Keisuke Hatano

Publications (2)10.62 Total impact

• Article: Regio- and stereoselective synthesis of 1,4-dienes.

  Shigeki Oishi, Keisuke Hatano, Akira Tsubouchi, Takeshi Takeda
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  ABSTRACT: Titanocene(II)-promoted cross-coupling between (Z)-alkenyl methyl sulfones and terminal allenes produced 1,4-dienes regioselectively via the formation of 2-alkylidenetitanacyclopentanes. Preferential formation of E,Z-dienes was observed in the reaction using aryl-, amino-, and phosphinylallenes.
  Chemical Communications 09/2011; 47(42):11639-40. · 6.17 Impact Factor
• Article: Asymmetric synthesis of (alphaR)-polyfluoroalkylated prolinols based on the perfluoroalkyl-induced highly stereoselective reduction of perfluoroalkyl N-Boc-pyrrolidyl ketones.

  Kazumasa Funabiki, Akitsugu Shibata, Hiroki Iwata, Keisuke Hatano, Yasuhiro Kubota, Kenichi Komura, Masahiro Ebihara, Masaki Matsui
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  ABSTRACT: Reduction of the obtained chiral (S)- tert-butyl 2-(perfluoroalkanoyl)pyrrolidine-1-carboxylate with sodium borohydride or lithium aluminum hydride proceeded smoothly to give the corresponding (S)- tert-butyl 2-((R)-perfluoro-1-hydroxyalkyl)pyrrolidine-1-carboxylate in yields of 73-97% with excellent diastereoselectivities (up to >98% de), compared with the reduction of nonfluorinated (S)-tert-butyl 2-pentanoylpyrrolidine-1-carboxylate.
  The Journal of Organic Chemistry 06/2008; 73(12):4694-7. · 4.45 Impact Factor