Publications (2)8.39 Total impact
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Article: Macroporous polymer monoliths as second dimension columns in comprehensive two-dimensional gas chromatography: A feasibility study.
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ABSTRACT: When the typical column combinations are used, comprehensive two-dimensional gas chromatography (GC×GC) suffers from the impossibility to operate both dimensions at their optimum carrier gas velocities at the same time. This as a result of the flow mismatch caused by the different dimensions of the columns used. The objective of the present study was the development of monolithic second dimension columns which would allow simultaneous optimum-velocity operation. With monolithic GC columns the optimum performance can be obtained at any given flow rate by varying the bed structure and column diameter. Different divinylbenzene-based monolithic columns were prepared and evaluated in terms of permeability and performance. Plate heights of less than 0.18mm and plate generation rates up to 600 plates/s were achieved. 1D-GC experiments performed on short monolithic columns showed a good resolving power thanks to the elevated retention and the good selectivity. A peak capacity up to 12 peaks per 4-5s was obtained for low-boiling alkanes, confirming the potential for fast separations. Excellent repeatability in terms of retention times (RSD<0.5%) and peak widths (RSD<1.5%) was observed. The columns prepared were successfully used in the second dimension of a GC×GC setup with a standard non-polar first dimension. Model experiments proved the possibility to operate both dimensions at their optimum linear velocity simultaneously. The suitability of the novel second dimension column format to perform multidimensional separations was shown for selected applications.Journal of chromatography. A 10/2012; · 4.19 Impact Factor -
Article: Advancing liquid/liquid extraction through a novel microfluidic device: theory, instrumentation and applications in gas chromatography.
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ABSTRACT: A new chip-based liquid-liquid extraction technique for sample preparation of aqueous samples for GC was developed. Extraction is performed in a segmented flow system with additional mixing provided by an etched channel structure. The dimensions of the device are optimized to allow benefiting of the advantages of chip technology without suffering from the limitations of over-miniaturization. Phase separation is performed with a novel phase separator developed in house. The instrumental set-up is simple. The results obtained for selected test analytes show that the extraction is quantitative (recoveries = 92-110%, RSD < 6%) for a wide range of hydrophobicities (LogK(o/w) = 0.86-4.79). The performance at different flow rates (0.5-6.0 mL/min) and flow ratios (β = 1-10) was evaluated, confirming the flexibility and the possibility to perform enrichment. The results obtained for a few selected applications demonstrate the suitability of the method to perform quick, simple and reliable sample preparation for analytes of interest in real samples.Journal of chromatography. A 08/2011; 1226:77-86. · 4.19 Impact Factor
