Xiaomei Zhou

Publications (2)2.21 Total impact

• Article: Differences in heart stroke volume between Han and Korean-Chinese nationalities and correlative factors.

  Yangxing Pan, Baoshen Qi, Xiaomei Zhou, Shaomei Han, Xue Zhang, Zhengguo Zhang, Guangjin Zhu
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  ABSTRACT: To compare the differences in stroke volume (SV) and stroke volume index (SI) between Han and Korean-Chinese and to investigate the correlated risk factors. A total of 1 647 Han and 876 Korean-Chinese aged 10-80 years were investigated. SV, SI, cardiac output, cardiac output index, heart rate (HR), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI), and blood pressure were measured. SV/SI values in Korean-Chinese were lower than those in the Han of the same sex and age. Covariance analysis showed that, apart from the effect of sex, age and body mass index (BMI), the differences in SV and SI between the two cohorts were still significant (P<0.001). Multiple regression analysis revealed that the SV difference between the two ethnicities was affected (in descending order from a strong to weak correlation) by SVR, SVRI, HR, diastolic blood pressure, mean arterial pressure, BMI, and systolic blood pressure, while the SI difference was affected by SVR, SVRI, HR, mean arterial pressure, diastolic and systolic blood pressure, and BMI. The Fact that SV and SI in Korean-Chinese are lower than those in Han is related with higher SVR, HR and blood pressure in the Korean-Chinese.
  Biomedical and Environmental Sciences 06/2011; 24(3):249-54. · 1.35 Impact Factor
• Article: Effects of Salvia miltiorrhiza extracts on rat hypoxic pulmonary hypertension, heme oxygenase-1 and nitric oxide synthase.

  Ying Chen, Yingmao Ruan, Li Li, Yan Chu, Xinlin Xu, Qingzhi Wang, Xiaomei Zhou
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  ABSTRACT: To investigate the effects of Salvia miltiorrhiza (SM) extracts on the expression of heme oxygenase-1 (HO-1) and nitric oxide synthase (NOS) in small pulmonary arteries (SPAs) of rats with chronic hypoxia. After two weeks of hypoxia, rats were treated with diltiazem, and small, median, and large doses of SM extracts. The lungs were tested for the expression and distribution of HO-1, endothelial NOS (eNOS) and inducible NOS (iNOS) by using immunohistochemistry and Western blot method. Median and large doses of SM extracts significantly reduced hypoxia-induced media thickening in the SPAs (similar with diltiazem), recovered repaired ultrastructure injury, decreased HO-1 and iNOS levels, and increased eNOS expression in the SPAs. Median and large doses of SM extracts play significant roles in inhibiting structural remodeling in rats with hypoxic pulmonary hypertension. These effects might attribute to the suppression of HO-1 and iNOS, and the promotion of eNOS expression under the conditions of hypoxia.
  Chinese medical journal 06/2003; 116(5):757-60. · 0.86 Impact Factor