Lu-Qing Li

Publications (2)3.7 Total impact

• Article: Lignans from the heartwood of Streblus asper and their inhibiting activities to hepatitis B virus.

  Lu-Qing Li, Jun Li, Yan Huang, Qiang Wu, Sheng-Ping Deng, Xiao-Jian Su, Rui-Yun Yang, Ji-Guo Huang, Zi-Zhan Chen, Shan Li
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  ABSTRACT: Three new lignans, erythro-strebluslignanol (1), threo-7'-methoxyl strebluslignanol (2) and erythro-7'-methoxyl strebluslignanol (3), together with twelve known compounds were isolated from the n-butanol and chloroform fractions of the heartwood of Streblus asper. Their structures were elucidated through extensive spectroscopic methods, including MS and 2D NMR experiments (HMQC and HMBC). The stereochemistry at the chiral center was determined using CD spectra, as well as analysis of coupling constants and optical rotation data, respectively. Primary bioassays showed that 6-hydroxyl-7-methoxyl-coumarin (5) and ursolic acid (10) showed anti-HBV activities, with IC(50) values of 29.60 μM and 89.91 μM for HBsAg at no cytotoxicity, and IC(50) values of 46.41 μM and 97.61 μM for HBeAg at no cytotoxicity, respectively.
  Fitoterapia 11/2011; 83(2):303-9. · 1.85 Impact Factor
• Article: Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase.

  Shan Li, Jian Li, Xin-Lan Guan, Jun Li, Sheng-Ping Deng, Lu-Qing Li, Mao-Tong Tang, Ji-Guo Huang, Zi-Zhan Chen, Rui-Yun Yang
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  ABSTRACT: The various fractions of the barks of Cyclocarya paliurus were systematically tested for hypoglycemic effects in alloxan-induced diabetic rats. The results showed that the chloroform fraction of the 75% EtOH extract of the barks of this plant exhibited significant blood sugar reducing activity, most of which were significantly higher than that of positive-drug metformin hydrochloride. A new compound, together with nine known compounds, was isolated from the most active fraction. The structure elucidation was based on spectroscopic methods, including two-dimensional NMR experiments (¹H-¹H COSY, HMQC, and HMBC). All of the isolates were evaluated for their α-glycosidase and glycogen phosphorylase inhibitory activities.
  Fitoterapia 07/2011; 82(7):1081-5. · 1.85 Impact Factor