude that besides inhibitory effect of DSS on distal colon responsiveness, there is an early stimulatory effect that manifests in both distal and proximal colon.

• [Interindividual differences in priming and memory effects of threatening stimuli: effect of cognitive avoidance and vigilant anxiety coping]

  Authors: M Hock, B Egloff

  Zeitschrift für experimentelle Psychologie : Organ der Deutschen Gesellschaft für Psychologie. 02/1998; 45(2):149-66.

  This study examined the influence of dispositional coping strategies (cognitive avoidance, vigilance) on priming and memory effects of emotional stimuli. In the first phase of the study participantsThis study examined the influence of dispositional coping strategies (cognitive avoidance, vigilance) on priming and memory effects of emotional stimuli. In the first phase of the study participants performed a lexical decision task that involved threat-related and neutral words. Subsequently, a previously unannounced recognition memory test for a subset of the words presented during the first phase was carried out. Repressers (i.e. individuals high in avoidance and low in vigilance) showed stronger emotional priming effects than nonavoiders. Repressers also showed a memory deficit for emotional relative to neutral words, whereas sensitizers (vigilance high, avoidance low) remembered emotional words comparatively well. Results raise the question of whether repressers' memory deficits for threat-related stimuli are actually based on a less differentiated network of emotional information, as assumed by recent theoretical accounts of individual differences in coping.