Mine Durukan

Publications (7)7.1 Total impact

• Article: Low plasma renin activity and high aldosterone/renin ratio are associated with untreated isolated systolic hypertension.

  Mine Durukan, Umit Guray, Tolga Aksu, Yesim Guray, Burcu Demirkan, Sule Korkmaz
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  ABSTRACT: Abstract Objective. Isolated systolic hypertension (ISH) is generally encountered in elderly patients and there are scarce data regarding the renin-angiotensin-aldosterone system (RAAS) activity in patients with ISH. We aimed to determine the plasma renin activity (PRA), plasma aldosterone levels (PAL) and aldosterone/PRA ratio (PAL/PRA) in patients (age >50 years) with ISH and to compare these values with patients with essential hypertension (EH) as well as subjects with normal blood pressure values (control) who have similar age and cardiovascular risk profile. Methods. Consecutively, 42 untreated ISH patients, 30 patients with EH and 29 normal subjects were included in the study. Parameters were presented as median (interquartile range). Results. There were no significant differences regarding age, gender and other cardiovascular risk factors among groups. As expected, systolic, diastolic blood pressure and pulse pressure values were significantly different among groups. Besides, PRA values were found to be significantly lower in patients with ISH (0.4 [0.2-1.1] ng/ml/h) compared with the EH (0.95 [0.5-2.6] ng/ml/h, p =0.024) and control (1.3 [0.7-2.1] ng/ml/h, p =0.001) groups. Although, PAL were similar among groups, PAL/PRA ratio was significantly higher in ISH group (134.1 [73-224]) compared with those with EH (42.2 [35-84], p <0.001) and the control group (53.3 [30-106], p =0.001). No significant difference was present with respect to PAL/PRA ratio between EH and control groups. Conclusions. Our findings suggested that in patients with ISH, despite lower PRA levels, PAL/PRA ratio is significantly higher compared with the patients with EH and subjects with normal blood pressure. Since higher PAL/PRA levels is an indicator of relative aldosterone excess, medications blocking RAAS activity including aldosterone antagonists may have useful cardiovascular consequences in addition to their antihypertensive effects in ISH.
  Blood pressure 05/2012; 21(5):320-5. · 1.26 Impact Factor
• Article: Use of the mechanical dilator sheath for removal of endocardial leads: a single center experience.

  Tolga Aksu, Umit Guray, Taner Sen, Mine Durukan, Yesim Guray, Burcu Demirkan, Halil Kisacik
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  ABSTRACT: Due to an increasing number of cardiac device implantations, the number of leads that need to be extracted because of infection or lead failure is consistently rising. We present our experience in percutaneous lead removal in a single tertiary center. From December 2009 to August 2010, 12 patients underwent percutaneous lead extraction procedure by the Evolution™ mechanical dilator sheath (Cook Medical Inc., Bloomington, IN, USA) system after failure of manual traction and a locking stylet. Ages of the patients ranged between 7 and 86 years (mean age was 58 ± 12 years). Mean implantation time was 73 months (range between 12 and 244 months). Ten patients had one lead; only two patients had two leads. Indications for lead removal were: lead endocarditis in five patients, local (pocket) infection in four patients, and lead failure in three patients. All leads were successfully removed by using the device, except one lead which was one of the two leads in a patient with dual chamber pacemaker implanted 10 years ago. In three patients, same venous accesses (sheath of extraction system) were used to implant a new lead after removal of damaged leads without a new venous puncture. In only one patient, significant hematoma was found after the intervention and treated conservatively. No other significant complications were encountered in any patients. Damaged or infected leads can safely and relatively easily be extracted by using this new percutaneous extraction technique.
  Pacing and Clinical Electrophysiology 02/2012; 35(5):514-8. · 1.35 Impact Factor
• Article: [Augmentation of vessel narrowing by nitroglycerine in a case with myocardial bridge].

  Mine Durukan, Tolga Aksu, Ayşe Çolak, Ümit Güray
  Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 08/2011; 11(5):464-6. · 0.44 Impact Factor
• Article: High Ventricular Lead Impedance of a DDD Pacemaker after Cranial Magnetic Resonance Imaging.

  Kazim Baser, Umit Guray, Mine Durukan, Burcu Demirkan
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  ABSTRACT: Management of electromagnetic interference in the form of magnetic resonance imaging (MRI) in patients with pacemakers (PMs) may be challenging. Serious consequences, especially in PM-dependent patients, may be encountered. Changes in device programming, asynchronous pacing, heating of the lead tip(s), and increased thresholds or even device dislocation may be experienced. We report of a patient with a DDD PM who underwent an emergent MRI, after which there was an increase in ventricular impedance as well as increased cardiac biomarkers. (PACE 2012; 35:e251-e253).
  Pacing and Clinical Electrophysiology 02/2011; 35(9):e251-3. · 1.35 Impact Factor
• Article: [Extraction of a large vegetation and ICD lead using the Evolution Mechanical Dilator Sheath].

  Tolga Aksu, Mine Durukan, Umit Güray, Ayşe Colak
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  ABSTRACT: A 74-year-old male patient presented with complaints of fatigue, fever, and worsening health status. He had a 34-month history of cardioverter-defibrillator (ICD) implantation due to ischemic cardiomyopathy. Transthoracic and transesophageal echocardiography showed a mobile mass, 24 x 11 mm in size, consistent with a vegetation attached to the right ventricular ICD lead. Surgical removal of the electrode was considered to be highly risky for the patient, thus percutaneous removal was decided. Due to adhesions, manual traction of the lead with a standard stylet was ineffective. Complete lead extraction was accomplished using the Evolution Mechanical Dilator Sheath, which is a new mechanical sheath with a stainless steel bladed tip. No complications occurred during or after the procedure. Following a histopathologic diagnosis of vegetation, the patient received a six-week antibiotic therapy, after which a new ICD was implanted on the contralateral side. To our knowledge, this case represents the largest lead vegetation extracted by this new device. Although its safety should be validated by increasing number of cases, it seems that its simple use would make this device a new interesting tool among the instruments available for lead extraction.
  Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 01/2011; 39(5):403-6.
• Article: Implantable Cardioverter Defibrillator Lead Endocarditis Causing Diffuse Right Atrial Abscess and Pulmonary Artery Embolism

  ÜMIT KERVAN M.D, GARIP ALTINTAS M.D, ANIL OZEN M.D, MINE DURUKAN, ÜMIT GURAY M.D, MEHMET ALI ÖZATIK M.D
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  ABSTRACT: Implantation of electrophysiological cardiac devices such as pacemakers and implantable cardioverter defibrillators has become a widely available and routine procedure in cardiovascular medicine. One of the most feared complications of device implementation is infection. Infection rates for these devices are reported to vary between 0.7% and 7.0%. Cardiac thromboembolic event is a recognized complication of permanent cardiac rhythm devices with an incidence of 0.6%–3.5%, unrelated to lead size or number. These complications are associated with high morbidity and mortality rates. In this case report, right atrial mass, right atrial abscess, perforation of tricuspid septal leaflet, and pulmonary embolism secondary to ICD lead endocarditis is presented. (PACE 2011; 34:e115–e117)
  Pacing and Clinical Electrophysiology 07/2010; 34(12):e115 - e117. · 1.35 Impact Factor
• Article: Implantable cardioverter defibrillator lead endocarditis causing diffuse right atrial abscess and pulmonary artery embolism.

  Ümit Kervan, Garip Altintas, Anil Ozen, Mine Durukan, Ümit Guray, Mehmet Ali Özatik
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  ABSTRACT: Implantation of electrophysiological cardiac devices such as pacemakers and implantable cardioverter defibrillators has become a widely available and routine procedure in cardiovascular medicine. One of the most feared complications of device implementation is infection. Infection rates for these devices are reported to vary between 0.7% and 7.0%. Cardiac thromboembolic event is a recognized complication of permanent cardiac rhythm devices with an incidence of 0.6%-3.5%, unrelated to lead size or number. These complications are associated with high morbidity and mortality rates. In this case report, right atrial mass, right atrial abscess, perforation of tricuspid septal leaflet, and pulmonary embolism secondary to ICD lead endocarditis is presented.
  Pacing and Clinical Electrophysiology 07/2010; 34(12):e115-7. · 1.35 Impact Factor