Siobhan Guthrie

Victoria University of Wellington, Wellington, Wellington, New Zealand

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Publications (1)2.92 Total impact

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    ABSTRACT: To investigate the expression of the placental cell-specific associated proteins in infantile haemangioma (IH). Immunohistochemical staining was used to investigate the expression of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), human leucocyte antigen-G (HLA-G), cytokeratin 7 (CK7) and smooth muscle actin in paraffin-embedded sections of proliferating and involuted IHs. The proteins hCG and hPL were expressed by the endothelium but not the pericyte layer of proliferating IH, but these proteins were not detected in involuted lesions. There was no expression of CK7 and HLA-G in IH. The expression of hCG and hPL, but not CK7 or HLA-G, by the endothelium of proliferating IH supports a placental chorionic villous mesenchymal core cellular origin for IH rather than a trophoblast origin.
    Journal of clinical pathology 10/2011; 64(10):870-4. DOI:10.1136/jclinpath-2011-200191 · 2.92 Impact Factor

Publication Stats

17 Citations
2.92 Total Impact Points


  • 2011
    • Victoria University of Wellington
      • School of Biological Sciences
      Wellington, Wellington, New Zealand