Luis Fernández-Vega

University of Oviedo, Oviedo, Asturias, Spain

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Publications (48)125.29 Total impact

  • BMC Medical Genetics 12/2015; 16(1). DOI:10.1186/s12881-015-0221-y · 2.45 Impact Factor
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    ABSTRACT: To elucidate the potential role of single-nucleotide polymorphisms (SNPs) in complement factor H (CFH) gene in Northern Spanish patients with age-related macular degeneration (AMD). A case-control study of 130 unrelated native Northern Spanish diagnosed with AMD (46 dry, 35 neovascular and 49 mixed) and 96 healthy controls matched by age and ethnicity were enrolled. DNA was isolated from peripheral blood and genotyped for AMD-associated SNPs (rs3753394, rs529825, rs800292, rs3766404, rs203674, rs10671170, rs3753396 and rs1065489) using TaqMan probes and restriction fragment length polymorphism (RFLP). The association study was performed using the HaploView 4.0 software. The allelic frequency analysis revealed that rs529825, rs800292, rs203674 and rs10671170 were significantly associated with an increased risk for AMD. The haplotypes CGG (rs3753394, rs529825 and rs800292) and GCAG (rs203674, rs1061170, rs3753396 and rs1065489) were significantly associated with AMD while the haplotypes CAA (rs3753394, rs529825 and rs800292) and TTAG (rs203674, rs1061170, rs3753396 and rs1065489) were found to be protective. Small differ-ences in allelic frequencies were found between dry and neovascular cases; however, these differences were not significant and did not distinguish one form the other. This study found significant association of SNPs rs529825, rs800292, rs203674 and rs1061170 in the CFH gene with susceptibility to AMD. We identified haplotypes that confer protection or increased risk of AMD but not specific genetic variants in CFH capable to distinguish the different clinical forms of AMD in this cohort. Collectively, our results confirmed that CFH represents a strong genetic risk factor for this disease in the Northern Spanish population. © 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
    Acta ophthalmologica 07/2015; DOI:10.1111/aos.12790 · 2.51 Impact Factor
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    ABSTRACT: To evaluate the prevalence of cataract after Implantable Collamer Lens phakic intraocular lens (pIOL) implantation with different models at different ages and for different refractive powers. Fernández-Vega Ophthalmological Institute, Oviedo, Spain. Retrospective nonrandomized clinical study. The pIOL (models V4, V4b, or V4c) was implanted in all cases. The study included 3420 eyes (1898 patients). The mean patient age at surgery was 31.2 years ± 6.4 (SD) (range 18 to 50 years) and the mean spherical refractive error, -7.27 ± 5.24 diopters (D) (range -26.5 to 12.5 D). Twenty-one eyes (0.61%) of 15 patients had pIOL explantation (all model V4) because cataract developed. The mean age of the patients who had explantation was 39.43 ± 4.57 years; 7 were younger than 40 years, and 8 were 40 years or older. The mean spherical equivalent was -10.1 ± 5.41 D; 3 eyes had a pIOL power less than -10.50 D, 4 eyes between -10.50 D and -13.50 D, and 14 higher than -13.50 D. The mean time between pIOL implantation and cataract surgery was 4.2 ± 1.8 years. No eye with implantation of the latest models (V4b and V4c) developed cataract. The mean vault distance in eyes that developed cataracts was 103 ± 69 μm. The incidence of cataract was low after pIOL implantation at the 6-year follow-up. The rate of cataract was higher in older patients and in those with high refractive errors. No author has a financial or proprietary interest in any material or method mentioned. Copyright © 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
    Journal of Cataract and Refractive Surgery 04/2015; 41(4):800-805. DOI:10.1016/j.jcrs.2014.07.039 · 2.55 Impact Factor
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    ABSTRACT: To evaluate the predictability, stability, safety, and efficacy of Visian V4b Implantable Collamer Lens phakic intraocular lens (pIOL) implantation to treat varying degrees of myopia. Fernández-Vega Ophthalmological Institute, Oviedo, Spain. Prospective nonrandomized clinical study. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, pIOL vault, and adverse effects were evaluated 12 months postoperatively. The study enrolled 121 eyes (68 patients). The mean spherical equivalent decreased from -8.61 diopters (D) ± 3.41 (SD) (range -18.75 to -2.25 D) preoperatively to -0.18 ± 0.29 D (range -1.25 to 0.50 D) 12 months postoperatively; 97 eyes (80.2%) were within ±0.25 D of the target refraction and 114 eyes (94.2%) were within ±0.50 D (r(2) = 0.99). The mean Snellen decimal UDVA and CDVA were 0.91 ± 0.17 and 0.97 ± 0.09, respectively. Postoperatively, the UDVA was 20/20 or better in 80 eyes (66.1%) and 20/40 or better in 115 eyes (95.0%). The mean efficacy index was 0.96 ± 0.14. The CDVA was 20/20 or better in 103 eyes (85.1%) and 20/40 or better in all eyes. No eye lost lines of CDVA, and 22 eyes (18.2%) gained 1 or more lines of CDVA. The mean safety index was 1.04 ± 0.10. There were no intraoperative complications. The predictability, safety, and effectiveness of the pIOL were good throughout the 12-month follow-up and comparable to outcomes reported for previous pIOL models. No author has a financial or proprietary interest in any material or method mentioned. Copyright © 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
    Journal of Cataract and Refractive Surgery 01/2015; 41(1):98-104. DOI:10.1016/j.jcrs.2014.05.036 · 2.55 Impact Factor
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    ABSTRACT: To assess visual outcomes after bilateral implantation of an apodized +3.0 diopter (D) addition power toric diffractive multifocal intraocular lens (IOL). Five study sites in Europe and South America. Cohort study. Patients had bilateral implantation of the AcrySof(®) IQ ReSTOR(®)+3.0 D toric multifocal IOL. Inclusion criteria were age from 21 to 70 years, need for bilateral cataract extraction or refractive lens exchange, and regular corneal astigmatism from 0.75 to 2.5 D. Six-month evaluations included spherical equivalent (SE), refractive and corneal cylinder, visual acuity at various distances, defocus testing, reading speed, and IOL rotation. Forty-four of 49 patients completed the 6-month visit. The mean SE (88 eyes) was 0.09 D ± 0.49 (SD) at 6 months (±1.00 D in 95.2%). The mean refractive cylinder decreased from 1.07 ± 0.71 D to 0.33 ± 0.44 D (≤0.50 D in 78.6% and ≤1.00 D in 92.9%). The mean binocular uncorrected visual acuity was 0.04 ± 0.08 logMAR at preferred near (∼39 cm), 0.07 ± 0.09 logMAR at 40 cm, 0.09 ± 0.11 logMAR at 60 cm, and 0.05 ± 0.10 logMAR at 4 m. The mean corrected reading speed increased from 125.43 ± 33.58 words per minute (wpm) to 132.68 ± 23.69 wpm. The mean IOL rotation was 2.20 ± 4.34 degrees. Six months after implantation of the toric multifocal IOL, patients had significantly reduced SE and refractive cylinder, good visual acuity across distances, increased reading speed, and minimal IOL rotation. No author has a financial or proprietary interest in any material or method mentioned.
    Journal of Cataract and Refractive Surgery 01/2014; 40(1):51-9. DOI:10.1016/j.jcrs.2013.06.026 · 2.55 Impact Factor
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    ABSTRACT: Alterations in the sera proteins between patients with Primary Open-Angle Glaucoma (POAG), Pseudoexfoliation Glaucoma (PEXG), and healthy controls were identified through a proven approach utilizing equalization of high-abundance serum proteins with ProteoMiner™, two-dimensional fluorescent difference gel electrophoresis (2D-DIGE), MALDI-TOF/TOF, and nanoLC-MS-MS. Quantitative immunoassays of the 17 most-differentially-altered proteins identified in this analysis confirmed that they were also over expressed in the intact serum of newly recruited glaucoma patients. Overall, this report identifies a panel of candidates for glaucoma biomarkers and supports their further validation in large population studies. Additionally, functional pathway analysis of these candidate proteins suggested that they are part of a network linked to regulating immune and inflammatory-related processes. The data have been deposited to the ProteomeXchange with identifier PXD000198.
    Journal of proteomics 12/2013; 98. DOI:10.1016/j.jprot.2013.12.006 · 3.93 Impact Factor
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    ABSTRACT: To assess subjective outcomes after bilateral implantation of an aspheric apodized diffractive +3.0 diopter (D) multifocal toric intraocular lens (IOL). This was a prospective, single-arm, 6-month study conducted at five study sites in Europe and South America. Forty-nine patients requiring bilateral cataract extraction or refractive lens exchange and IOL implantation in both eyes with preoperative regular corneal astigmatism of 0.75 D or greater and 2.5 D or less received bilateral AcrySof ReSTOR +3.0 D toric IOLs (Models SND1T3, SND1T4, or SND1T5; Alcon Laboratories, Inc., Fort Worth, TX). Subjective questionnaires were administered preoperatively and 6 months postoperatively. Patient subjective experience with visual tasks at all distances improved from the preoperative visit to the 6-month visit. At the 6-month visit, 90% (36 of 40) of respondents reported complete freedom from corrective wear compared with 14% (6 of 43) pre-operatively. On a scale of 0 (worst) to 10 (best), the mean score that patients rated their uncorrected vision was 7.9 ± 1.9 at 6 months (n = 37) compared with 3.6 ± 2.0 at the preoperative visit (n = 38). Six months following bilateral implantation of the AcrySof ReSTOR +3.0 D toric IOL revealed improved subjective experience, increased spectacle freedom, and higher satisfaction when compared with the preoperative baseline. [J Refract Surg. 2013;29(11):762-767.].
    Journal of refractive surgery (Thorofare, N.J.: 1995) 11/2013; 29(11):762-7. DOI:10.3928/1081597X-20131021-06 · 3.47 Impact Factor
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    ABSTRACT: To assess the efficacy, predictability, safety, and stability of the Visian V3 Implantable Collamer Lens posterior chamber phakic intraocular lens (PC pIOL) for moderate to high hyperopia. Private clinic, Oviedo, Spain. Prospective nonrandomized clinical study. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, manifest refraction, endothelial cell density, intraocular pressure (IOP), central vault, and adverse events were evaluated for 3 years postoperatively. The study comprised 73 eyes of 44 patients. The mean spherical equivalent decreased from +4.84 diopters (D) ± 1.6 (SD) (range +1.00 to +7.75 D) preoperatively to -0.13 ± 0.39 D 3 years postoperatively; 61 eyes (83.6%) were within ±0.50 D of the target refraction and all eyes were within ±1.00 D. The mean postoperative Snellen decimal UDVA and CDVA was 0.86 ± 0.17 and 0.91 ± 0.16, respectively. Most eyes (91.8%) had no change from the preoperative CDVA or gained 1 or more lines. One eye (1.4%) lost 2 lines, and no eye lost more than 2 lines. Three years postoperatively, the efficacy index was 1.02 and the safety index was 1.08. The IOP remained stable over time, with no significant increase postoperatively. The mean endothelial cell loss was 4.7%, remaining unchanged over time. No postoperative complications or adverse events, including pupillary block or secondary cataract, occurred. Implantation of the PC pIOL was safe and effective in correcting hyperopic refractive errors, with stable visual and refractive outcomes. No author has a financial or proprietary interest in any material or method mentioned.
    Journal of Cataract and Refractive Surgery 08/2013; 39(10). DOI:10.1016/j.jcrs.2013.04.035 · 2.55 Impact Factor
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    ABSTRACT: PURPOSE: The aim of this work is to evaluate the changes in the central vault after using implantable Collamer® lenses (ICL) to correct myopia. METHODS: This cohort study included 133 eyes; mean spherical equivalent -9.47 ± 3.71 diopters (D) (range: -2.75 to -22.25 D) who underwent ICL V4 implantation. Besides a complete ophthalmologic examination, the central vaulting was measured with Visante OCT and evaluated between different periods of follow-up (1 week, 1, 3, and 6 months, and yearly postoperatively). Post-operative time ranged from 6 to 73 months. RESULTS: Within the first 6 months, the mean central vaulting dropped from 510 ± 238 μm (range 100 to 940 μm) to 439 ± 231 μm (range 90 to 910) a significant decrease by 71 ± 58 μm (range -170 to 30 μm) (p = 0.028) with a trend to a lower reduction after this period. After 36 month from ICL implantation, this variation tends to be smaller with the majority of the eyes having a mean decrease smaller than 2 μm per month. Initial vault (Spearman Rho = -0.237, p = 0.006) was the factor more significantly associated with decrease in vault; eyes presenting a reduction in vault >100 μm had an average initial vault that was 141 μm and 184 μm higher than eyes with no change or with increase in vault over time, respectively. CONCLUSIONS: This study shows a continuous reduction of central vault over time. The reduction is highest during the first 6 months and tends to be lower and slow down over time. The decrease of vaulting was more pronounced in eyes with larger initial vaulting.
    Albrecht von Graæes Archiv für Ophthalmologie 02/2012; 250(12). DOI:10.1007/s00417-012-1957-0 · 2.33 Impact Factor
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    ABSTRACT: To compare visual function after bilateral implantation of the multifocal Lentis Mplus LS-312 with a nonrotational symmetrical design (copolymer aspheric) or the Acrysof Restor SN6AD1 +3.0 D (hybrid aspheric) intraocular lens (IOL). Fernández-Vega Ophthalmological Institute, Oviedo, Spain. Comparative case series. Six months postoperatively, corrected distance visual acuity (CDVA), distance-corrected near visual acuity (DCNVA), the defocus curve, and photopic and mesopic contrast sensitivity with and without glare were measured. The mean CDVA was 0.02 ± 0.06 (SD) with the copolymer aspheric IOL and -0.06 ± 0.05 logMAR with the hybrid aspheric IOL (P=.07) and the mean DCNVA, 0.10 ± 0.06 and -0.09 ± 0.06 logMAR, respectively. The DCNVA was better with the hybrid aspheric IOL (P<.05). The defocus curve showed that the hybrid aspheric IOL provided better visual acuity from 0.00 to -5.00 diopter (D) vergences (P<.05) except for -1.00 and -1.50 D, where the IOLs were comparable. Contrast sensitivity was better with the hybrid aspheric IOL at 12 cycles per degree (cpd) and 18 cpd under photopic conditions (P<.05). No significant differences were found under mesopic conditions (P>.05). Both IOL models gave good and comparable visual acuity at distance. However, the hybrid aspheric IOL provided better DCNVA than the copolymer aspheric IOL. Intermediate vision was not as good as distance and near and was similar between the 2 IOLs. Photopic contrast sensitivity was better with the hybrid aspheric IOL at high spatial frequencies and comparable between IOLs at low frequencies and under mesopic conditions.
    Journal of Cataract and Refractive Surgery 02/2012; 38(2):242-8. DOI:10.1016/j.jcrs.2011.08.034 · 2.55 Impact Factor
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    ABSTRACT: To compare the central postoperative vault of a phakic intraocular lens (pIOL) to correct myopia, myopic astigmatism, and hyperopia and identify ocular and lens parameters that might predict the vault amount. Fernández-Vega Ophthalmological Institute, Oviedo, Spain. Cohort study. Three months after implantation of Implantable Collamer Lens pIOLs to correct myopia, hyperopia, and myopic astigmatism, central vault was measured using optical coherence tomography. Patients were divided into groups according to the preoperative anterior chamber depth (ACD) to compare the effects of ACD, white-to-white (WTW) distance, and lens diameter on postoperative pIOL vault. Hyperopic pIOLs had statistically significantly lower vault followed by myopic pIOLs and toric pIOLs, which had a higher mean value and narrower range (260 to 860 μm). Measured vaults had a positive correlation with preoperative ACD (r = .32, P<.001) and WTW (r = .29, P<.001) and a negative correlation with preoperative spherical equivalent (SE) (r = -0.21, P<.001) and patient age (r = -0.12, P=.025). Eyes with a vault of 250 μm or less had a shallower ACD than eyes with a vault between 250 μm and 750 μm (mean difference -0.11 mm; P=.012) and those with a vault greater than 750 μm (mean difference -0.25 mm; P<.001). Central vaulting was lower in hyperopic eyes. Current nomograms for pIOL diameter selection based on ACD and WTW might yield ideal vault and may have to be adjusted for older patients, shallower ACD, lower WTW, and lower SE.
    Journal of Cataract and Refractive Surgery 01/2012; 38(1):46-53. DOI:10.1016/j.jcrs.2011.07.035 · 2.55 Impact Factor
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    ABSTRACT: To investigate the role of WDR36 and P53 sequence variations in POAG susceptibility. The authors performed a case-control genetic association study in 268 unrelated Spanish patients (POAG1) and 380 control subjects matched for sex, age, and ethnicity. WDR36 sequence variations were screened by either direct DNA sequencing or denaturing high-performance liquid chromatography. P53 polymorphisms p.R72P and c.97-147ins16bp were analyzed by single-nucleotide polymorphism (SNP) genotyping and PCR, respectively. Positive SNP and haplotype associations were reanalyzed in a second sample of 211 patients and in combined cases (n = 479). The authors identified almost 50 WDR36 sequence variations, of which approximately two-thirds were rare and one-third were polymorphisms. Approximately half the variants were novel. Eight patients (2.9%) carried rare mutations that were not identified in the control group (P = 0.001). Six Tag SNPs were expected to be structured in three common haplotypes. Haplotype H2 was consistently associated with the disease (P = 0.0024 in combined cases). According to a dominant model, genotypes containing allele P of the P53 p.R72P SNP slightly increased glaucoma risk. Glaucoma susceptibility associated with different WDR36 genotypes also increased significantly in combination with the P53 RP risk genotype, indicating the existence of a genetic interaction. For instance, the OR of the H2 diplotype estimated for POAG1 and combined cases rose approximately 1.6 times in the two-locus genotype H2/RP. Rare WDR36 variants and the P53 p.R72P polymorphism behaved as moderate glaucoma risk factors in Spanish patients. The authors provide evidence for a genetic interaction between WDR36 and P53 variants in POAG susceptibility, although this finding must be confirmed in other populations.
    Investigative ophthalmology & visual science 09/2011; 52(11):8467-78. DOI:10.1167/iovs.11-7489 · 3.66 Impact Factor
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    ABSTRACT: To evaluate the visual and refractive outcomes of intrastromal corneal ring segment (ICRS) in keratoconic eyes at different stages. Two hundred and nineteen keratoconic eyes were divided into three groups as a function of stage of keratoconus (stages I, II and III). There were 115 eyes with stage I, 84 eyes with stage II and 20 eyes with stage III. Snellen uncorrected distance visual acuity (UDVA), best corrected distance visual acuity (CDVA), and residual refractive errors analyzed using vector analysis were recorded before surgery and 6 months post-surgery. For stage I, UDVA changed from 0.26 ± 0.19 pre-surgery to 0.58 ± 0.30 post-surgery (P < 0.001) and CDVA from 0.79 ± 0.19 to 0.90 ± 0.13 (P < 0.0001). For stage II, UDVA was 0.17 ± 0.15 pre-surgery and 0.35 ± 0.22 post-surgery (P < 0.001) and CDVA changed from 0.56 ± 0.21 to 0.67 ± 0.20 after the surgery (P < 0.0001). For stage III, statistically significant differences both for UDVA and CDVA were not found (P = 0.08 and P = 0.01 respectively). For stage I, 52.16% of the eyes gained lines of CDVA, 39.13% did not change their CDVA, and 8.67% lost lines of CDVA. For stage II, 65.48% of the eyes gained lines of CDVA, 20.24% had unchanged CDVA, and 14.28% lost lines of CDVA. For stage III, 60% of the eyes gained >2 lines of CDVA, 25% did not change their CDVA, and 15% lost lines of CDVA. A significant decrease in the spherical equivalent after surgery was found for stages I and II (P < 0.0001) but not for stage III (P = 0.07). ICRS implantation is an effective procedure for keratoconus treatment, being more effective for moderate keratoconus.
    Albrecht von Graæes Archiv für Ophthalmologie 08/2011; 249(11):1705-12. DOI:10.1007/s00417-011-1759-9 · 2.33 Impact Factor
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    Journal of Cataract and Refractive Surgery 07/2011; 37(7):1374-5. DOI:10.1016/j.jcrs.2011.05.014 · 2.55 Impact Factor
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    ABSTRACT: To evaluate distance, intermediate, and near visual quality in eyes with diffractive intraocular lens (IOL) implantation after previous hyperopic laser in situ keratomileusis (LASIK). Fernández-Vega Ophthalmological Institute, Oviedo, Spain. Cohort study. Corrected distance visual acuity (CDVA) at 12.5%, 25.0%, and 100% contrast levels under photopic and mesopic conditions; uncorrected (UNVA) and distance-corrected (DCNVA) near visual acuity, defocus curves, and corneal higher-order aberrations (HOAs) were measured in eyes that had AcrySof Restor SN60D3 spherical IOL implantation (study group) and in phakic eyes (control group) after hyperopic LASIK. Under photopic conditions at 100% contrast, there were no statistically significant differences between the 2 groups (P > .01) and the CDVA was 0.1 logMAR or better (approximately 20/25) in both groups. At 25.0% and 12.5% contrast, there were no statistically significant differences between the 2 groups (P > .01). Under mesopic conditions, the control group had better CDVA than the study group without glare at all contrasts (P < .01). In the study group, the mean UNVA was 0.017 logMAR ± 0.030 (SD) (approximately 20/20) and the mean DCNVA, 0.009 ± 0.030 logMAR. There was statistically significant worsening of visual acuity as a function of the distance to the test (P < .01). There were no statistically significant differences in HOAs between the 2 groups (P > .01). In eyes with previous hyperopic LASIK, the diffractive IOL provided good visual quality at distance, comparable to that obtained in phakic eyes under photopic conditions, although visual performance was slightly poorer under mesopic conditions. No author has a financial or proprietary interest in any material or method mentioned.
    Journal of Cataract and Refractive Surgery 06/2011; 37(6):1090-6. DOI:10.1016/j.jcrs.2010.11.043 · 2.55 Impact Factor
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    ABSTRACT: To evaluate the long-term safety and efficacy of posterior chamber collagen copolymer phakic intraocular lens (pIOL) implantation to correct myopia. Fernández-Vega Ophthalmological Institute, Oviedo, Spain. Cohort study. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, pIOL vault, endothelial cell loss, and adverse events were evaluated for 5 years after implantation of the Visian Implantable Collamer Lens pIOL for moderate to high myopia. The mean spherical equivalent (188 eyes) decreased from -11.17 diopters (D) ± 3.40 (SD) preoperatively to -0.88 ± 0.72 D 5 years postoperatively. The mean change in refraction from 1 month to 5 years was -0.65 ± 0.65 D. The mean UDVA and CDVA (Snellen decimal) were 0.69 ± 0.26 and 0.83 ± 0.15, respectively. The mean safety and efficacy indices were 1.27 ± 0.33 and 0.89 ± 0.35, respectively. No eye lost more than 2 lines of visual acuity; 70% achieved 0.80 or better CDVA. Three eyes (1.6%) developed late anterior subcapsular cataract that was clinically significant in 1 case, leading to pIOL removal and phacoemulsification. Of the 3 eyes (1.6%) with a mild transient increase in intraocular pressure (up to 27 mm Hg), none required a second surgical procedure or prolonged topical medication. The total endothelial cell loss (considered cumulatively at consecutive intervals through 5 years) was 7.7%. There was a tendency toward decreased pIOL vault decrease over time. No vision-threatening complications occurred. Implantation of the collagen copolymer pIOL for moderate to high myopia was safe and effective and provided long-term predictable, stable refractive results.
    Journal of Cataract and Refractive Surgery 05/2011; 37(5):873-80. DOI:10.1016/j.jcrs.2010.11.040 · 2.55 Impact Factor
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    ABSTRACT: To evaluate the efficacy, safety, and predictability of sequential implantation of Keraring intrastromal corneal ring segments (ICRS) and an Implantable Collamer Lens phakic intraocular lens (pIOL) with corneal relaxing incisions for refractive correction of keratoconus. Fernández-Vega Ophthalmological Institute, Oviedo, Spain. Cohort study. This study comprised patients with keratoconus who had ICRS implantation followed 6 months later by pIOL implantation with corneal relaxing incisions. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities and residual refractive errors, analyzed using vector analysis, were recorded preoperatively, 6 months after ICRS implantation, and 6 months after pIOL implantation. The study enrolled 40 eyes (31 patients). The mean UDVA (decimal) was 0.11 Snellen ± 0.05 (SD) preoperatively, 0.18 ± 0.14 Snellen 6 months after ICRS implantation (P=.001), and 0.50 ± 0.27 Snellen 6 months after pIOL implantation (P<.0001). The mean CDVA was 0.56 ± 0.23 Snellen, 0.68 ± 0.25 Snellen, and 0.73 ± 0.20 Snellen, respectively (all P<.0001). Six months after pIOL implantation, the efficacy index was 0.88 and the safety index, 1.28. At 6 months, 65% of eyes were within ±1.00 diopter (D) of the desired refraction and 45% were within ±0.50 D. The mean spherical equivalent after pIOL implantation was -1.19 ± 1.33 D. Sequential ICRS and pIOL implantation plus corneal relaxing incisions provided good visual and refractive outcomes, indicating that it is a predictable procedure for refractive correction of keratoconus. No author has a financial or proprietary interest in any material or method mentioned.
    Journal of Cataract and Refractive Surgery 04/2011; 37(4):706-13. DOI:10.1016/j.jcrs.2010.10.060 · 2.55 Impact Factor
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    ABSTRACT: To assess efficacy, safety, and predictability after refractive lens exchange (RLE) in patients who had bilateral implantation of an Acri.LISA 366D diffractive bifocal intraocular lens (IOL). Sixty-six eyes of 33 consecutive patients were examined after RLE who had bilateral implantation of an Acri.LISA bifocal 366D IOL. Eyes were divided into myopic and hyperopic groups. Monocular uncorrected distance visual acuity, best-corrected distance visual acuity (BCVA), uncorrected distance near visual acuity, and best distance-corrected near visual acuity (BCNVA) were recorded preoperatively and 6 months after surgery. Efficacy indexes were 0.73 for myopic and 0.85 for hyperopic eyes at 6 months postoperatively. For the myopic group, 2 eyes lost 1 line, 4 eyes gained 1 line, and 6 eyes gained ≥2 lines; for the hyperopic group, 11 eyes lost 1 line, 8 eyes gained 1 line, and 7 eyes gained 2 lines. Safety indexes were 1.07 and 1.03 for myopic and hyperopic eyes, respectively. Safety indexes at near were 1.03 for myopic and 1.00 for hyperopic eyes. Efficacy indexes at near were 1.00 for myopic and 0.99 for hyperopic eyes. Bilateral implantation of an Acri.LISA 366D bifocal IOL after RLE is an effective procedure for correcting ametropia and presbyopia.
    European journal of ophthalmology 03/2011; 21(2):125-31. DOI:10.5301/EJO.2010.2991 · 1.06 Impact Factor
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    ABSTRACT: To assess efficacy, safety, predictability, stability, and patient satisfaction after presbyopic lens exchange in emmetropic patients. A prospective, nonrandomized, masked, observational case series (self-controlled) of 46 emmetropic eyes of 23 consecutive patients (age range: 50 to 60 years) after presbyopic lens exchange with bilateral AcrySof ReSTOR Natural (SN60D3) intraocular lens (IOL) (Alcon Laboratories Inc) implantation were evaluated. Mean spherical equivalent refraction (SE) was -0.04±0.14 diopters (D) (range: +0.25 to -0.25 D). Monocular and binocular uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected near visual acuity (UNVA), distance-corrected near visual acuity (DCNVA), and patient satisfaction were recorded preoperatively and 6 months after surgery. At 6 months postoperative, efficacy index at distance was 1.00. No eye lost ≥2 lines of CDVA, 5 eyes lost 1 line, 24 eyes did not change after surgery, 14 eyes gained 1 line, and 3 eyes gained 2 lines of visual acuity. Safety index at distance was 1.03. All eyes had a manifest SE within ±0.50 D of emmetropia. Mean postoperative SE was +0.14±0.22 D (range: -0.25 to +0.37 D). No eye lost >2 lines of DCNVA, 1 eye lost 2 lines, 3 eyes lost 1 line, 34 eyes did not change after surgery, and 8 eyes gained 1 line of visual acuity. Uncorrected near visual acuity was 0.95±0.07. Safety and efficacy indexes at near were 1.01 and 1.03, respectively. A patient satisfaction questionnaire showed that patients had a high level of satisfaction after presbyopic lens exchange surgery. Presbyopic lens exchange with implantation of the ReSTOR multifocal IOL in emmetropic eyes is an effective and safe procedure for presbyopia correction.
    Journal of refractive surgery (Thorofare, N.J.: 1995) 12/2010; 26(12):927-33. DOI:10.3928/1081597X-20100114-01 · 3.47 Impact Factor
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    ABSTRACT: To evaluate distance contrast sensitivity under photopic, mesopic, and mesopic with glare conditions after implantation of the AcrySof ReSTOR (Alcon Laboratories Inc) and Acri.LISA (Carl Zeiss Meditec) intraocular lenses (IOLs). Binocular contrast sensitivity function was measured with the Optec 6500 FACT contrast sensitivity chart at distance and at three lighting conditions (85 cd/m2 and 3 cd/m2 with and without glare) in 36 eyes of 18 patients implanted with the AcrySof ReSTOR aspheric SN6AD3 IOL and 40 eyes of 20 patients implanted with the Acri.LISA 366D IOL. Results after implantation were compared between lenses at 1 and 6 months. Our results revealed that both IOLs provided good best spectacle-corrected visual acuities at distance and near vision (approximately 20/20), and no statistically significant differences were noted between models at different time points after surgery. Both IOLs provided contrast sensitivity within the normal range in photopic conditions. Under low lighting conditions, a reduction in contrast sensitivity for both lenses, particularly at higher spatial frequencies, was noted. No significant differences were observed between both IOLs at any lighting condition. The AcrySof ReSTOR SN6AD3 and Acri.LISA aspheric IOLs provided contrast sensitivity within normal range under photopic conditions and a reduction in contrast sensitivity under mesopic conditions, with no significant differences between the two brands.
    Journal of refractive surgery (Thorofare, N.J.: 1995) 07/2010; 26(7):471-7. DOI:10.3928/1081597X-20090728-04 · 3.47 Impact Factor

Publication Stats

956 Citations
125.29 Total Impact Points

Institutions

  • 2007–2015
    • University of Oviedo
      • Department of Medicine
      Oviedo, Asturias, Spain
  • 2003–2015
    • Fernández-Vega Ophthalmological Institute
      Madrid, Madrid, Spain