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ABSTRACT: In this study we examined right and left ventricular systolic functions in hepatitis B virus (HBV) patients.
The study included 50 HBsAg-positive patients (mean age; 33±13 years) and 50 other persons (mean age; 28±11 years) as a control group. Transthoracic echocardiography was performed in all the participants. Right and left ventricle systolic parameters were compared between these 2 groups.
In the group of the patients with HBsAg positivity, the right ventricular fractional area change (RV FAC), tricuspid annular plane excursion (TAPSE) and RV myocardial systolic velocity (St) values were lower than in the control group (33±11 vs. 52±13%, p=0.001; 14.6±1.1 vs. 22.2±2.4 mm, p<0.001; 8.6±1.2 vs. 15.8±2.3 cm/s, p<0,001, respectively); the right atrium (RA) and RV diameters were higher than in controls (5.1±1.2 vs. 3.7±0.5 cm, p<0.001; 4.9±0.8 vs. 3.4±0.5 cm p<0.001, respectively); and systolic pulmonary artery pressure was higher than in control (39.3±9.5 vs. 22±8.4 mmHg, p<0.001).
The findings showed that HBV infection may be associated with right ventricular systolic dysfunction and pulmonary hypertension.
Medical science monitor: international medical journal of experimental and clinical research 08/2012; 18(9):CR587-91. · 1.70 Impact Factor
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ABSTRACT: Hepatitis secondary to infection with the hepatitis C virus (HCV) is one of the most common causes of viral hepatitis worldwide. Multiple extrahepatic manifestations of HCV infection have been recognized. Dilated and hypertrophic cardiomyopathy associated with HCV infection have been recently described in the literature; however, the effect of HCV infection on the left ventricular systolic and diastolic functions is unknown. Therefore, in this study we aimed to examine left ventricular systolic and diastolic functions in HCV patients.
The study included 50 anti-HCV positive patients and 50 persons for control groups. We performed transthorasic echocardiography and P-wave analysis on all participants. We compared left ventricle diastolic parameters, left ventricle ejection fraction, and P-wave dispersion (Pd) between these two groups. In the group with anti-HCV positivity, the ratio of E/A was found to be lower (1.2 ± 0.7 and 1.37 ± 0.6, P = 0.003); the ratio of E/Em was found to be higher (7.6 ± 1.51 and 6.8 ± 1.72, P = 0.0001). Maximum P-wave duration (Pmax) and Pd were higher in the patient group (99.3 ± 8 and 82.4 ± 7.8, P = 0.004; 44.1 ± 0.9 and 25.3 ± 1.5, P = 0.001). No other statistically significant difference was found between the two groups with regard to the left ventricle systolic and diastolic parameters.
Our findings show that HCV infection may be associated with left ventricular systolic and diastolic dysfunction and cardiac arrhythmias.
Southern medical journal 08/2011; 104(8):543-6. · 0.92 Impact Factor
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ABSTRACT: The aim of this study was to evaluate atrial conduction abnormalities obtained by Doppler tissue imaging (DTI) and electrocardiogram analysis in Atrial septal aneurysm (ASA) patients.
A total of 30 patients with ASA (11 males/19 females, mean age 29.6 ± 11.3 years) and 25 controls (9 males/16 females, mean age 27.6 ± 9.98 years) were included. Interatrial and intraatrial electromechanical coupling (PA) intervals were measured with DTI. P-wave dispersion (Pd) was calculated from the 12-lead electrocardiogram. Systolic and diastolic left ventricular (LV) functions were measured by using conventional echocardiography and DTI.
Atrial electromechanical coupling at the left lateral mitral annulus (PA lateral) was significantly delayed in ASA patients (59.3 ± 4.2 vs. 48.5 ± 1.1 ms, P < 0.0001). Interatrial (PA lateral--PA tricuspid) and intraatrial (PA septum--PA tricuspid) electromechanical coupling interval were significantly longer in ASA patients (26.1 ± 6.2 vs. 14.4 ± 6.75 ms, P < 0.0001 and 9.04 ± 1.1 vs. 5.4 ± 2.5 ms, P < 0.0001). maximum P-wave (Pmax) duration and Pd were significantly longer in ASA patients (98.3 ± 8.1 vs. 86.4 ± 7.8 ms, P < 0.001 and 20.7 ± 0.9 vs. 12.3 ± 1.5, P < 0.0001). Systolic and diastolic left ventricular functions of both groups were comparable.
This study shows that atrial electromechanical coupling intervals and Pd are delayed in ASA patients.
Southern medical journal 06/2011; 104(6):385-8. · 0.92 Impact Factor
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Mehmet Demir
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ABSTRACT: Bicuspid aortic valve is one of the most common congenital heart valve disorders. We present the development of acute myocardial infarction (AMI) in an 18-year-old male patient with unrecognized bicuspid aortic valve and moderate aortic regurgitation. He presented with chest pain. The electrocardiogram showed ST-segment elevation in leads V2 to V6. Creatine kinase-MB level was elevated to 97 U/l and troponin I was very high (45,000 ng/ml). The diagnosis was made as anterior wall AMI. Following treatment with intravenous rt-PA, ST-segment elevation completely returned to normal. Transthoracic echocardiography showed a bicuspid aortic valve, moderate aortic regurgitation, and apical wall hypokinesia; left ventricular global systolic function was normal. The patient had no risk factors for coronary atherosclerosis, nor a history of substance addiction or a family history of coronary artery disease. Protein C, protein S and homocysteine levels were normal. He refused any further intervention. Two weeks after discharge, he presented again with chest pain. Electrocardiography, cardiac markers, and coronary arteriography were normal. He was discharged on appropriate medical treatment. The presented case is the first report of AMI in a patient with bicuspid aortic valve.
Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 10/2009; 37(7):490-2.
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Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 03/2009; 9(1):69-70. · 0.44 Impact Factor
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ABSTRACT: Membranous interventricular septal aneurysm has been reported to accompany atrioventricular (AV) conduction defects. If it is accompanied by AV block, patients generally become symptomatic before the age of 40.
A 65-year-old male presented with presyncope and extreme fatigue for one week. Resting ECG showed a 2: 1 AV block. Transthoracic echocardiography revealed an interventricular septal aneurysm without any shunt. After making the diagnosis of type 2 second-degree AV block, a DDDR pacemaker was implanted.
We presented a 65-year-old male with new-onset presyncope. A diagnosis of septal aneurysm and associated AV block was made and a pacemaker was implanted.
Medical science monitor: international medical journal of experimental and clinical research 02/2006; 12(1):CS1-3. · 1.70 Impact Factor
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ABSTRACT: We designed this study to evaluate the diameters of the aorta and its major branches in patients who had coronary ectasia. We assigned 80 patients (mean age, 57 +/- 11 yr) with isolated coronary artery ectasia to the study group and 25 patients (mean age, 54 +/- 10 yr) without structural or coronary arterial disease to the control group. All patients underwent coronary angiography and angiography of the aorta and its branches. We used computed quantitative angiography to measure the diameters of the coronary arteries, the aorta, and the major aortic branches. Within the study group, the diameter indices of the proximal portions of the right common iliac artery (P=0.041) and the left common iliac artery (P=0.035) were significantly larger than the diameter indices within the control group. The diameter indices of all other evaluated arteries were similar in both groups (all P >0.05).
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 01/2006; 33(4):463-8. · 0.65 Impact Factor
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ABSTRACT: Prosthetic valve thrombosis is a rare and dreaded complication of patients with mechanical valves, particularly those in the mitral position. A 45-year-old female with status post prosthetic mitral valve replacement was admitted to the hospital with acute pulmonary edema. Echocardiography showed mitral valve thrombosis which was treated with tissue plasminogen activator (t-PA). During t-PA infusion she developed acute inferoposterior myocardial infarction. Coronary angiography showed normal coronary arteries. Presented case had acute inferoposterior myocardial infarction secondary to coronary emboli after the successful thrombolytic treatment of prosthetic mitral valve thrombosis.
The International Journal of Cardiovascular Imaging 11/2005; 21(5):509-12. · 2.29 Impact Factor
