Xiao-Mei Zhao

Publications (2)2.47 Total impact

• Article: Association between IRS-2 G1057D polymorphism and risk of gastric cancer.

  Xiao-Mei Zhao, Jie Chen, Li Yang, Xuan Luo, Lin-Lin Xu, Dong-Xiao Liu, Su-Lan Zhai, Ping Li, Xue-Rong Wang
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  ABSTRACT: To investigate the relationship between insulin receptor substrate-2 (IRS-2) G1057D polymorphism and the risk of gastric cancer (GC) in a Chinese population. A case-control study with 197 GC patients and 156 age- and sex- matched control subjects was conducted. The genotypes of polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype frequencies of IRS-2 G1057D polymorphism in cases were obviously different from those in the control group (P = 0.031). Compared with GG genotype carriers, the risk for GC was significantly higher (adjusted odds ratio = 2.32, 95% CI: 1.03-5.23, P = 0.042) in the individuals with the IRS-2 DD genotype. Furthermore, stratified analysis was performed based on age, sex, smoking status and residence, but no significant difference between the two groups was found. In addition, no significant association between genotypes and clinicopathological features was observed either. This study demonstrates that IRS-2 G1057D is involved in susceptibility to GC, although further large-sample studies are still needed.
  World journal of gastrointestinal oncology. 01/2012; 4(1):9-15.
• Article: Association between ITGA2 C807T polymorphism and gastric cancer risk.

  Jie Chen, Nan-Nan Liu, Jia-Qi Li, Li Yang, Ying Zeng, Xiao-Mei Zhao, Lin-Lin Xu, Xuan Luo, Bin Wang, Xue-Rong Wang
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  ABSTRACT: To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay. The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P = 0.019). Compared with individuals with the wild genotype CC, subjects with the variant genotypes (CT + TT) had a significantly higher risk of gastric cancer (adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007). In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged > 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients. The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.
  World Journal of Gastroenterology 06/2011; 17(23):2860-6. · 2.47 Impact Factor