James L Hutchinson

Publications (2)4.65 Total impact

• Article: Anti-inflammatory mediators as physiological and pharmacological regulators of parturition.

  Sara F Rinaldi, James L Hutchinson, Adriano G Rossi, Jane E Norman
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  ABSTRACT: Increasing evidence highlights parturition as an inflammatory event characterized by leukocyte influx and proinflammatory mediator production in the intrauterine environment. While the mechanisms responsible for the initiation of this inflammatory cascade are not well understood, it is clear that these inflammatory events must be tightly regulated as the premature activation of these inflammatory signals is associated with adverse pregnancy outcomes, such as preterm labor, which is the leading cause of neonatal mortality and morbidity. In this article we highlight the importance of anti-inflammatory factors in regulating the inflammatory events surrounding parturition and discuss the use of anti-inflammatory mediators as potential novel therapeutic agents in the treatment of inflammation-induced preterm labor.
  Expert Review of Clinical Immunology 09/2011; 7(5):675-96. · 2.07 Impact Factor
• Article: Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system.

  James L Hutchinson, Shalini P Rajagopal, Kurt J Sales, Henry N Jabbour
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  ABSTRACT: Inflammatory processes are central to reproductive events including ovulation, menstruation, implantation and labour, while inflammatory dysregulation is a feature of numerous reproductive pathologies. In recent years, there has been much research into the endogenous mechanisms by which inflammatory reactions are terminated and tissue homoeostasis is restored, a process termed resolution. The identification and characterisation of naturally occurring pro-resolution mediators including lipoxins and annexin A1 has prompted a shift in the field of anti-inflammation whereby resolution is now observed as an active process, triggered as part of a normal inflammatory response. This review will address the process of resolution, discuss available evidence for expression of pro-resolution factors in the reproductive tract and explore possible roles for resolution in physiological reproductive processes and associated pathologies.
  Reproduction 04/2011; 142(1):15-28. · 2.58 Impact Factor