Fabio Leva

Publications (2)1.83 Total impact

• Source

  Available from: Daniele Porru

  Article: Explorative study on the use of omalizumab in patients suffering from interstitial cystitis/bladder pain syndrome

  Daniele Porru, Enrica Bucchioni, Marcello Macchi, Fabio Leva, Alberto Parmigiani, Davide Barletta, Dimitrios Choussos, Barbara Gardella, Maria Diletta, Daccò, Elena Nappi, Massimo Allegri, Carlo Maria, Bianchi, Arsenio Spinillo, Bruno Rovereto
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  ABSTRACT: The aim of this study was to evaluate the efficacy of omalizumab in the treatment of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS), evaluated by visual analogue score for pain and urgency-frequency, O'Leary-Sant IC symptom and problem index questionnaire, Pain Urgency Frequency questionnaire and Patient Global Assessment questionnaire. Four female patients with a diagnosis of IC/BPS were included in the study, with an age between 20 and 39 years. In the first patient the subjective final evaluation was of a marked improvement. The second patient had a mod-erate improvement of the subjective final eval-uation. The third patient considered her over-all clinical situation to have slightly improved after treatment. One 32-year-old patient, with multiple allergies, discontinued treatment after 3 months and could not complete the study due to side effects. Omalizumab was subcutaneously administered to patients with IC/PBS; it induced both a subjective and objec-tive improvement of symptoms in 2 patients enrolled in the study.
  Urogynaecologia International Journal 08/2012; 26(8):22-25.
• Article: Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis.

  Daniele Porru, Fabio Leva, Alberto Parmigiani, Davide Barletta, Dimitrios Choussos, Barbara Gardella, Maria Diletta Daccò, Rossella Elena Nappi, Massimo Allegri, Carmine Tinelli, Carlo Maria Bianchi, Arsenio Spinillo, Bruno Rovereto
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  ABSTRACT: Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months. The score for urgency was reduced from 6.5 to 3.6 (p = 0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p = 0.0001). The average urine volume increased from 129.7 to 162 ml (p < 0.0001), with a reduction in the number of voids in 24 h, from 14 to 11.6 (p < 0.0001). The IC Symptom and Problem Index decreased from 25.7 to 20.3 (p < 0.0001), and the Pain Urgency Frequency score, from 18.7 to 12.8 (p < 0.0001). The treatment appeared to be effective and well tolerated in IC/BPS in this initial experience.
  International Urogynecology Journal 09/2011; 23(9):1193-9. · 1.83 Impact Factor