Raymond N Dubois

Publications (4)64.33 Total impact

• Article: Associations between obesity and cancer: the role of fatty acid synthase.

  Dingzhi Wang, Raymond N Dubois
  CancerSpectrum Knowledge Environment 03/2012; 104(5):343-5. · 14.07 Impact Factor
• Article: Overview of the AACR Clinical and Translational Cancer Research Think Tank meeting.

  Kenneth C Anderson, Raymond N DuBois
  Clinical Cancer Research 02/2012; 18(3):607-11. · 7.74 Impact Factor
• Source

  Available from: PubMed Central

  Article: Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.

  Dianren Xia, Dingzhi Wang, Sun-Hee Kim, Hiroshi Katoh, Raymond N DuBois
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  ABSTRACT: Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression.
  Nature medicine 01/2012; 18(2):224-6. · 27.14 Impact Factor
• Source

  Available from: Jingyu Lang

  Article: APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.

  Qingqing Ding, Chun-Ju Chang, Xiaoming Xie, Weiya Xia, Jer-Yen Yang, Shao-Chun Wang, Yan Wang, Jiahong Xia, Libo Chen, Changchun Cai, [......], Yun-Ju Chen, Chia-Wei Li, Long-Bin Jeng, Jennifer L Hsu, Long-Yuan Li, Alai Tan, Steven A Curley, Lee M Ellis, Raymond N Dubois, Mien-Chie Hung
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  ABSTRACT: Colorectal cancer is the second leading cause of death from cancer in the United States. Metastases in the liver, the most common metastatic site for colorectal cancer, are found in one-third of the patients who die of colorectal cancer. Currently, the genes and molecular mechanisms that are functionally critical in modulating colorectal cancer hepatic metastasis remain unclear. Here, we report our studies using functional selection in an orthotopic mouse model of colorectal cancer to identify a set of genes that play an important role in mediating colorectal cancer liver metastasis. These genes included APOBEC3G, CD133, LIPC, and S100P. Clinically, we found these genes to be highly expressed in a cohort of human hepatic metastasis and their primary colorectal tumors, suggesting that it might be possible to use these genes to predict the likelihood of hepatic metastasis. We have further revealed what we believe to be a novel mechanism in which APOBEC3G promotes colorectal cancer hepatic metastasis through inhibition of miR-29-mediated suppression of MMP2. Together, our data elucidate key factors and mechanisms involved in colorectal cancer liver metastasis, which could be potential targets for diagnosis and treatment.
  The Journal of clinical investigation 11/2011; 121(11):4526-36. · 15.39 Impact Factor