[show abstract][hide abstract] ABSTRACT: Familial adenomatous polyposis is characterized by the development of multiple (>100) colorectal adenomas throughout the colorectum. This disorder can be caused by a germline mutation in the adenomatous polyposis coli gene and can be diagnosed either clinically or genetically. After diagnosis with the condition, patients should undergo prophylactic proctocolectomy with a neoreservoir, usually an ileoanal pouch, at an appropriate time. Individuals with a family history of this disease who have not been diagnosed should be advised to attend genetic counseling and to enroll in appropriate clinical and genetic surveillance programs. Recent progress in endoscopic technology, including high-resolution endoscopy, capsule endoscopy, and double-balloon endoscopy, has made possible more detailed and wide-ranging investigation of the gastrointestinal tract. Although there has been limited evidence, further studies on these new endoscopic technologies might alter the surveillance strategies for familial adenomatous polyposis.
European journal of gastroenterology & hepatology 10/2013; · 1.66 Impact Factor
[show abstract][hide abstract] ABSTRACT: Endoscopic techniques for the treatment of postoperative fistulae and leaks are rapidly developing. Conventional surgical therapy for postsurgical leaks and fistulae is associated with significant morbidity and mortality. Novel endoscopic therapies have demonstrated safety, despite the inherent challenges of intervention in this patient population, and are steadily building evidence for efficacy relative to surgical management. The article examines endoscopic therapy for leaks and fistulae after esophageal, gastric, bariatric, colonic, and pancreaticobiliary surgery.
Gastrointestinal endoscopy clinics of North America 01/2013; 23(1):123-36.
[show abstract][hide abstract] ABSTRACT: As more patients undergo bariatric surgery, gastroenterologists will increasingly encounter variant postsurgical anatomies and postoperative complications. We discuss the diagnosis and management of bleeding, ulcers, foreign bodies, stenoses, leaks, fistulas, pancreaticobiliary diseases, weight regain, and dilated outlets.
Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 11/2012; · 5.64 Impact Factor
[show abstract][hide abstract] ABSTRACT: Gastroenterologists will likely play a critical role in the treatment of obesity and its comorbidities, as novel endoluminal approaches demonstrate their safety and efficacy over the coming years. Understanding the relative advantages and shortcomings of the endoscopic tools and procedures currently under investigation will provide the gastroenterologist with valuable insight into the future of endoscopic procedures for weight loss.
Endoscopic restrictive procedures, intestinal sleeves, and intragastric balloons have demonstrated short-term efficacy in inducing weight reduction and in reversing the comorbidities of obesity with an acceptable risk profile. Several endoscopic tools have also demonstrated effectiveness as revisional tools for reversing weight gain after bariatric surgery.
A plethora of endoscopic tools and procedures are under investigation for primary and revisional obesity management, and these may offer new weight loss options to a variety of different patient populations.
Current opinion in gastroenterology 09/2011; 27(5):407-11. · 4.33 Impact Factor