Vivek K Gupta

University of Jammu, Jammu City, Kashmir, India

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Publications (182)150.9 Total impact

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    ABSTRACT: The thiopyrazole gave many new polycyclic thiopyranopyrazole-heterocycles when it was assembled with a variety of O-alkenylated/alkynylated salicylaldehydes and naphthaldehydes in Brønsted acidic ionic liquid, [Hmim]HSO4, via domino/Knoevenagel–hetero-Diels–Alder (DKHDA) reaction. The reaction is highly stereoselective and the work-up procedure required no chromatography of products in many cases.
    Tetrahedron Letters 10/2014; 55(44):6060-6064. · 2.40 Impact Factor
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    ABSTRACT: IUCr Journals CRYSTALLOGRAPHY JOURNALS ONLINE This open-access article is distributed under the terms of the Creative Commons Attribution Licence http://creativecommons.org/licenses/by/2.0/uk/legalcode, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. Acta Cryst. (2014). E70, o1098–o1099 Sharma et al. · C 19 H 21 FN 6 O 4 Crystal structure of 5,5 0 0 0 -[(4-fluorophenyl)-methylene]bis[6-amino-1,3-dimethyl-pyrimidine-2,4(1H,3H)-dione] In the title molecule, C 19 H 21 FN 6 O 4 , the dihedral angles between the benzene ring and essentially planar pyrimidine rings [maximum deviations of 0.036 (2) and 0.056 (2) Å ] are 73.32 (7) and 63.81 (8) . The dihedral angle between the mean planes of the pyrimidine rings is 61.43 (6) . In the crystal, N— HÁ Á ÁO hydrogen bonds link molecules, forming a two-dimensional network parallel to (001) and in combination with weak C—HÁ Á ÁO hydrogen bonds, a three-dimensional network is formed. Weak C—HÁ Á Á interactions and – interactions, with a centroid–centroid distance of 3.599 (2) Å are also observed.
    Acta Crystallographica Section E Structure Reports Online 09/2014; 70:1098-1099. · 0.35 Impact Factor
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    ABSTRACT: Asthma is characterized by persistent airway inflammation caused by over expression of pro-inflammatory immune response, predominantly by eosinophils and lymphocytes. Lymphocytes (CD4+ Th2) have been documented to be responsible for the pathogenesis of asthma by secreting Th2 cytokines and activating eosinophils, leading to airway hypersensitivity. Secretion of Th2 cytokines has been shown critical for the induction of the characteristic airway inflammation in humans and animal models of asthma. These cytokines influence the inflammatory response and lead to the pathological changes associated with asthma. In the present study, 10 azepino [2,1-b] quinazolone derivatives (R1 to R10) were synthesised and evaluated for their anti-asthmatic activity using a murine model of asthma. The compounds R2, R4, R6, R7 and R8 caused a notable decrease Th2 cytokine secretion and eosinophilia in asthma-induced animals. However, the decrease was highly significant in case of R8-treated animals. Crystal structure of R8 was made by X-ray crystallography. Molecular modelling studies were done for the compound R8 with transcription factors STAT6 and GATA3 which are the main transcription factors responsible for Th2 cell differentiation. Also the pharmacokinetics of R8 was carried out in mice after oral and intravenous administrations.
    Medicinal Chemistry Research 09/2014; 23(9). · 1.61 Impact Factor
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    ABSTRACT: A series of homoleptic and heteroleptic complexes: [Cd(fprdtc)2] (1), [Cd(fprdtc)2(1,10-phen)] (2), [Cd(fprdtc)2(2,2′-bipy)] (3), [Cd(bufdtc)2] (4), [Cd(bufdtc)2(1,10-phen)] (5), and [Cd(bufdtc)2(2,2′-bipy)] (6)(where fprdtc = N-furfuryl-N-propyldithiocarbamate; bufdtc = N-butyl-N-furfuryldithiocarbamate) have been prepared and characterized. A single crystal X-ray structural analysis was carried out for 2. Reduction in νC–N (thioureide) for the heteroleptic complexes (2, 3, 5, and 6) compared to that of homoleptic complexes (1 and 4) is attributed to the change in coordination number from four to six and steric effect exerted by 1,10-phenanthroline and 2,2′-bipyridine. The downfield shift of N13CS2 carbon signal for heteroleptic complexes from the chemical shift value of homoleptic complexes is also attributed to the increase in coordination number. Single crystal X-ray structure of 2 indicates that the mononuclear structure of 2 shows symmetric coordination of the dithiocarbamate ligands and a distorted octahedral geometry for cadmium, defined by an N2S4 donor set, results. In this crystal structure, most significant π–π interaction is also observed.
    Phosphorus Sulfur and Silicon and the Related Elements 09/2014; 189(9). · 0.60 Impact Factor
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    ABSTRACT: A series of new disubstituted diphenyldithiophosphate complexes of cadmium [{(ArO)2PS2}2Cd] (9–12) have been isolated in aqueous media while their donor stabilized adducts [{(ArO)2PS2}2Cd·2C5H5N] (13–16) [(Ar = 2,4-(CH3)2C6H3, 2,5-(CH3)2C6H3, 3,4-(CH3)2C6H3 and 3,5-(CH3)2C6H3)] have been isolated in chloroform. These newly synthesized complexes were characterized by elemental analyses, IR and NMR (1H, 13C and 31P) spectroscopic analyses. The dithiophosphate ligands are coordinated bidentate to the cadmium ion via the two thiolate sulfurs. The compounds [{(3,5-CH3)2C6H3O}2PS2HNEt3] (4) and [{(3,5-CH3)2C6H3O}2PS2]2Cd(NC5H5)2 (16) crystallize in the monoclinic system with space group P2 1 /c. Single-crystal X-ray analysis of 4 reveals that phosphorus of the anion is tetrahedrally bonded to two S and two O atoms. The structure is stabilized by cation–anion N–H…S intermolecular hydrogen bond interactions. In 16, two diphenyldithiophosphate ions are bidentate with both sulfurs coordinated to cadmium. Each forms a four-membered chelate ring in the equatorial plane. Two pyridines are axially coordinated to cadmium leading to octahedral geometry. The thermal properties of this complex have also been examined by combined DTA/DTG thermal analyses.
    Journal of Coordination Chemistry 09/2014; 67(17). · 1.80 Impact Factor
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    ABSTRACT: The coordination polymer (CP) of bis(3-pyridyl)butanediamide with Cu(ClO4)2 is a 2D network (CP-3-Cu), which showed two-fold parallel interpenetration, whereas with Cd(ClO4)2 it is a 1D network containing rectangular loops (CP-4-Cd). The metal metathesis of CP-4-Cd with Cu(II) resulted in the isomorphous replacement of the Cd(II) centre with Cu(II). Transmetallation reaction resulted in retaining the structural features of CP-4-Cd even in case of a flexible ligand. The CP formed via transmetallation couldn't be synthesized from a direct reaction of bis(3-pyridyl)butanediamide and Cu(ClO4)2. The transmetallation kinetic studies were performed with an atomic absorption spectrophotometer (AAS) and wavelength dispersive X-ray fluorescence (WDXRF).
    RSC Advances 08/2014; 4(69). · 3.71 Impact Factor
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    ABSTRACT: In the title compound, C17H18N4O4, the dihedral angle between the benzene ring and 2,4-di-hydro-pyrano[2,3-c]pyrazole ring system is 89.41 (7)°. The pyran moiety adopts a strongly flattened boat conformation. In the crystal, mol-ecules are linked by N-H⋯N, N-H⋯O, C-H⋯N and C-H⋯O hydrogen bonds into an infinite two-dimensional network parallel to (110). There are π-π inter-actions between the pyrazole rings in neighbouring layers [centroid-centroid distance = 3.621 (1) Å].
    Acta Crystallographica Section E Structure Reports Online 08/2014; 70(Pt 8):o875-6. · 0.35 Impact Factor
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    ABSTRACT: In the title compound, C17H18N4O4, the dihedral angle between the benzene ring and 2,4-dihydropyrano[2,3-c]pyrazole ring system is 89.41 (7)�. The pyran moiety adopts a strongly flattened boat conformation. In the crystal, molecules are linked by N—H� � �N, N—H� � �O, C—H� � �N and C— H� � �O hydrogen bonds into an infinite two-dimensional network parallel to (110). There are �–� interactions between the pyrazole rings in neighbouring layers [centroid–centroid distance = 3.621 (1) A ˚ ].
    Acta Crystallographica Section E Structure Reports Online 07/2014; E70:o875-o876. · 0.35 Impact Factor
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    ABSTRACT: In the asymmetric unit of the title compound, C16H14N4O3�- C2H6OS, there are two independent main molecules (A and B) and two dimethyl sulfoxide solvent molecules. In molecule A, the pyran ring is in a flattened sofa conformation, with the sp3-hydridized C atom forming the flap. In molecule B, the pyran ring is in a flattened boat conformation, with the sp3-hydridized C atom and the O atom deviating by 0.073 (3) and 0.055 (3) A ˚ , respectively, from the plane of the other four atoms. The mean planes the pyrazole and phenyl rings form dihedral angles of 84.4 (2) and 84.9 (2)�, respectively, for molecules A and B. In the crystal, N—H� � �O and N—H� � �N hydrogen bonds link the components of the structure into chains along [010]. In both solvent molecules, the S atoms are disordered over two sites, with occupancy ratios of 0.679 (4):0.321 (4) and 0.546 (6):0.454 (6).
    Acta Crystallographica Section E Structure Reports Online 06/2014; E70:o795-o796. · 0.35 Impact Factor
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    ABSTRACT: The compound 2-amino-5-oxo-4-p-tolyl-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile, crystallizes in the monoclinic space group P121/c1 with the unit-cell parameters: a= 9.1330(7), b= 13.1343(9), c= 13.1945(8) Å, β = 91.746(4)o and Z = 4. The crystal structure was solved by direct methods using single-crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedures to a final R-value of 0.0537 for 1830 observed reflections. The molecules within the unit cell are stabilized by C-H….O, N-H…O N-H….N and C-H…..π type of hydrogen bonding
    European Chemical Bulletin (ISSN 2063-5346). 05/2014; 3(7):654-657.
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    ABSTRACT: The 2-alkenylthiopyranoquinoline-3-carbaldehyde derived from 2-mercaptoquinoline-3-carbaldehyde and citral underwent smooth domino Knoevenagel/hetero-Diels–Alder reaction with heterocyclic mono- or diketones in tetrabutylammonium hydrogensulfate under solvent-free conditions and afforded a new class of thiochromenoquinoline-fused heterocycles in good yields. The reaction is highly diasteroselective and can be applied to analogues of carbocyclic diketones as well. The stereochemistry of the products was confirmed by single-crystal X-ray diffraction and 2D NMR NOESY data.
    Monatshefte fuer Chemie/Chemical Monthly 04/2014; 145:1179. · 1.63 Impact Factor
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    ABSTRACT: In the title compound, C22H21N3O2, the pyrimidine ring is essentially planar [maximum deviation = 0.018 (2) Å] and forms dihedral angles of 22.70 (8) and 0.97 (7)°, respectively, with the fused benzene ring and the hy-droxy-substituted benzene ring. The piperidine ring has a chair conformation and the pyran ring has a flattened twist-boat conformation. The hy-droxy group was refined as disordered over two sets of sites in a 0.702 (4):0.298 (4) ratio. The disorder corresponds to a rotation of approxomiately 180° about the C-C bond connecting the phenol group to the pyrimidine ring and hence, both the major and minor components of disorder form intra-molecular O-H⋯N hydrogen bonds. In the crystal, pairs of weak C-H⋯π inter-actions form inversion dimers. In addition, π-π inter-actions are observed between the pyrimidine ring and the hy-droxy-substituted benzene ring [centroid-centroid separation = 3.739 (2) Å].
    Acta Crystallographica Section E Structure Reports Online 04/2014; 70(Pt 4):o447-8. · 0.35 Impact Factor
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    ABSTRACT: The first nickel(II) complexes of disubstituted diphenyldithiophosphates have been isolated in quantitative yield and structurally characterized by elemental analyses, IR, NMR (1H, 13C and 31P) and single crystal X-ray analyses. A cyclic voltammetry experiment depicted a quasi-reversible and one electron redox process. The complexes depicted potential antifungal activities.
    Polyhedron 04/2014; 72:140–146. · 2.05 Impact Factor
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    ABSTRACT: The title compound, (Z)-1-(3-chlorophenyl)-4[1{(2hydroxyphenyl)amino}propylidene]-3-methyl-1H-pyrazol-5(4H)-one was synthesized by refluxing compound 1-(m-chlorophenyl)-3-methyl-4-propionyl-5-pyrazolone, with 2-aminophenol in ethanol. The compound crystallizes in the orthorhombic crystal system with space group Pca21 having unit cell parameters: a = 26.2993(8), b = 7.0724(2) and c = 18.7170(5)Å. The structure contains two crystallographically independent molecules, A, and, B, in the asymmetric unit cell. The crystal structure was solved by direct method using single crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedures to a final R- value of 0.049 for 5207 observed reflections.
    03/2014; 1591(1).
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    ABSTRACT: In the title compound, C30H40FNO3, the dihedral angle between the benzene rings is 57.76 (7)°. The alkyl chain adopts an all-trans conformation. In the crystal, mol-ecules are linked by pairs of C-H⋯O hydrogen bonds, forming inversion dimers.
    Acta Crystallographica Section E Structure Reports Online 03/2014; 70(Pt 3):o244. · 0.35 Impact Factor
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    ABSTRACT: In the title mol-ecule, C24H22N4O3, the plane of the oxa-diazole ring forms a dihedral angle of 32.41 (12)° with that of the phenyl ring and dihedral angles of 74.51 (10) and 56.38 (10)° with the planes of the benzene rings. In the crystal, pairs of N-H⋯N hydrogen bonds link molecules into inversion dimers featuring R 2 (2)(8) graph-set motifs.
    Acta Crystallographica Section E Structure Reports Online 03/2014; 70(Pt 3):o357-8. · 0.35 Impact Factor
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    ABSTRACT: In the title compound, C12H11Cl3N2O4, the dihedral angle between the aromatic ring and the hydrazine (NH-N=C) grouping is 52.2 (3)°. The butanedioate groups exhibit planar conformations. An intra-molecular N-H⋯O hydrogen bond links the N-H group of the hydrazine to one of the meth-oxy groups of the butane-dioate moiety. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds and π-π inter-actions are also observed [centroid-centroid separation = 3.535 (1) Å].
    Acta Crystallographica Section E Structure Reports Online 01/2014; 70(Pt 1):o13. · 0.35 Impact Factor
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    ABSTRACT: The title compound, 2-Phenyl-N-(pyrazin-2-yl)acetamide, C12H11N3O, was prepared by the coupling reaction and the product was crystallized by using toluene and methanol mixture(1:1) The structure of the compound was confirmed by elemental analysis, FTIR, 1H NMR, thermogravimetric analysis, differential thermal analysis, UV-Visible spectroscopy, and single-crystal X-ray diffraction. The compound crystallizes in the monoclinic space group P 21/c with the following unit-cell parameters: a = 8.1614(10), b = 14.9430(13), c = 9.3877(9) Å, β = 103.653(12)°, and Z = 4. The crystal structure was solved by direct methods using single-crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedures to a final R-value of 0.0465 for 1486 observed reflections. An intramolecular C-H···O hydrogen bond generates an S(6) graph-set motif. In the crystal, molecules are linked by N-H···O and C-H···O hydrogen bonds, forming a two-dimensional network.
    Molecular Crystals and Liquid Crystals 01/2014; 592(1). · 0.53 Impact Factor
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    ABSTRACT: 4-[(3-Acetylphenyl)amino]-2-methylidene-4-oxobutanoic acid (1) is synthesized by a ring opening reaction of itaconic anhydride with 3-aminoacetophenone and characterized by FT-IR, 1H NMR, UV-Vis, TGA, DTA, and single crystal X-ray diffraction. The crystal of 1 belongs to triclinic unit cell in the P-1 space group with the unit cell dimensions a = 4.9485(3), b = 5.3614(6), c = 22.457(2) Å, α = 88.295(8), β = 89.379(7), γ = 84.495(7), and Z = 2 The crystal structure is solved by direct methods using single-crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedures to a final R-value of 0.0467 for 1623 observed reflections. Intermolecular N-H …O and O-H …O hydrogen bonds links the molecules into chains along [010] direction. In addition the thermal stability of the 1 is determined by using DTA, TGA analysis, and wavelength absorption at λmax = 297 nm is determined by UV-Vis spectrophotometer.
    Molecular Crystals and Liquid Crystals 01/2014; 592(1). · 0.53 Impact Factor
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    ABSTRACT: Synthesis and crystal structure of the title compound octaaquadisodium bis(pyridine-2,3-dicarboxylato-N,O,O)copper(II), [Na2(H2O)8Cu(pydc)2]n having a three-dimensional network, is reported (H2pydc = pyridine-2,3-dicarboxylic acid). The compound was prepared by the hydrothermal method. The crystal structure was solved by direct methods using single-crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedures to a final R value of 0.0318 for 1,911 observed reflections. The compound has distorted octahedral geometry about the copper center due to Jahn–Teller distortion. The copper(II) is bonded to four symmetry-related quinolinate groups: two of them coordinate equatorially in a bidentate fashion through their nitrogen atom and one oxygen, O(1), from the 2-carboxylate group. The axial sites are provided by the other two carboxylates, through the oxygen atoms O(4) from the remaining 3-carboxylate group. Each pyridine-2,3-dicarboxylate (pydc) bridges copper(II) with sodium metal ion in a bidentate bridging mode of carboxylate group at 2-position of pydc. Each pydc also binds two different copper centers, which leads to the formation of a three-dimensional (3D) coordination polymer network. Two sodium ions are bridged through two water molecules and bonded to three more terminal water molecules. Hydrogen-bonding interaction involving water molecules and carboxylate groups strengthens the 3D network formed by the coordination polymer. The coordination polymer has a microporous structure, as is evident from the Brunauer–Emmett–Teller (BET) surface area of 5.42 m2/g. Graphical Abstract .
    Monatshefte fuer Chemie/Chemical Monthly 01/2014; · 1.63 Impact Factor

Publication Stats

133 Citations
150.90 Total Impact Points

Institutions

  • 1993–2014
    • University of Jammu
      • Department of Chemistry
      Jammu City, Kashmir, India
  • 2013
    • P.A. College of Engineering
      Mangalur, Karnātaka, India
  • 2012–2013
    • University of Mysore
      • Department of Chemistry
      Mahisūr, Karnātaka, India
    • Birla Institute of Technology and Science Pilani
      • Department of Chemistry
      Pilāni, Rajasthan, India
    • Sardar Patel University
      • Department of Chemistry
      Vallabh Vidyanagar, State of Gujarat, India
  • 2011–2012
    • The Maharaja Sayajirao University of Baroda
      • Department of Chemistry
      Vadodara, State of Gujarat, India