Publications (1)4.47 Total impact
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Article: Synthesis of salinosporamide A and its analogs as 20S proteasome inhibitors and SAR summarization.
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ABSTRACT: Salinosporamide A (4), a secondary metabolite of the marine actinomycete Salinispora tropica, is a potent inhibitor of 20S proteasome that is currently in clinical trials for the treatment of cancers. Herein, we described various synthetic strategies of 4 and summarized the SAR of 4 and its analogs.Current topics in medicinal chemistry 08/2011; 11(23):2906-22. · 4.47 Impact Factor
