Ilya Gorbachinsky

Wake Forest University, Winston-Salem, North Carolina, United States

Are you Ilya Gorbachinsky?

Claim your profile

Publications (8)13.35 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Vulvovaginitis has a known association with urinary tract infections (UTIs) in girls. We hypothesize that vulvovaginitis is a major contributor to UTIs in prepubertal girls by increasing periurethral colonization with uropathogens. Periurethral swabs and urine specimens were obtained from a total of 101 girls (58 with vulvovaginitis and 43 without vulvovaginitis). Specimens were cultured for bacterial growth. The dominant organism in the periurethral swabs and urine cultures was recorded and antibiotic sensitivity profiles were compared. Periurethral swabs from children with vulvovaginitis were associated with a statistically significant increase in uropathogenic bacteria (79% Enterococcus species or Escherichia coli) as the dominant culture compared with swabs from girls without vaginitis (18%) (p < 0.05). In children with vulvovaginitis, 52% of the urine cultures were positive for UTIs, and the dominant organism in the urine cultures matched the species and antibiotic sensitivity profile of the corresponding periurethral swab. Only 11% of the urine cultures from girls without vulvovaginitis were positive for UTIs. Vulvovaginitis may cause UTIs by altering the perineal biome such that there is increased colonization of uropathogens.
    Therapeutic Advances in Urology 12/2014; 6(6):224-229. DOI:10.1177/1756287214542097
  • The Journal of Urology 04/2014; 191(4):e869. DOI:10.1016/j.juro.2014.02.2364 · 3.75 Impact Factor
  • Kyle D Wood, Ilya Gorbachinsky, Jorge Gutierrez
    [Show abstract] [Hide abstract]
    ABSTRACT: The objective of this review article is to present the current literature on medical expulsive therapy (MET) and help guide practitioners in the appropriate use of MET for treatment of stone disease. Kidney stones can be treated with multiple modalities including medical therapy, ureteroscopy, shock wave lithotripsy (SWL), percutaneous nephrostolithotomy, open/laparoscopic stone removal, and/or combinations of these modalities. The choice of intervention depends on patient factors, anatomical considerations, surgeon preference, and stone location and characteristics. MET is an excellent treatment modality in the appropriately selected patient. The AUA/EAU guidelines suggest MET as a reasonable treatment choice in select patients. A review of the data suggests the use of alpha antagonist and calcium channel blockers can improve stone expulsion rates. Most data suggests alpha antagonists as superior to calcium channel blockers. There are numerous available alpha antagonists, all of which have supporting data for their use in MET. Evidence suggests that MET can decrease colic events, narcotic use, and hospital visits. MET may also reduce medical costs and prevent unnecessary surgeries and the associated risks. Further, there is a role for alpha antagonists and calcium channel blockers in improving stone passage and decreasing pain in those subjects treated with other modalities (i.e. SWL and ureteroscopy). Despite this evidence, MET remains underutilized as a treatment modality.
    Indian Journal of Urology 01/2014; 30(1):60-4. DOI:10.4103/0970-1591.124209
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To determine whether age of toilet training is associated with dysfunctional voiding in children.
    01/2014; 6:127-30. DOI:10.2147/RRU.S66839
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Background / Purpose: Post-therapy bladder neck contractures can be a challenge to treat. Some reports of transurethral injection of scars with various agents have shown promise. We compare use of intralesional injection with mitomycin C and tacrolimus combined with TUIBN in a 10-patient cohort. Main conclusion: At a median of 7.5 months follow up, it seems that intralesional injection combined with transurethral incision can provide potency.
    Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction 2013 Winter meeting; 03/2013
  • The Journal of Urology 04/2011; 185(4). DOI:10.1016/j.juro.2011.02.1383 · 3.75 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Urethral strictures are from periurethral spongiofibrosis that develops as a result of urethral trauma, disease, or iatrogenic injury. The spongy tissue that surrounds the strictured urethra has an altered ratio of collagen, with increased collagen type I relative to type III. We evaluated the ability of a urethral catheter that was coated with halofuginone (HF), a potent type I collagen inhibitor, to prevent spongiofibrosis formation in a rat model. HF was coated on silicone catheters and release kinetics were measured. Success of impregnation was evaluated with scanning electron microscopy, serial weights, and drug elution data. Urethral strictures were induced in rats using electrocautery. Half the animals had placement of an HF-coated catheter while the others had uncoated silicone controls. Animals were sacrificed at predetermined time points, and urethral tissue was either processed for staining with Masson trichrome and anti-alpha-1 collagen or digested to determine HF concentration. Serum drug levels were also determined in treated animals. Slides were graded by a pathologist who was blinded to treatment to determine collagen deposition. HF was coated successfully on silicone catheters. Local urethral concentration of HF was tenfold higher than serum concentration in treated rats. Animals with HF-coated catheters had no new type I collagen deposition after urethral injury. Control animals had increased periurethral collagen type I deposition, typical of urethral stricture formation. HF can be coated successfully on silicone catheters. HF successfully inhibits periurethral type I collagen deposition after urethral injury. This may become an important therapy to prevent urethral stricture formation or recurrence after endoscopic therapy.
    Journal of endourology / Endourological Society 01/2011; 25(1):107-12. DOI:10.1089/end.2010.0514 · 2.10 Impact Factor
  • Source
    Ilya Gorbachinsky, Haluk Akpinar, Dean G Assimos
    [Show abstract] [Hide abstract]
    ABSTRACT: Metabolic syndrome (MetS) is a complex entity consisting of multiple interrelated factors including insulin resistance, central adiposity, dyslipidemia, endothelial dysfunction and atherosclerotic disease, low-grade inflammation, and in males, low testosterone levels. MetS has been linked to a number of urologic diseases including nephrolithiasis, benign prostatic hyperplasia and lower urinary tract symptoms, erectile dysfunction, male infertility, female incontinence, and prostate cancer. This article reviews the relationships between MetS and these entities. Urologists need to be cognizant of the impact that MetS has on urologic diseases as well as on overall patient health.
    Reviews in urology 01/2010; 12(4):e157-80.