Publications (235)519.13 Total impact
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Article: Rapid and multi-band variability of the TeV-bright active nucleus of the galaxy IC 310
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ABSTRACT: Context. The galaxy IC 310 has recently been identified as a $\gamma$-ray emitter by the Fermi-LAT and at very high energies by the MAGIC telescopes. Originally classified as a head-tail radio galaxy, the nature of this object is subject of controversy because its nucleus shows blazar-like behavior. Aims. In order to understand the nature of IC 310 and the origin of the VHE emission we studied the spectral and flux variability of IC 310 from the X-ray band to the VHE regime. Methods. The daily light curve of IC 310 above 300 GeV has been measured with MAGIC from 2009 October to 2010 February. Contemporaneous Fermi-LAT data (2008-2011) in the 10-500 GeV energy range were also analyzed. In X-ray, archival observations from 2003 to 2007 with XMM-Newton, Chandra, and Swift-XRT in the 0.5-10 keV band were studied. Results. Several flares with similar amplitude can be seen in the MAGIC light curve. Day to day flux variability is clearly present. The photon index between 120 GeV and 8 TeV is measured to be $\Gamma=2.0$ during both low and high flux states. It does not show variability, whereas the flux at 1 TeV changes by a factor of 7. Fermi-LAT detected only eight $\gamma$ rays in the energy range 10 GeV-500 GeV in three years of observation. The measured photon index of $\Gamma=1.3\pm0.5$ in the Fermi-LAT range is very hard. The X-ray measurements show strong variability in both flux and photon index. The latter varied from 1.76 to 2.55. Conclusion. The rapid variability measured in $\gamma$ rays and X-rays confirms the blazar-like behavior of the source. The spectral behavior measured in both energy bands suggest IC 310 could be linked to extreme HBL objects. The apparent luminosity of IC 310 is a few orders of magnitude lower than other extreme HBLs however and, atypical for an HBL, it harbors a kiloparsec-scale radio structure. Thus, IC 310 could be a peculiar type of a HBL.05/2013; -
Article: Androgen levels during adjuvant endocrine therapy in postmenopausal breast cancer patients.
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ABSTRACT: Abstract Objective To investigate plasma steroid hormone levels in postmenopausal breast cancer patients with and without adjuvant endocrine therapy and in healthy postmenopausal women. Methods Steroid hormone levels in postmenopausal breast cancer patients treated with aromatase inhibitors (n = 32) were compared with breast cancer patients treated with tamoxifen (n = 34), breast cancer patients without adjuvant endocrine therapy (n = 15), and healthy postmenopausal women (n = 56). Pregnenolone, 17-OH-pregnenolone, 17-OH-progesterone, 11- deoxycortisol, cortisol, cortisone, DHEA, androstenedione, total testosterone, dihydrotestosterone, estrone, and estradiol were measured using liquid chromatography tandem mass spectrometry. SHBG was measured by solid-phase chemiluminescent immunometric assays, and the free androgen index was calculated. Results Aromatase inhibitor users did not differ in dihydrotestosterone, total testosterone, androstenedione, DHEA, or free androgen index levels from healthy controls or untreated breast cancer patients. The highest total testosterone levels were found in tamoxifen-treated women, who had significantly higher plasma concentrations than both women treated with aromatase inhibitors, and breast cancer patients without adjuvant treatment. Concentrations of cortisol and cortisone were significantly greater in aromatase inhibitor users as well as tamoxifen users, in comparison with healthy controls and untreated breast cancer patients. Aromatase inhibitor users had lower estrone and estradiol plasma concentrations than all other groups. Conclusion Adjuvant treatment with aromatase inhibitors or tamoxifen was associated with increased cortisol and cortisone plasma concentrations as well as decreased estradiol concentrations. Androgen levels were elevated in tamoxifen treated women but not in aromatase inhibitor users.Climacteric 05/2013; · 1.99 Impact Factor -
Article: VHE gamma-ray emission from the FSRQs observed by the MAGIC telescopes
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ABSTRACT: Among more than fifty blazars detected in very high energy (VHE, E>100GeV) gamma-rays, only three belong to the subclass of Flat Spectrum Radio Quasars (FSRQs): PKS 1510-089, PKS 1222+216 and 3C 279. The detection of FSRQs in the VHE range is challenging, mainly because of their steep soft spectra in the GeV-TeV regime. MAGIC has observed and detected all FSRQs known to be VHE emitters up to now and found that they exhibit very different behavior. The 2010 discovery of PKS 1222+216 (z = 0.432) with the fast variability observed, challenges simple one-zone emission models and more complicated scenarios have been proposed. 3C 279 is the most distant VHE gamma-ray emitting AGN (z = 0.536), which was discovered by MAGIC in 2006 and detected again in 2007. In 2011 MAGIC observed 3C 279 two times: first during a monitoring campaign and later observations were triggered by a flare detected with Fermi-LAT. We present the MAGIC results and the multiwavelength behavior during this flaring epoch. Finally, we report the 2012 detection of PKS 1510-089 (z = 0.36), together with its simultaneous multiwavelength data from optical to gamma-rays.03/2013; -
Article: Discovery of very high energy gamma-ray emission from the blazar 1ES 1727+502 with the MAGIC Telescopes
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ABSTRACT: Motivated by the Costamante & Ghisellini (2002) predictions we investigated if the blazar 1ES 1727+502 (z=0.055) is emitting very high energy (VHE, E>100 GeV) gamma rays. We observed the BL Lac object 1ES 1727+502 in stereoscopic mode with the two MAGIC telescopes during 14 nights between May 6th and June 10th 2011, for a total effective observing time of 12.6 hours. For the study of the multiwavelength spectral energy distribution (SED) we use simultaneous optical R-band data from the KVA telescope, archival UV/optical and X-ray observations by instruments UVOT and XRT on board of the Swift satellite and high energy (HE, 0.1 GeV - 100 GeV) gamma-ray data from the Fermi-LAT instrument. We detect, for the first time, VHE gamma-ray emission from 1ES 1727+502 at a statistical significance of 5.5 sigma. The integral flux above 150 GeV is estimated to be (2.1\pm0.4)% of the Crab Nebula flux and the de-absorbed VHE spectrum has a photon index of (2.7\pm0.5). No significant short-term variability was found in any of the wavebands presented here. We model the SED using a one-zone synchrotron self-Compton model obtaining parameters typical for this class of sources.02/2013; -
Dataset: Albert etal 2008 MAGIC Observations of the Unidentified gamma-Ray Source TeV J2032+4130
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Article: Precursor flares in OJ 287
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ABSTRACT: We have studied three most recent precursor flares in the light curve of the blazar OJ 287 while invoking the presence of a precessing binary black hole in the system to explain the nature of these flares. Precursor flare timings from the historical light curves are compared with theoretical predictions from our model that incorporate effects of an accretion disk and post-Newtonian description for the binary black hole orbit. We find that the precursor flares coincide with the secondary black hole descending towards the accretion disk of the primary black hole from the observed side, with a mean z-component of approximately z_c = 4000 AU. We use this model of precursor flares to predict that precursor flare of similar nature should happen around 2020.96 before the next major outburst in 2022.12/2012; -
Article: The Simultaneous Low State Spectral Energy Distribution of 1ES 2344+514 from Radio to Very High Energies
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ABSTRACT: [Abridged] Context. To construct and interpret the spectral energy distribution (SED) of BL Lacertae objects, simultaneous broad-band observations are mandatory. Aims. We intend to study the simultaneous broad-band emission of the high-frequency peaked BL Lac object and known TeV emitter 1ES 2344+514 by means of a pre-organised multi-wavelength campaign independently of the current flux state. By correlating the obtained light curves and describing the corresponding SEDs with state-of-the-art models we intend to derive physical parameters of the emission region. Methods. The observations were conducted during simultaneous visibility windows of MAGIC and AGILE in late 2008. The measurements were complemented by Mets\"ahovi, RATAN-600, KVA+Tuorla, Swift and VLBA pointings. Additional coverage was provided by the ongoing long-term F-GAMMA and MOJAVE programs, the OVRO 40-m and CrAO telescopes as well as the Fermi satellite. The obtained SEDs are modelled using a one-zone as well as a self-consistent two-zone synchrotron self-Compton model. Results. 1ES 2344+514 is found at very low flux states in both X-rays and very high energy gamma rays. Variability is detected in the low frequency radio and X-ray bands only, where for the latter a small flare was observed. The X-ray flare was potentially caused by shock acceleration characterised by similar cooling and acceleration time scales. MOJAVE VLBA monitoring reveals a static jet whose components are stable over time scales of eleven years, opposite to previous findings. A significant correlation between the 15.0 GHz and the R-band monitoring light curves cannot be established. The observations presented here constitute the first multi-wavelength campaign on 1ES 2344+514 from radio to VHE energies and one of the few simultaneous SEDs during low activity states. The quasi-simultaneous Fermi-LAT data poses some challenges for SED modelling.11/2012; -
Article: Observations of the magnetars 4U 0142+61 and 1E 2259+586 with the MAGIC telescopes
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ABSTRACT: Magnetars are an extreme, highly magnetized class of isolated neutron stars whose large X-ray luminosity is believed to be driven by their high magnetic field. In this work we study for the first time the possible very high energy gamma-ray emission above 100 GeV from magnetars, observing the sources 4U 0142+61 and 1E 2259+586. We observed the two sources with atmospheric Cherenkov telescopes in the very high energy range (E > 100 GeV). 4U 0142+61 was observed with the MAGIC I telescope in 2008 for ~25 h and 1E 2259+586 was observed with the MAGIC stereoscopic system in 2010 for ~14 h. The data were analyzed with the standard MAGIC analysis software. Neither magnetar was detected. Upper limits to the differential and integral flux above 200 GeV were computed using the Rolke algorithm. We obtain integral upper limits to the flux of 1.52*10^-12cm^-2 s^-1 and 2.7*10^-12cm^-2 s^-1 with a confidence level of 95% for 4U 0142+61 and 1E 2259+586, respectively. The resulting differential upper limits are presented together with X-ray data and upper limits in the GeV energy range.11/2012; -
Article: Redshift constraints for RGB 0136+391 and PKS 0735+178 from deep optical imaging
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ABSTRACT: We present the results of deep I-band imaging of two BL Lacerate objects, RGB 0136+391 and PKS 0735+178, during an epoch when the optical nucleus was in a faint state in both targets. In PKS 0735+178 we find a significant excess over a point source, which, if fitted by the de Vaucouleurs model, corresponds to a galaxy with I = 18.64 +- 0.11 and r_eff = 1.8 +- 0.4 arcsec. Interpreting this galaxy as the host galaxy of PKS 0735+178 we derive z = 0.45 +- 0.06 using the host galaxy as a "standard candle". We also discuss the immediate optical environment of PKS 0735+178 and the identity of the MgII absorber at z = 0.424. Despite of the optimally chosen epoch and deep imaging we find the surface brightness profile of RGB 0136+391 to be consistent with a point source. By determining a lower limit for the host galaxy brightness by simulations, we derive z > 0.40 for this target.09/2012; -
Article: Variability of the blazar 4C 38.41 (B3 1633+382) from GHz frequencies to GeV energies
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ABSTRACT: The quasar-type blazar 4C 38.41 (B3 1633+382) experienced a large outburst in 2011, which was detected throughout the entire electromagnetic spectrum. We present the results of low-energy multifrequency monitoring by the GASP project of the WEBT consortium and collaborators, as well as those of spectropolarimetric/spectrophotometric monitoring at the Steward Observatory. We also analyse high-energy observations of the Swift and Fermi satellites. In the optical-UV band, several results indicate that there is a contribution from a QSO-like emission component, in addition to both variable and polarised jet emission. The unpolarised emission component is likely thermal radiation from the accretion disc that dilutes the jet polarisation. We estimate its brightness to be R(QSO) ~ 17.85 - 18 and derive the intrinsic jet polarisation degree. We find no clear correlation between the optical and radio light curves, while the correlation between the optical and \gamma-ray flux apparently fades in time, likely because of an increasing optical to \gamma-ray flux ratio. As suggested for other blazars, the long-term variability of 4C 38.41 can be interpreted in terms of an inhomogeneous bent jet, where different emitting regions can change their alignment with respect to the line of sight, leading to variations in the Doppler factor \delta. Under the hypothesis that in the period 2008-2011 all the \gamma-ray and optical variability on a one-week timescale were due to changes in \delta, this would range between ~ 7 and ~ 21. If the variability were caused by changes in the viewing angle \theta\ only, then \theta\ would go from ~ 2.6 degr to ~ 5 degr. Variations in the viewing angle would also account for the dependence of the polarisation degree on the source brightness in the framework of a shock-in-jet model.07/2012; -
Article: Multi-wavelength observations of blazar AO 0235+164 in the 2008-2009 flaring state
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ABSTRACT: The blazar AO 0235+164 (z = 0.94) has been one of the most active objects observed by Fermi Large Area Telescope (LAT) since its launch in Summer 2008. In addition to the continuous coverage by Fermi, contemporaneous observations were carried out from the radio to {\gamma} -ray bands between 2008 September and 2009 February. In this paper, we summarize the rich multi-wavelength data collected during the campaign (including F-GAMMA, GASP- WEBT, Kanata, OVRO, RXTE, SMARTS, Swift, and other instruments), examine the cross-correlation between the light curves measured in the different energy bands, and interpret the resulting spectral energy distributions in the context of well-known blazar emission models. We find that the {\gamma} -ray activity is well correlated with a series of near-IR/optical flares, accompanied by an increase in the optical polarization degree. On the other hand, the X-ray light curve shows a distinct 20 day high state of unusually soft spectrum, which does not match the extrapolation of the optical/UV synchrotron spectrum. We tentatively interpret this feature as the bulk Compton emission by cold electrons contained in the jet, which requires an accretion disk corona with an effective covering factor of 19% at a distance of 100 Rg . We model the broadband spectra with a leptonic model with external radiation dominated by the infrared emission from the dusty torus.07/2012; -
Article: MAGIC observations of the giant radio galaxy M87 in a low-emission state between 2005 and 2007
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ABSTRACT: We present the results of a long M87 monitoring campaign in very high energy $\gamma$-rays with the MAGIC-I Cherenkov telescope. We aim to model the persistent non-thermal jet emission by monitoring and characterizing the very high energy $\gamma$-ray emission of M87 during a low state. A total of 150\,h of data were taken between 2005 and 2007 with the single MAGIC-I telescope, out of which 128.6\,h survived the data quality selection. We also collected data in the X-ray and \textit{Fermi}--LAT bands from the literature (partially contemporaneous). No flaring activity was found during the campaign. The source was found to be in a persistent low-emission state, which was at a confidence level of $7\sigma$. We present the spectrum between 100\,GeV and 2\,TeV, which is consistent with a simple power law with a photon index $\Gamma=2.21\pm0.21$ and a flux normalization at 300\,GeV of $(7.7\pm1.3) \times 10^{-8}$ TeV$^{-1}$ s$^{-1}$ m$^{-2}$. The extrapolation of the MAGIC spectrum into the GeV energy range matches the previously published \textit{Fermi}--LAT spectrum well, covering a combined energy range of four orders of magnitude with the same spectral index. We model the broad band energy spectrum with a spine layer model, which can satisfactorily describe our data.07/2012; -
Article: High zenith angle observations of PKS 2155-304 with the MAGIC-I telescope
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ABSTRACT: The high frequency peaked BL Lac PKS 2155-304 with a redshift of z=0.116 was discovered in 1997 in the very high energy (VHE, E >100GeV) gamma-ray range by the University of Durham Mark VI gamma-ray Cherenkov telescope in Australia with a flux corresponding to 20% of the Crab Nebula flux. It was later observed and detected with high significance by the Southern Cherenkov observatory H.E.S.S. Detection from the Northern hemisphere is difficult due to challenging observation conditions under large zenith angles. In July 2006, the H.E.S.S. collaboration reported an extraordinary outburst of VHE gamma-emission. During the outburst, the VHE gamma-ray emission was found to be variable on the time scales of minutes and with a mean flux of ~7 times the flux observed from the Crab Nebula. Follow-up observations with the MAGIC-I standalone Cherenkov telescope were triggered by this extraordinary outburst and PKS 2155-304 was observed between 28 July to 2 August 2006 for 15 hours at large zenith angles. Here we present our studies on the behavior of the source after its extraordinary flare and an enhanced analysis method for data taken at high zenith angles. We developed improved methods for event selection that led to a better background suppression. The averaged energy spectrum we derived has a spectral index of -3.5 +/- 0.2 above 400GeV, which is in good agreement with the spectral shape measured by H.E.S.S. during the major flare on MJD 53944. Furthermore, we present the spectral energy distribution modeling of PKS 2155-304. With our observations we increased the duty cycle of the source extending the light curve derived by H.E.S.S. after the outburst. Finally, we find night-by-night variability with a maximal amplitude of a factor three to four and an intranight variability in one of the nights (MJD 53945) with a similar amplitude.07/2012; -
Article: The structure and emission model of the relativistic jet in the quasar 3C 279 inferred from radio to high-energy gamma-ray observations in 2008-2010
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ABSTRACT: We present time-resolved broad-band observations of the quasar 3C 279 obtained from multi-wavelength campaigns conducted during the first two years of the Fermi Gamma-ray Space Telescope mission. While investigating the previously reported gamma-ray/optical flare accompanied by a change in optical polarization, we found that the optical emission appears delayed with respect to the gamma-ray emission by about 10 days. X-ray observations reveal a pair of `isolated' flares separated by ~90 days, with only weak gamma-ray/optical counterparts. The spectral structure measured by Spitzer reveals a synchrotron component peaking in the mid-infrared band with a sharp break at the far-infrared band during the gamma-ray flare, while the peak appears in the mm/sub-mm band in the low state. Selected spectral energy distributions are fitted with leptonic models including Comptonization of external radiation produced in a dusty torus or the broad-line region. Adopting the interpretation of the polarization swing involving propagation of the emitting region along a curved trajectory, we can explain the evolution of the broad-band spectra during the gamma-ray flaring event by a shift of its location from ~ 1 pc to ~ 4 pc from the central black hole. On the other hand, if the gamma-ray flare is generated instead at sub-pc distance from the central black hole, the far-infrared break can be explained by synchrotron self-absorption. We also model the low spectral state, dominated by the mm/sub-mm peaking synchrotron component, and suggest that the corresponding inverse-Compton component explains the steady X-ray emission.06/2012; -
Article: Constraining Cosmic Rays and Magnetic Fields in the Perseus Galaxy Cluster with TeV observations by the MAGIC telescopes
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ABSTRACT: Galaxy clusters are being assembled today in the most energetic phase of hierarchical structure formation which manifests itself in powerful shocks that contribute to a substantial energy density of cosmic rays (CRs). Hence, clusters are expected to be luminous gamma-ray emitters since they also act as energy reservoirs for additional CR sources, such as active galactic nuclei and supernova-driven galactic winds. To detect the gamma-ray emission from CR interactions with the ambient cluster gas, we conducted the deepest to date observational campaign targeting a galaxy cluster at very high-energy gamma-rays and observed the Perseus cluster with the MAGIC Cherenkov telescopes for a total of ∼ 85 h of effective observing time. This campaign resulted in the detection of the central radio galaxy NGC 1275 at energies E > 100 GeV with a very steep energy spectrum. Here, we restrict our analysis to energies E > 630 GeV and detect no significant gamma-ray excess. This constrains the average CR-to-thermal pressure ratio to be 1–2%, depending on assumptions and the model for CR emission. Comparing these gamma-ray upper limits to models inferred from cosmological cluster simulations that include CRs constrains the maximum CR acceleration efficiency at structure formation shocks to be < 50%. Alternatively, this may argue for non-negligible CR transport processes such as CR streaming and diffusion into the outer cluster regions. Finally, we derive lower limits on the magnetic field distribution assuming that the Perseus radio mini-halo is generated by secondary electrons/positrons that are created in hadronic CR interactions: assuming a spectrum of E −2.2 around TeV energies as implied by cluster simulations, we limit the central magnetic field to be > 4–9 µG, depending on the rate of decline of the magnetic field strength toward larger radii. This range is well below field strengths inferred from Faraday rotation measurements in cool cores. Hence, the hadronic model remains a plausible explanation of the Perseus radio mini-halo.04/2012; 2517(13). -
Article: Discovery of VHE gamma-rays from the blazar 1ES 1215+ 303 with the MAGIC Telescopes and simultaneous multi-wavelength observations
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ABSTRACT: Context. We present the discovery of very high energy (VHE, E > 100 GeV) γ-ray emission from the BL Lac object 1ES 1215+303 by the MAGIC telescopes and simultaneous multi-wavelength data in a broad energy range from radio to γ-rays. Aims. We study the VHE γ-ray emission from 1ES 1215+303 and its relation to the emissions in other wavelengths. Methods. Triggered by an optical outburst, MAGIC observed the source in January-February 2011 for 20.3 hrs. The target was monitored in the optical R-band by the KVA telescope that also performed optical polarization measurements. We triggered target of opportunity observations with the Swift satellite and obtained simultaneous and quasi-simultaneous data from the Fermi Large Area Telescope and from the Metsähovi radio telescope. We also present the analysis of older MAGIC data taken in 2010. Results. The MAGIC observations of 1ES 1215+303 carried out in January-February 2011 resulted in the first detection of the source at VHE with a statistical significance of 9.4 σ. Simultaneously, the source was observed in a high optical and X-ray state. In 2010 the source was observed in a lower state in optical, X-ray, and VHE, while the GeV γ-ray flux and the radio flux were comparable in 2010 and 2011. The spectral energy distribution obtained with the 2011 data can be modeled with a simple one zone SSC model, but it requires extreme values for the Doppler factor or the electron energy distribution.R. Zanin. 04/2012; 2616323536(33). -
Article: Detection of VHE \gamma-rays from HESS J0632+057 during the 2011 February X-ray outburst with the MAGIC Telescopes
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ABSTRACT: The very high energy (VHE) \gamma-ray source HESS J0632+057 has recently been confirmed to be a \gamma-ray binary. The optical counterpart is the Be star MWC 148, and a compact object of unknown nature orbits it every ~321 d with a high eccentricity of ~0.8. We monitored HESS J0632+057 with the stereoscopic MAGIC telescopes from 2010 October to 2011 March and detected significant VHE \gamma-ray emission during 2011 February, when the system exhibited an X-ray outburst. We find no \gamma-ray signal in the other observation periods when the system did not show increased X-ray flux. Thus HESS J0632+057 exhibits \gamma-ray variability on timescales of the order of one to two months possibly linked to the X-ray outburst that takes place about 100 days after the periastron passage. Furthermore our measurements provide for the first time the \gamma-ray spectrum down to about 140 GeV and indicate no turnover of the spectrum at low energies. We compare the properties of HESS J0632+057 with the similar \gamma-ray binary LS I +61 303, and discuss on the possible origin of the multi-wavelength emission of the source03/2012; -
Article: Discovery of VHE gamma-rays from the blazar 1ES 1215+303 with the MAGIC Telescopes and simultaneous multi-wavelength observations
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ABSTRACT: Context. We present the discovery of very high energy (VHE, E > 100GeV) gamma-ray emission from the BL Lac object 1ES 1215+303 by the MAGIC telescopes and simultaneous multi-wavelength data in a broad energy range from radio to gamma-rays. Aims. We study the VHE gamma-ray emission from 1ES 1215+303 and its relation to the emissions in other wavelengths. Methods. Triggered by an optical outburst, MAGIC observed the source in January-February 2011 for 20.3 hrs. The target was monitored in the optical R-band by the KVA telescope that also performed optical polarization measurements. We triggered target of opportunity observations with the Swift satellite and obtained simultaneous and quasi-simultaneous data from the Fermi Large Area Telescope and from the Mets\"ahovi radio telescope. We also present the analysis of older MAGIC data taken in 2010. Results. The MAGIC observations of 1ES 1215+303 carried out in January-February 2011 resulted in the first detection of the source at VHE with a statistical significance of 9.4 sigma. Simultaneously, the source was observed in a high optical and X-ray state. In 2010 the source was observed in a lower state in optical, X-ray, and VHE, while the GeV gamma-ray flux and the radio flux were comparable in 2010 and 2011. The spectral energy distribution obtained with the 2011 data can be modeled with a simple one zone SSC model, but it requires extreme values for the Doppler factor or the electron energy distribution.03/2012; -
Article: Higher than expected estradiol levels in aromatase inhibitor-treated, postmenopausal breast cancer patients.
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ABSTRACT: ABSTRACT Objective Vaginal estradiol is considered contraindicated in aromatase inhibitor (AI)-treated patients because of the risk of elevated estrogen levels. This leaves limited treatment options for patients experiencing gynecological symptoms. However, in clinical practice, no precise estimation has been performed of circulating estrogens and aromatase index in postmenopausal breast cancer patients on long-lasting AI or tamoxifen treatment. Methods Steroid hormones were measured using liquid chromatography tandem mass spectrometry (LC-MS/MS) and extraction radioimmunoassay (RIA). Postmenopausal AI-treated patients (n =33) were compared with tamoxifen-treated patients (n =34) and controls without vaginal treatment (n =56), with vaginal estradiol (n =25), or with estriol (n =11) treatment. Results By use of LC-MS/MS, median (range) estradiol plasma concentrations were 16.7 (2.4-162.6), 31.0 (13.4-77.1), 27.2 (7.8-115.8) and 33.3 (20.3-340.1) pmol/l in AI-treated breast cancer patients, tamoxifen-treated breast cancer patients, postmenopausal controls and postmenopausal controls on vaginal estradiol, respectively. The AI-treated group and subgroups had significantly lower estradiol and estrone concentrations than all other groups (p <0.05). There was extensive interindividual variation in estradiol concentration within the AI-treated group, measured using both LC-MS/MS (2.3-182.0 pmol/l) and extraction RIA (2.4-162.6 pmol/l). The AI-treated group had lower aromatase index compared to all other groups (p <0.05-0.001). Conclusion Circulating estrogen levels may have been underestimated in previous longitudinal studies of AI-treated breast cancer patients. Additional studies are required to further evaluate the role of circulating estrogens in breast cancer patients suffering from gynecological symptoms.Climacteric 02/2012; 15(5):473-80. · 1.99 Impact Factor -
Article: The 2010 Very High Energy γ-Ray Flare and 10 Years of Multi-wavelength Observations of M 87
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ABSTRACT: The giant radio galaxy M 87 with its proximity (16 Mpc), famous jet, and very massive black hole ((3 – 6) × 109 M ☉) provides a unique opportunity to investigate the origin of very high energy (VHE; E > 100 GeV) γ-ray emission generated in relativistic outflows and the surroundings of supermassive black holes. M 87 has been established as a VHE γ-ray emitter since 2006. The VHE γ-ray emission displays strong variability on timescales as short as a day. In this paper, results from a joint VHE monitoring campaign on M 87 by the MAGIC and VERITAS instruments in 2010 are reported. During the campaign, a flare at VHE was detected triggering further observations at VHE (H.E.S.S.), X-rays (Chandra), and radio (43 GHz Very Long Baseline Array, VLBA). The excellent sampling of the VHE γ-ray light curve enables one to derive a precise temporal characterization of the flare: the single, isolated flare is well described by a two-sided exponential function with significantly different flux rise and decay times of τrise d = (1.69 ± 0.30) days and τdecay d = (0.611 ± 0.080) days, respectively. While the overall variability pattern of the 2010 flare appears somewhat different from that of previous VHE flares in 2005 and 2008, they share very similar timescales (~day), peak fluxes (Φ>0.35 TeV (1-3) × 10–11 photons cm–2 s–1), and VHE spectra. VLBA radio observations of 43 GHz of the inner jet regions indicate no enhanced flux in 2010 in contrast to observations in 2008, where an increase of the radio flux of the innermost core regions coincided with a VHE flare. On the other hand, Chandra X-ray observations taken ~3 days after the peak of the VHE γ-ray emission reveal an enhanced flux from the core (flux increased by factor ~2; variability timescale <2 days). The long-term (2001-2010) multi-wavelength (MWL) light curve of M 87, spanning from radio to VHE and including data from Hubble Space Telescope, Liverpool Telescope, Very Large Array, and European VLBI Network, is used to further investigate the origin of the VHE γ-ray emission. No unique, common MWL signature of the three VHE flares has been identified. In the outer kiloparsec jet region, in particular in HST-1, no enhanced MWL activity was detected in 2008 and 2010, disfavoring it as the origin of the VHE flares during these years. Shortly after two of the three flares (2008 and 2010), the X-ray core was observed to be at a higher flux level than its characteristic range (determined from more than 60 monitoring observations: 2002-2009). In 2005, the strong flux dominance of HST-1 could have suppressed the detection of such a feature. Published models for VHE γ-ray emission from M 87 are reviewed in the light of the new data.The Astrophysical Journal 02/2012; 746(2):151. · 6.02 Impact Factor
Top co-authors
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Institutions
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2012
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Uppsala University
- Department of Women's and Children's Health
Uppsala, Uppsala, Sweden
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1996–2011
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University of Turku
- Department of Physics and Astronomy
Turku, Western Finland, Finland
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2009
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Harvard-Smithsonian Center for Astrophysics
Cambridge, MA, USA
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2006–2007
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Universität Würzburg
- Faculty of Physics and Astronomy
Würzburg, Bavaria, Germany
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