Yanhong Li

Publications (2)3.87 Total impact

• Article: The Value of Aneurysm Volume and Myocardial Strain Rate for Evaluating Cardiac Function of Ischemia-Related Left Ventricular Aneurysm in a Rabbit Model Using Real Time Three-Dimensional Echocardiographic Imaging Combined with Speckle Tracking Imaging.

  Hong Zhai, Yuming Mu, Lina Guan, Yanhong Li
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  ABSTRACT: PURPOSE: The aim of this study was to evaluate the effect of left ventricular aneurysm (LVA) volume and myocardial strain on left ventricular function in a rabbit model using real time three-dimensional echocardiographic imaging (RT-3DE) combined with two-dimensional speckle tracking imaging (2D-STI). METHODS: A rabbit model of LVA was prepared in 30 New Zealand rabbits by ligating the middle segment of the left anterior descending artery and the left circumflex artery (LVA group); 10 control rabbits underwent thoracotomy alone. Four weeks later, RT-3DE was performed to obtain data on left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), and LVA volume. The peak short-axis radial (SrR) and circumferential (SrC) strain rates were measured using 2D-STI technique. RESULTS: Compared with control rabbits, LVA group rabbits had significant left ventricular enlargement at the end-systolic and end-diastolic phases (both P < 0.05). LVEF, SrR-Systolic, and SrC-Systolic were significantly lower in the LVA group (all P < 0.05). Moreover, there were high correlations between LVEF and SrC-Systolic(anterior wall) , SrR-Systolic(anterior wall) , SrC-Systolic(lateral wall) , and SrR-Systolic(lateral wall) (r = -0.895, -0.887, -0.890, -0.891, respectively, all P < 0.05). Of note, LVA volume/LVEDV had the tightest inverse relationship with LVEF (r = -0.911, P < 0.01). Specifically, LVA volume/LVEDV >16% corresponded to LVEF <50%, and LVEF decreased 1.1% while LVA volume/LVEDV increased 1%. CONCLUSIONS: LVA volume/LVEDV provided a sensitive indicator reflecting cardiac function with LVA. Measurement of various parameters using RT-3DE might be a useful means to evaluate cardiac function after LVA formation.
  Echocardiography 02/2013; · 1.24 Impact Factor
• Article: Transplantation of induced bone marrow mesenchymal stem cells improves the cardiac function of rabbits with dilated cardiomyopathy via upregulation of vascular endothelial growth factor and its receptors.

  Yuming Mu, Guiqiu Cao, Qianqian Zeng, Yanhong Li
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  ABSTRACT: Bone marrow mesenchymal stem cells (BMMSCs) have shown promise in repairing injured myocardium. However, few studies have explored the potential of BMMSC transplantation for dilated cardiomyopathy (DCM). In this study we aimed to examine whether BMMSC transplantation improves the cardiac function of dilated cardiomyopathy and investigate the underlying mechanism. We established a DCM model in rabbit, then transplanted BMMSCs induced by 5-azacytidine into the rabbit, and determined the left ventricular pressure and the expression of vascular endothelial growth factor (VEGF) and its receptors. Immunohistochemistry, ultrastructural and reverse transcription polymerase chain reaction (RT-PCR) analysis proved that 5-azacytidine induced the differentiation of BMMSCs into cardiomyocyte-like cells. Upon transplantation of the induced BMMSCs into a DCM model, significantly higher maximum rates of rise and decline (±dp/dt) of left ventricular pressure and left ventricular systolic pressure, as well as much lower left ventricular diastolic pressure, were observed compared with the control group (P < 0.05). After four weeks, deposition of collagen fibers in the myocardium of transplantation group was reduced, accompanied by increased expression of VEGF and its receptors as detected by RT-PCR. Taken together, our results suggest that BMMSC transplantation could alleviate DCM through angiogenesis via the upregulation of VEGF and its receptors.
  Experimental Biology and Medicine 07/2011; 236(9):1100-7. · 2.64 Impact Factor