Xiu L Feng,
Qing T Liu,
Rui B Cao,
Bin Zhou,
Fang Q Wang, Wen L Deng,
Ya F Qiu,
Yu Zhang,
Hassan Ishag,
Zhi Y Ma,
Qi S Zheng,
Pu Y Chen
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ABSTRACT: The bursa of Fabricius (BF) is the central humoral immune organ unique to birds. Here, we isolated a novel bursal pentapeptide I (BPP-I), LGPGP, from BF. BPP-I could play inhibition effect on MCF-7 but not on CEF or Vero cell proliferation in vitro, and enhance antitumor factor p53 protein expression. Also, BPP-I stimulated antibody production in a dose-dependent manner in hybridoma cell. Furthermore, BPP-I could induce various immune responses in mice immunization experiments, including increase antibody production and cytokines IL-4 and IFN-γ level, and induce T-cell immunophenotyping. These results suggest that BPP-I is a potential immunomodulator of antitumor and immunity. The study could provide some novel insights on the probable candidate reagent for the antitumor and immune improvement.
Amino Acids 07/2011; 42(6):2215-22. · 3.25 Impact Factor
