Saino Hanna Varghese

Toyo University, Tōkyō, Japan

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Publications (7)15.61 Total impact

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    ABSTRACT: The targeting and therapeutic efficacy of dye- and dual-drug-loaded silica nanoparticles, functionalized with triple targeting ligands specific towards cancer and neoangiogenesis simultaneously, are discussed. This synergized, high-precision, multitarget concept culminates in an elevated uptake of nanoparticles by cancer and angiogenic cells with amplified proficiency, thereby imparting superior therapeutic efficacy against breast cancer cells and completely disabling the migration and angiogenic sprouting ability of activated endothelial cells. The exceptional multimodal efficiency achieved by this single therapeutic nanoformulation holds promise for the synergistic targeting and treatment of the yet elusive cancer and its related angiogenesis in a single, lethal shot.
    Small 08/2012; · 7.82 Impact Factor
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    ABSTRACT: We discuss about the utilization of functionalized electrophoretic deposition technique for photovoltaic application encompassing the prospective potential of both functionalization and electrophoretic deposition. We report the fabrication of TiO2 sensitized electrode by electrophoretic deposition of CdSe quantum dots. This method holds the advantage of achieving effective coating of CdSe onto TiO2 electrode by reducing the deposition time to 15 min. Cross-sectional and depth profile elemental analysis revealed the even distribution of CdSe across the TiO2 layer. Ninety percentage of light harvesting efficiency was achieved for the CdSe sensitized electrode affirming the efficacy of sensitization by functionalized electrophoretic deposition.
    Chemical Physics Letters 05/2012; 539–540(29 June 2012):197–203. · 2.15 Impact Factor
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    ABSTRACT: Design of blood compatible surfaces is required to minimize platelet surface interactions and increase the thromboresistance of foreign surfaces when they are used as biomaterials especially for artificial blood prostheses. In this study, single wall carbon nanotubes (SWCNTs) and Zein fibrous nanocomposite scaffolds were fabricated by electrospinning and evaluated its antithrombogenicity and hydrophilicity. The uniform and highly smooth nanofibers of Zein composited with different SWCNTs content (ranging from 0.2 wt% to 1 wt%) were successfully prepared by electrospinning method without the occurrence of bead defects. The resulting fiber diameters were in the range of 100-300 nm without any beads. Composite nanofibers with and without SWCNT were characterized through a variety of methods including scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and tensile mechanical testing. The water uptake and retention ability of composite scaffolds decreased whereas thermal stability increased with an addition of SWCNTs. Hemolytic property and platelet adhesion ability of the nanocomposite (Zein-SWCNTs) were explored. These observations suggest that the novel Zein-SWCNTs composite scaffolds may possibly hold great promises as useful antithrombotic material and promising biomaterials for tissue engineering application.
    International Journal of Biomaterials 01/2012; 2012:345029.
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    ABSTRACT: Nano Drug Delivery, as a treatment method against brain tumors, is a progressing area in the field of precise targeted drug administration methodology. The unresolved problems related to chemotherapy, other invasive therapeutic procedures and various obstructions offered by biological barriers are circumvented by nanodrug delivery. Recent dramatic developments in nanotechnology have created a lot of nano-devices which could be used against cancer. Infiltration, modulation of the Blood Brain Barrier, camouflaged from immune defense mechanism and the specific targeting of cancer affected cells are a few of the attractive features of nanodevices. We present here a review of newly evolved nanoplatforms in brain tumor therapy in which careful attention has been paid into various form nanoparticles, useful targeting ligands, altered chemotherapy agents and existing tumor therapy methods using nanotechnology.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 06/2011; 7(5):488-503. · 1.64 Impact Factor
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    ABSTRACT: Sensors play a significant role in everyday life. Nowadays, there has been a strong demand for highly selective, sensitive, responsive, stable and cost effective sensors. As a result, research emphasis is on developing new sensing materials and technologies. Carbon nanotubes (CNTs) have many distinct properties that may be exploited to develop next generation of sensors. They exhibit extraordinary strength and unique combination of excellent mechanical, electrical, thermal, optical and electrochemical properties even in its small dimension nature, which has generated increasing interest in the application of CNTs as sensors. The main thrust of this review is to highlight the present and future research and development work in the area of CNT based sensors. Different types of sensors such as biosensors, chemical sensors, mass sensors, temperature sensors, strain sensors and pressure sensors based on CNTs are also discussed in detail. This manuscript concludes with an outline of the advantages of these CNT based sensors for real-world applications. This review aims to act as a reference source for researchers to help them in developing new applications of sensors based on CNTs.
    Current Nanoscience 07/2010; 6(4):331-346. · 1.36 Impact Factor
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    ABSTRACT: The successful application of various nanoplatforms in medicine under in vitro conditions has generated some interest in agri-nanotechnology. This technology holds the promise of controlled release of agrochemicals and site targeted delivery of various macromolecules needed for improved plant disease resistance, efficient nutrient utilization and enhanced plant growth. Processes such as nanoencapsulation show the benefit of more efficient use and safer handling of pesticides with less exposure to the environment that guarantees ecoprotection. The uptake efficiency and effects of various nanoparticles on the growth and metabolic functions vary differently among plants. Nanoparticle mediated plant transformation has the potential for genetic modification of plants for further improvement. Specifically, application of nanoparticle technology in plant pathology targets specific agricultural problems in plant–pathogen interactions and provide new ways for crop protection. Herein we reviewed the delivery of nanoparticulate materials to plants and their ultimate effects which could provide some insights for the safe use of this novel technology for the improvement of crops.
    Plant Science. 01/2010;
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    ABSTRACT: Poly (ethylene terephthalate) (PET) was surface modified by plasma polymerization of acetobromo-alpha-D-glucose (ABG) at different radio frequency (RF) powers. Plasma polymerization was carried out by vaporizing ABG in the powder form by heating at 135 degrees C. Surface modification resulted in improved hydrophilicity and smoothness of the surface especially at low RF powers (30-50 W), but at high RF powers, the surface was found to be etched and the hydrophilicity decreased as evidenced by atomic force microscopy (AFM) and contact angle measurements. The plasma polymerized ABG film was found to be extensively cross-linked as evidenced by its insolubility in water. Infra red (IR) and X-ray photoelectron spectroscopy (XPS) were employed to characterize the plasma polymerized ABG films. IR studies revealed that at lower RF powers, polymerization was taking place mainly by breaking up of acetoxy group while retaining the ring structures to a major extent during the polymerization process whereas at high RF powers, the rupture of ring structures was indicated. XPS indicated a reduction in the percentage of oxygen in the polymers going from low to high RF powers suggestive of complete destruction of the acetoxy group at high RF powers. Cross-cut tests showed excellent adhesive properties of the plasma polymerized ABG films onto PET. Static platelet adhesion tests using platelet rich human plasma showed significantly reduced adhesion of platelets onto modified PET surface as evidenced by scanning electron microscopy. Polymerization of glucose and its derivatives using RF plasma has not been reported so far and the preliminary results reported in this study shows that this could be an interesting approach in the surface modification of biomaterials.
    Journal of Biomaterials Applications 03/2009; 24(6):527-44. · 2.64 Impact Factor