ABSTRACT: To describe the characteristics of patients in Hong Kong with or at risk of atherothrombosis, to determine the proportion of symptomatic patients with more than one vascular bed affected, and to assess the relationship between ankle brachial index and disease severity.
Local participation in an international prevalence study.
Five centres in Hong Kong.
A total of 210 subjects were recruited (105 women and 105 men). Patients were divided into the symptomatic group (with current or previous atherothrombotic symptoms, n=101) and at-risk group (with no current or previous symptoms, but aged over 55 years with at least two specified risk factors, n=109).
Patient characteristics were described, including the number of arterial beds affected, ankle brachial index, presence of risk factors, and medications taken.
Of the symptomatic patients, 30% had more than one arterial bed involved. A total of 55.4% of the symptomatic group and 18.4% of the at-risk group had abnormal ankle brachial index values. Lower ankle brachial indices were associated with a greater number of affected arterial beds. Diabetes mellitus and hypertension were the most prevalent risk factors in the at-risk group. Symptomatic patients were commonly treated with antihypertensive and antiplatelet agents, whereas at-risk patients were mostly treated with antihypertensive and antidiabetic agents. Only 20% of at-risk patients were taking antiplatelet agents.
Ankle brachial index is a useful tool for predicting those at risk of atherothrombosis. This simple measurement can be used as part of the screening process in the general practice. The role of antiplatelet agents in primary prevention of atherothrombotic events in at-risk patients deserves further attention.
Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 03/2005; 11(1):36-41.
ABSTRACT: A case-control study with time-related factors was conducted to estimate the latency period of lung cancer. This study included 168 incident male cases of lung cancer histologically confirmed and 336 control patients with non-neoplastic diseases. All patients were interviewed in the hospital wards from May 1987 to May 1990. Data concerning smoking, occupation, method of house heating and cooking fuel used from twelve time windows of looking forward and diet were obtained for three periods of time. A synthetical analysis of forward measures and backward measures were applied. By means of calculating accumulated effective exposure score and excess exposure fraction, the latency period of lung cancer was estimated using multivariate model. Latency of lung cancer is 54.48 years for indoor air pollution, and 56.17 years for total smoking. From estimating latency period of lung cancer from multivariate analysis, it was found that the latency of lung cancer could be affected by the effects of other factors. Therefore, measures which prolong latency period may be of use in the prevention of lung cancer.
Zhonghua zhong liu za zhi [Chinese journal of oncology] 02/1994; 16(1):18-21.
ABSTRACT: A case-control study was carried out in Harbin city to assess the role of diet in the aetiology of colorectal cancer. A total of 336 incident cases of histologically confirmed colorectal cancer (111 colon cancer and 225 rectal cancer) and an equal number of controls with other non-neoplastic diseases were interviewed in hospital wards. Data concerning the average frequency of consumption and amount consumed of single food items were obtained by a dietary history questionnaire. Odds ratios and their confidence limits were computed. Multiple regression for risk status was also used. Vegetables, particularly green vegetables, chives and celery, have a strong protective effect against colorectal cancer. Reduced consumption of meat, eggs, bean products and grain was associated with increasing risk for cancer of the rectum. Alcohol intake was found to be an important risk factor for developing colon cancer and male rectal cancer.
International Journal of Epidemiology 07/1991; 20(2):362-7. · 6.41 Impact Factor