Publications (2)23.36 Total impact
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Article: Total syntheses of the elusive welwitindolinones with bicyclo[4.3.1] cores.
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ABSTRACT: The welwitindolinones with bicyclo[4.3.1] cores are a class of natural products that have attracted tremendous interest from the synthetic community because of their fascinating structures and promising biological profiles. More than 15 research groups worldwide have reported progress toward these elusive natural products. This Minireview describes contemporary studies aimed at the total synthesis of these challenging targets, in addition to the two recently completed syntheses of welwitindolinones with bicyclo[4.3.1] cores reported by Rawal and Garg in 2011. Both of the completed efforts rely on C4-C11 bond constructions to access the congested bicyclic framework of these elusive natural products.Angewandte Chemie International Edition 03/2012; 51(16):3758-65. · 13.45 Impact Factor -
Article: Total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate.
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ABSTRACT: We report the first total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate. Our route features a number of key transformations, including an indolyne cyclization to assemble the [4.3.1]-bicyclic scaffold, as well as a late-stage intramolecular nitrene insertion to functionalize the C11 bridgehead carbon en route to the natural product.Journal of the American Chemical Society 08/2011; 133(40):15797-9. · 9.91 Impact Factor
