Zheyu Chen,
Tianfu Wen,
Yong Zeng,
Lichun Wang, Jia Jie Lu,
Shu Gong,
Hong Tan,
Ping Feng,
Bo Li,
Jichun Zhao,
Wentao Wang,
Mingqing Xu,
Jiayin Yang,
Hong Wu,
Lunan Yan
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ABSTRACT: This study reports our preliminary experience of living donor liver transplantation (LDLT) for patients with acute-on-chronic liver failure (AoCLF) caused by hepatitis B.
47 patients who demonstrated Ao- CLF caused by hepatitis B with mean (±SD) Model for End-Stage Liver Disease scores of 39.2±5.1 were divided by the transplantation group (n=19) and the non-transplantation group (n=28) according to whether or not undergoing LDLT. At the same time, 30 hepatitis B cirrhosis recipients who underwent LDLT and did not reach the criteria of AoCLF were selected as the control group (n=30). In the transplantation group, veno-venous bypass, molecular adsorbent recirculating system (MARS) and continuous renal replacement therapy (CRRT) were introduced. The intraoperative data, post-transplant complications and mortality were analyzed retrospectively.
There were no significant differences in survival rates of 1, 6 and 12 months and the postoperative complications except for pneumonia and diabetes, between the control group and the transplantation group (p>0.05). Recurrence of hepatitis B was not found in the recipients of the control group and the transplantation group.
Right-lobe LDLT may be an effective therapeutic option for patients with acute-on-chronic hepatitis B liver failure.
Hepato-gastroenterology 58(109):1267-73. · 0.66 Impact Factor
