Huiliang Feng

Publications (3)17.71 Total impact

• Article: Ruthenium-Catalyzed Oxidative Coupling/Cyclization of Isoquinolones with Alkynes through CH/NH Activation: Mechanism Study and Synthesis of Dibenzo[a,g]quinolizin-8-one Derivatives.

  Bin Li, Huiliang Feng, Nuancheng Wang, Jianfeng Ma, Haibin Song, Shansheng Xu, Baiquan Wang
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  ABSTRACT: The mechanism of [{RuCl(2) (p-cymene)}(2) ]-catalyzed oxidative annulations of isoquinolones with alkynes was investigated in detail. The first step is an acetate-assisted CH bond activation process to form cyclometalated compounds. Subsequent mono-alkyne insertion of the RuC bonds of the cyclometalated compounds then takes place. Finally, oxidative coupling of the CN bond of the insertion compounds occurs to afford Ru(0) sandwich complexes that undergo oxidation to regenerate the catalytically active Ru(II) complex with the copper oxidant and release the desired dibenzo[a,g]quinolizin-8-one derivatives. All of the relevant intermediates were fully characterized and determined by single crystal X-ray diffraction analysis. The [{RuCl(2) (p-cymene)}(2) ]-catalyzed CH bond functionalization of isoquinolones with alkynes to synthesize dibenzo[a,g]quinolizin-8-one derivatives through CH/NH activation was also demonstrated.
  Chemistry 08/2012; 18(40):12873-9. · 5.93 Impact Factor
• Article: Ruthenium-catalyzed oxidative C-H bond olefination of N-methoxybenzamides using an oxidizing directing group.

  Bin Li, Jianfeng Ma, Nuancheng Wang, Huiliang Feng, Shansheng Xu, Baiquan Wang
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  ABSTRACT: Ruthenium-catalyzed oxidative C-H bond olefination of N-methoxybenzamides using an oxidizing directing group with a broad substrate scope is reported. The reactions of N-methoxybenzamides with acrylates in MeOH and styrene (or norbornadiene) in CF(3)CH(2)OH afforded two types of products.
  Organic Letters 02/2012; 14(3):736-9. · 5.86 Impact Factor
• Article: Ruthenium-catalyzed isoquinolone synthesis through C-H activation using an oxidizing directing group.

  Bin Li, Huiliang Feng, Shansheng Xu, Baiquan Wang
  Chemistry 09/2011; 17(45):12573-7. · 5.93 Impact Factor