S Huh

University of Ulsan, Urusan, Ulsan, South Korea

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Publications (86)142.43 Total impact

  • H Kim, D Cho, D H Choi, W Park, S J Huh
    Annals of Oncology 05/2014; 25 Suppl 1:i6-i7. · 7.38 Impact Factor
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    ABSTRACT: We designed this study to evaluate the incidence of incidental findings on computed tomography (CT) scan implemented as simulation for adjuvant radiotherapy in breast cancer patients and to emphasize the need for careful review of simulation CT images before planning radiotherapy. A Resident and attending radiation oncologists retrospectively reviewed the medical records and simulation CT images of 776 patients treated with adjuvant radiotherapy at Samsung Medical Center during 2008. Previously undetected abnormal findings on simulation CT images were defined as incidental findings and interpreted by diagnostic radiologist. If the incidental findings required further evaluation or follow-up, they were defined as indeterminate findings. If subsequent cancers were diagnosed according incidental findings, they were defined as malignancy-related findings. There were 81 indeterminate findings (10.8%) including thyroid nodule, solitary pulmonary nodule, mediastinal lymph node, supraclavicular or axillary lymph node. Among them, there were nine malignancy-related findings (1.3%), including four thyroid cancers, three lung metastases, one primary lung cancer, and one axillary lymph node recurrence. The incidence of incidental findings in this study was low, but some of the findings were related to malignancy. Radiation oncologists should be alert to incidental findings on simulation CT, and incidental findings should be evaluated by diagnostic radiologists.
    Technology in cancer research & treatment 03/2014; · 1.94 Impact Factor
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    ABSTRACT: Background:To evaluate the effects of elective nodal irradiation (ENI) in clinical stage II-III breast cancer patients with pathologically negative lymph nodes (LNs) (ypN0) after neoadjuvant chemotherapy (NAC) followed by breast-conserving surgery (BCS) and radiotherapy (RT).Methods:We retrospectively analysed 260 patients with ypN0 who received NAC followed by BCS and RT. Elective nodal irradiation was delivered to 136 (52.3%) patients. The effects of ENI on survival outcomes were evaluated.Results:After a median follow-up period of 66.2 months (range, 15.6-127.4 months), 26 patients (10.0%) developed disease recurrence. The 5-year locoregional recurrence-free survival and disease-free survival (DFS) for all patients were 95.5% and 90.5%, respectively. Pathologic T classification (0-is vs 1 vs 2-4) and the number of LNs sampled (<13 vs 13) were associated with DFS (P=0.0086 and 0.0012, respectively). There was no significant difference in survival outcomes according to ENI. Elective nodal irradiation also did not affect survival outcomes in any of the subgroups according to pathologic T classification or the number of LNs sampled.Conclusions:ENI may be omitted in patients with ypN0 breast cancer after NAC and BCS. But until the results of the randomised trials are available, patients should be put on these trials.British Journal of Cancer advance online publication, 30 January 2014; doi:10.1038/bjc.2014.26 www.bjcancer.com.
    British Journal of Cancer 01/2014; · 5.08 Impact Factor
  • D. I. Shin, S. K. Joo, S. J. Huh
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    ABSTRACT: In this paper we propose new criteria to classify daily life activities using accelerometer and pulse oximeter. As a result, once the device decides in emergence, it sends a short message to server and then connected to the u-Healthcare center or emergency center and one's family.
    Proceedings of the 7th International Conference on Body Area Networks; 02/2012
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    ABSTRACT: In cervical cancer, the prognostic significance of bladder wall invasion on MRI without pathological evidence of mucosal invasion is not known. From 454 consecutive patients with cervical cancer who were treated with radiation, we reviewed images and analysed the outcome of 92 patients with the Federation of International Gynecology and Obstetrics (FIGO) stage IIIB-IVA. We analysed the patients in three groups, normal, wall (muscle and/or serosal) invasion and mucosal invasion, according to the findings on the MRI. Kaplan-Meier life table analysis and the log-rank test were used to assess the survival rates and differences according to prognostic factors. MRI detected abnormalities in the bladder wall in 42 patients (45.6%): wall invasion in 24 and mucosal invasion in 18. 5 of 18 patients, suspected on MRI to have mucosal invasion, showed no pathological evidence of mucosal invasion. Median follow-up period was 34 months. 3-year cause-specific survival (CSS) in the normal group compared with the wall invasion group was 76.2% vs 71.4% (p = 0.48). 3-year CSS for the wall invasion group compared with the mucosal invasion group was 71.4% vs 54.3% (p = 0.04). Mucosal invasion on MRI (p = 0.03) and concurrent chemoradiotherapy (p = 0.01) was significant for CSS. The prognosis for patients with cervical cancer with evidence of muscle and/or serosal invasion of the bladder on MRI may not differ from that for patients without abnormality on MRI. In patients with the MRI finding of bladder mucosal invasion, further studies should be conducted regarding the role of cystoscopy to determine the need for pathological confirmation.
    The British journal of radiology 10/2010; 83(994):868-73. · 2.11 Impact Factor
  • D. I. Shin, P. J. Pak, S. J. Huh
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    ABSTRACT: Health Level Seven (HL7) is the standard of electronic data interchange in the health domain. In This paper, we have developed mobile application with HL7 protocol. This application, data are transmitted the bio-signal like SpO2 from sensor to mobile phone through serial communication. The mobile phone convert raw data to HL7 formed data and send it to other PCs by Bluetooth or WLAN. KeywordsMobile-HL7-uHealthcare-Embedded System
    01/2010: pages 110-111;
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    ABSTRACT: Remote Monitoring System of Deep Freezer takes charges of biological microbe or any samples for experiments safely. Compared with system of deep freezer from II. DIAGRAM FOR REMOTE MONITORING SYSTEM other manufacturers, deep freezer with remote monitoring system shows time-table of temperature through program LabVIEWTM and saves the data. If deep freezer’s temperature is higher than setting degree, it automatically announces this situation to the clerk in charge by text message. Then, the clerk would be possible for monitoring deep freezers through web. If using this system, it’s possible to cope with any problems of deep freezer and actualize condition-based maintenance (CBM) through collecting the historical data and analyzing them. KeywordsDeep Freezer-Remote Monitoring-SMS
    01/2010: pages 27-29;
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    ABSTRACT: A remote monitoring system for the light source of endoscope systems was developed. The light source is an essential part of endoscope system. To manage these light sources more efficiently, we proposed a remote monitoring system that provides information about the light sources of endoscope system dispersed in the hospital. The illumination and temperature data of each light source were sent to the local monitoring computer and the information like duration of lamp use, the frequency of lamp use, internal temperature of the device, and replacement time of the lamp were displayed and stored. This device enables the estimation the current condition of the lamp as well as optimal replacement time of the lamp. Furthermore, the calculation of accumulated data enables condition based management (CBM).
    01/2010;
  • Fuel and Energy Abstracts 01/2010; 78(3).
  • H. Nam, S. Huh, S. Ju, J. Choi, B. Kim
    Fuel and Energy Abstracts 01/2010; 78(3).
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    ABSTRACT: Technical limitations and evolution of therapeutic applications for cell culture-derived products have accelerated elimination of animal-derived constituents from such products to minimize inadvertent introduction of microbial contaminants, such as fungi, bacteria or viruses. The study described here was conducted to investigate the proliferative effect of vegetable peptone on adult stem cells in the absence of serum, and its possible mechanisms of action. Cell viability and proliferation were determined using the MTT assay and Click-iT EdU flow cytometry, respectively. In addition, changes in expression of cytokine genes were analysed using MILLIPLEX human cytokine enzyme-linked immunosorbent assay kit. Viability of cord blood-derived mesenchymal stem cells (CB-MSC) and adipose tissue-derived stem cells (ADSC) increased significantly when treated with the peptone. In addition, median value of the group treated with peptone shifted to the right when compared to the untreated control group. Furthermore, quantitative analysis of the cytokines revealed that production of vascular endothelial growth factor (VEGF), transforming growth factor-beta1 (TGF-beta1), and interleukin-6 (IL-6) increased significantly in response to treatment with our vegetable peptone in both CB-MSCs and ADSCs. Our findings revealed that the vegetable peptone promotes proliferation of CB-MSCs and ADSCs. In addition, results of this study suggest that induction of stem cell proliferation by vegetable peptone is likely to be related to its induction of VEGF, TGF-beta1, and IL-6 expression.
    Cell Proliferation 08/2009; 42(5):595-601. · 2.27 Impact Factor
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    ABSTRACT: In patients with human epidermal growth factor receptor-2 (HER2)-overexpressing breast cancer, treatment with trastuzumab has been shown to markedly improve the outcome. We investigated the role of trastuzumab on brain metastasis (BM) in HER2-positive breast cancer patients. From 1999 to 2006, 251 patients were treated with palliative chemotherapy for HER2-positive metastatic breast cancer at Samsung Medical Center. The medical records of these patients were analysed to study the effects of trastuzumab on BM prevalence and outcomes. Patients were grouped according to trastuzumab therapy: pre-T (no trastuzumab therapy) vs post-T (trastuzumab therapy). The development of BM between the two treatment groups was significantly different (37.8% for post-T vs 25.0% for pre-T, P=0.028). Patients who had received trastuzumab had longer times to BM compared with patients who were not treated with trastuzumab (median 15 months for post-T group vs 10 months for pre-T group, P=0.035). Time to death (TTD) from BM was significantly longer in the post-T group than in the pre-T group (median 14.9 vs 4.0 months, P=0.0005). Extracranial disease control at the time of BM, 12 months or more of progression-free survival of extracranial disease and treatment with lapatinib were independent prognostic factors for TTD from BM.
    British Journal of Cancer 03/2009; 100(6):894-900. · 5.08 Impact Factor
  • Ejc Supplements - EJC SUPPL. 01/2009; 7(2):314-314.
  • International Journal of Radiation Oncology Biology Physics - INT J RADIAT ONCOL BIOL PHYS. 01/2008; 72(1).
  • P.J. Pak, D I Shin, S J Huh
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    ABSTRACT: Health Level Seven (HL7) is the standard of electronic data interchange in the health domain. In This paper, we suggest abstract structure algorithm for modeling HL7 message. Compared with other existing ones, this method optimized uHealthcare environment. When updating HL7 message structure, there is no need to compile entire code. Besides, no speed down results from repetitive request queries.
    Information Technology Applications in Biomedicine, 2007. ITAB 2007. 6th International Special Topic Conference on; 12/2007
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    ABSTRACT: Increased production and accumulation of melanin is characteristic of a large number of skin diseases, including acquired hyperpigmentation such as melasma, postinflammatory melanoderma and solar lentigo. Thus, there is a increasing need for the development of depigmenting agents. To evaluate the depigmenting capacity of 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF) and to elucidate the mechanisms by which it inhibits alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanogenesis in B16 melanoma cells in vitro. Several experiments were performed in B16 melanoma cells. We studied melanin content, tyrosinase activity and cAMP production, and performed cAMP response element (CRE) luciferase reporter assay and Western blots for proteins involved in melanogenesis. The melanin content and tyrosinase activity induced by alpha-MSH were inhibited significantly by DMHF. To clarify the mechanism of the depigmenting property of DMHF, we examined the involvement of DMHF in cAMP signalling induced by alpha-MSH. In CRE luciferase reporter assay, CRE reporter activation induced by alpha-MSH was inhibited by DMHF. Additionally, although DMHF did not inhibit cAMP production by alpha-MSH, both CRE binding protein (CREB) phosphorylation and the reduction of glycogen synthase kinase-3beta phosphorylation by alpha-MSH were blocked by DMHF. These data suggest that DMHF inhibits the downstream step of cAMP production induced by alpha-MSH, consequently inhibiting melanogenesis. This suggestion was further confirmed by the fact that the increased production levels of microphthalmia-associated transcription factor, tyrosinase and tyrosinase-related protein-1 induced by alpha-MSH were all reduced by DMHF in B16 melanoma cells. Our study shows that DMHF inhibits alpha-MSH-induced melanogenesis by suppressing CREB phosphorylation, which is induced by protein kinase A, and suggests that DMHF may be an effective inhibitor of hyperpigmentation.
    British Journal of Dermatology 09/2007; 157(2):242-8. · 3.76 Impact Factor
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    ABSTRACT: We have created a pilot wireless network for the convenient monitoring of temperature and humidity of infant incubators. This system combines infrared and radio frequency (RF) communication in order to minimize the power consumption of slave devices, and we therefore call it a hybrid wireless network. The slave module installed in the infant incubator receives the calling signal from the host with an infrared receiver, and sends temperature and humidity data to the host with an RF transmitter. The power consumption of the host system is not critical, and hence it uses the maximum power of infrared transmission and continuously operating RF receiver. In our test implementation, we included four slave devices. The PC calls each slave device every second and then waits for 6 s, resulting in a total scan period of 10 s. Slave devices receive the calling signals and transmit three data values (temperature, moisture, and skin temperature); their power demand is 1 mW, and can run for about 1000 h on four AA-size nickel-hydride batteries.
    Medical Engineering & Physics 11/2005; 27(8):713-6. · 1.78 Impact Factor
  • International Journal of Radiation OncologyBiologyPhysics 10/2005; 63. · 4.52 Impact Factor
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    ABSTRACT: To evaluate the efficacy and toxicity of consolidation chemotherapy after concurrent chemoradiation (CCRT) with 5-fluorouracil (5-FU) and cisplatin in the treatment of high-risk, early stage cervical carcinoma after radical surgery. Women with clinical stage IB and IIA cervical carcinoma, initially treated with radical hysterectomy and pelvic lymphadenectomy, and who had positive pelvic lymph nodes, positive margins, parametrial involvement, or all three, were divided into either a CCRT alone group or a consolidation chemotherapy after CCRT group. Three cycles of chemotherapy were given to the CCRT alone group, and six cycles to the consolidation chemotherapy group. Women in each group received 50.4 Gy external radiation in 28 fractions to a standard pelvic field. Chemotherapy consisted of cisplatin 60 mg/m2 (X 1) and 5-FU 1000 mg/m2/d (X 5) every 3 weeks, with the first and second cycles given concurrent with radiation. Survival and toxicity were compared between the two groups. Forty women were evaluable (25 in the CCRT alone group and 15 in the consolidation chemotherapy group). The estimated 2-year progression-free survival was 87.7% in the CCRT alone group and 67.0% in the consolidation chemotherapy group. The estimated 2-year overall survival was 95.8% in the CCRT alone group and 100% in the consolidation chemotherapy group. However, no significant differences were found in progression-free and overall survival in the two groups (P = 0.17 and P = 0.29, respectively). Grade 2 or higher leukopenia and neutropenia were significantly more frequent in the consolidation chemotherapy group than in the CCRT alone group (P = 0.02 and P < 0.01, respectively). Although the sample size was small, and this study was not randomised, these results suggest that consolidation chemotherapy may not improve survival. Rather, it may increase haematologic toxicities for women with high-risk, early stage cervical carcinoma who undergo radical surgery followed by CCRT.
    Clinical Oncology 10/2005; 17(6):412-7. · 2.86 Impact Factor
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    ABSTRACT: Alveolar soft part sarcoma (ASPS) of the vagina is an exceptionally rare neoplasm. Furthermore, vaginal metastasis of ASPS has not been reported. A 28-year-old woman with a history of a right thigh mass diagnosed as ASPS excised 8 years ago presented to the emergency room with massive vaginal bleeding and anemia. Biopsy of a vaginal mass revealed that the tumor was a vaginal metastasis of ASPS. For control of intractable bleeding and preventing further transfusions, palliative radiation therapy was planned. She received a total of 39 Gy (daily 3 Gy, using 15-MV photons), and after 6-Gy irradiation, there was no more vaginal bleeding and no more transfusion needed. This is the first case of vaginal metastasis of ASPS reported in the literature that was manifested by intractable vaginal bleeding, which was controlled successfully with radiation therapy.
    International Journal of Gynecological Cancer 01/2005; 15(6):1166-8. · 1.94 Impact Factor

Publication Stats

586 Citations
142.43 Total Impact Points

Institutions

  • 2007–2012
    • University of Ulsan
      Urusan, Ulsan, South Korea
  • 2005–2010
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2001–2004
    • Sungkyunkwan University
      • Department of Radiation Oncology
      Sŏul, Seoul, South Korea
  • 1999
    • Chung-Ang University Hospital
      Sŏul, Seoul, South Korea
    • Kangwon National University
      • Department of Biology
      South Korea
  • 1990–1999
    • Hallym University
      • College of Medicine
      Seoul, Seoul, South Korea
  • 1998
    • Konkuk University
      Sŏul, Seoul, South Korea
  • 1996–1998
    • Samsung Medical Center
      • Department of Radiation Oncology
      Seoul, Seoul, South Korea
  • 1988–1996
    • Seoul National University
      • College of Medicine
      Sŏul, Seoul, South Korea
  • 1992
    • Soonchunhyang University
      Onyang, South Chungcheong, South Korea