Eun Jung Lee

Yonsei University Hospital, Sŏul, Seoul, South Korea

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Publications (160)454.14 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: Klebsiella pneumoniae is an uncommon cause of community-acquired bacterial meningitis. The clinical and laboratory characteristics of community-acquired K. pneumoniae meningitis (CA-KPM) remain to be elucidated. In this study, we compared the clinical and laboratory features, and outcomes, of CA-KPM with those of community-acquired Streptococcus pneumoniae meningitis (CA-SPM). Methods: This multi-center, retrospective cohort study was performed at 8 general hospitals in the Republic of Korea. Using a clinical microbiology computerized database, all patients whose cerebrospinal fluid (CSF) cultures yielded K. pneumoniae or S. pneumoniae between January 1997 and March 2013 were identified. Adult patients with clinical meningitis were identified by detailed review of medical records. Results: A total of 83 patients, 27 with CA-KPM and 56 with CA-SPM, were included. The proportion of males (KPM, 55.6% vs. SPM, 55.4%, P = 0.99) and median age (KPM, 59 year vs. 59 year, P = 0.23) were not significantly different between the groups. Diabetes mellitus (KPM, 48.1% vs. SPM, 21.4%; P = 0.01) and liver cirrhosis (KPM, 22.2% vs. SPM, 5.4%; P = 0.05) were more common in the CA-KPM group. Although the profiles of CSF analyses did not differ significantly between the groups, comatose mentality was more frequent in the CA-KPM group (KPM, 40.7% vs. SPM, 12.5%; P = 0.01). Septic shock (KPM, 44.4% vs. SPM, 89%; P < 0.001) and concomitant extrameningeal infection were also more common in the CA-KPM group (KPM, 37% vs. SPM, 7.1%; P = 0.001). Vancomycin plus cefotaxime/ceftriaxone was the most frequently used initial empirical therapy (KPM, 74.1% vs. SPM, 85.7%; P = 0.23) in both groups. However, 28-day mortality (KPM, 44.4% vs. SPM, 10.7%; P < 0.001) and in-hospital mortality (KPM, 51.9% vs. SPM, 14.3%; P < 0.001) were higher in the CA-KPM group. Conclusion: Diabetes mellitus and liver cirrhosis are more common in K. pneumoniae meningitis than S. pneumoniae meningitis, and the former is more likely to present severe manifestations and poor outcomes.
    IDWeek 2014 Meeting of the Infectious Diseases Society of America; 10/2014
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    ABSTRACT: “Proteinticle” is nano-scale protein particle that is self-assembled inside cells with constant 3D structure and surface topology. The binding of IgG to B domain of Staphylococcal protein A (SPAB) molecules that are genetically inserted into the surface of proteinticle enables the variable domains of bound IgG to be well oriented to effectively capture antigens, accordingly forming a highly sensitive 3D IgG probe. The five different proteinticles that originate from human, bacteria, and virus and totally differ in size, shape, and surface structure were used for the surface display of SPAB. The dissociation constant (KD) in the binding of IgG to SPAB on the proteinticle surface was estimated based on Langmuir adsorption isotherm model: KD was 1-3 orders-of-magnitude lower compared to the previously reported KD in the binding of IgG to Staphylococcal protein A. The surface density and distribution of SPAB and especially the existence of hot (or highly congested) spots of SPAB, which depend on surface structure and number of subunits as well as size and shape of proteinticle, is of crucial importance for the effective binding of IgG to SPAB on proteinticles. Although the five different proteinticles were demonstrated as proof-of-concept here, SPAB-mediated immobilization of IgG on the other proteinticles would be very useful for the fabrication of sensitive 3D immunoassay platforms.
    Nanoscale 10/2014; · 6.73 Impact Factor
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    ABSTRACT: Non-destructive continuous monitoring of regenerative tissue is required throughout the entire periodof in vitro tissue culture. Microscopic electrical impedance tomography (micro-EIT) has the potentialto monitor the physiological state of tissues by forming three-dimensional images of impedancechanges in a non-destructive and label-free manner. We developed a new micro-EIT system andreport on simulation and experimental results of its macroscopic model.
    BioMedical Engineering OnLine 10/2014; 13(1):142. · 1.61 Impact Factor
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    ABSTRACT: Retinal ganglion cell (RGC) axons of binocular animals cross the midline at the optic chiasm (OC) to grow toward their synaptic targets in the contralateral brain. Ventral anterior homeobox 1 (Vax1) plays an essential role in the development of the OC by regulating RGC axon growth in a non-cell autonomous manner. Here, we identify an unexpected function of Vax1 that is secreted from ventral hypothalamic cells and diffuses to RGC axons, where it promotes axonal growth independent of its transcription factor activity. We demonstrate that Vax1 binds to extracellular sugar groups of the heparan sulfate proteoglycans (HSPGs) located in RGC axons. Both Vax1 binding to HSPGs and subsequent penetration into the axoplasm, where Vax1 activates local protein synthesis, are required for RGC axonal growth. Together, our findings demonstrate that Vax1 possesses a novel RGC axon growth factor activity that is critical for the development of the mammalian binocular visual system.
    eLife. 09/2014;
  • 08/2014;
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    ABSTRACT: PGCS-NPs (40 nm) with excellent photo-thermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.
    Advanced Materials 07/2014; · 14.83 Impact Factor
  • Jin Sung Kim, Yong Joo Yoon, Eun Jung Lee
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    ABSTRACT: Abstract Conclusion: Antimicrobial agents (AMAs) and mast cells in chronic otitis media (COM) may play a protective role in the pathogenesis of COM. Among them, our results indicated that lysozyme may be the most important parameter of the mucosa infectivity in COM. Objectives: AMAs include alpha 1-antitrypsin (α1-AT), lysozyme, and lactoferrin and exhibit innate immune activity that is known to play a critical role in mucosal defenses. In addition, proteases expressed in mast cells contribute to mucosal defenses. The aim of this study was to identify AMAs responsible for COM as well as their association with middle ear mucosal diseases. Methods: Middle ear mucosa (MEM) was intraoperatively collected by biopsy from patients, diagnosed as COM without or with cholesteatoma, and immediately processed for immunohistochemical study to evaluate expression of AMAs and mast cell proteases (chymase and tryptase). Results: The AMAs and mast cell enzymes were observed prominently in the chronic middle ear diseases whereas immunoreactivity of α1-AT and lysozyme was not significantly increased in the COM with cholesteatoma compared with that in COM without cholesteatoma. Lactoferrin was not detected in the diseased MEMs.
    Acta oto-laryngologica. 06/2014;
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    ABSTRACT: Lipofibromatous hamartomas (LFHs) are rare benign tumors that typically present as slow-growing firm masses in the subcutaneous soft tissue of the extremities. These often develop in young adults on the volar aspects of the hands, wrists, and forearms along major nerves and their branches. Only a single case of LFH growth along a cranial nerve has been reported.A 41-year-old man presented with a subcutaneous soft mass of the cheek. Histologically, the mass consisted of a proliferating fibrofatty tissue that surrounded and infiltrated the nerve structure and it was confirmed to be an LFH. After surgical excision, the patient experienced mild facial numbness and motor disturbance on the side ipsilateral to the resection. Because complete excision of the mass can cause sensory or motor disturbances, an accurate diagnosis and proper subsequent treatment, such as partial decompression, are necessary.
    Journal of Craniofacial Surgery 06/2014; 25(4):1553-1554. · 0.69 Impact Factor
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    ABSTRACT: Abstract Background: Recently, robot-assisted neck dissection (ND) using a transaxillary approach in thyroid cancer patients with lateral neck metastases (LNM) was demonstrated to be feasible. The aim of this study was to compare the surgical outcomes of a modified transaxillary and retroauricular (TARA) versus a conventional transcervical approach in papillary thyroid carcinoma (PTC) patients with LNM. Patients and Methods: In total, 47 patients with PTC underwent total thyroidectomy with central compartment ND and modified radical ND except Level I. Twenty-two NDs were performed via the TARA approach, and 25 unilateral NDs were performed via the conventional transcervical approach. Results: The TARA and the open ND groups consisted of 22 and 25 patients, respectively. The operation time for ND in the TARA group was longer than that in the open ND group (209.4±38.2 minutes versus 143.1±30.5 minutes; P=.000). The mean scar satisfaction score in the TARA group was higher than in the conventional ND group (3.9±1.0 versus 2.8±1.0; P=.000). There were no differences in the mean number of retrieved lymph nodes. Conclusions: The robot-assisted ND via the TARA approach can be an alternative option that produces excellent esthetic results for the management of LNM in PTC patients.
    Journal of Laparoendoscopic & Advanced Surgical Techniques 04/2014; · 1.07 Impact Factor
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    ABSTRACT: Seborrheic keratosis (SK) is common benign epithelial tumor of the skin that can be associated with other cutaneous tumors such as basal cell carcinoma, squamous cell carcinoma and melanoma. On the other hand, melanocytic nevus (MN) is another very common disease, showing anecdotal association with other cutaneous tumors such as trichoepithelioma, syringoma, basal cell carcinoma, trichilemmal cyst and epidermoid cyst. Although it has recently been reported that somatic mutation of BRAF gene is implicated in MN quite frequently, their pathogenic mechanisms, especially the association with other cutaneous tumors, are still elusive. Despite the high frequency of both tumors, however, collision tumors of SK and MN are extremely rare that only a few case reports have been documented so far. Hereby, we report five cases of simultaneous occurrence of SK and MN in 14-year-old female, 36-year-old female, 39-year-old female, 58-year-old male, and 62-year-old male patients. Additional molecular tests for BRAF mutation (V600E) on micro-dissected tissue of the 58-year-old man revealed positivity on the MN and negativity on the SK. Although these results cannot give direct evidence that both tumors have different pathogenic mechanisms, it seems to be more relevant that these collision tumors may occur by chance. Introduction Seborrheic keratosis (SK) is one of the most common benign epithelial tumors of the skin. Despite its frequency, many aspects of SK, especially its pathogenetic mechanism, remain elusive. Not a small number of cutaneous malignant tumors such as basal cell carcinoma, squamous cell carcinoma and melanoma have been documented to be found with SK [1]. Benign tumors that have very occasionally been documented include cutaneous ganglioneuroma, sebaceoma, eccrine poroma and trichilemmoma [1]. However, whether these combined tumors and SK share the same pathogenic mechanism is unclear. Likewise, melanocytic nevus (MN) is another very common disease, showing anecdotal association with other cutaneous tumors such as trichoepithelioma, syringoma, basal cell carcinoma, trichilemmal cyst and epidermoid cyst [1]. Although it has recently been reported that somatic mutation of BRAF gene is implicated in MN quite frequently, their pathogenic mechanisms, especially the association with other cutaneous tumors, are still elusive [2]. Considering the frequency of these two tumors, there have been surprisingly few additional reports of the cases in the literature that SK and MN are combined in the same lesion [3-9]. Some of the cases even showed additional concurrent occurrence of other tumors such as basal cell carcinoma, which suggests the hypothesis that multipotential differentiation capacity of the follicular germ may explain the coexistence of these tumors [6,8].
    Our Dermatology Journal. 04/2014; 5(2):179-182.
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    ABSTRACT: Ginseng is one of the most important folk medicines in the East Asian countries. Ginseng has various bioactive effects on human health including its potential activity of improving the glucose homeostasis and insulin sensitivity. To test the efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats. Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract enriched with ginsenosides was used as experimental material. Streptozotocin-induced diabetic 'Sprague Dawley' male rats were used as experimental systems and were fed with Tissue culture raised mountain ginseng adventitious root extract. Field cultivated Korean ginseng root extract fed rats were used as positive control and several indices such as body weight, blood glucose level and other serological indicators were tested. Chemical profile showed TCMGARs were rich in varied ginsenosides especially Rb1, Rb2, Rc, Rd, Rg3, and Rh2 when compared to filed cultivated Korean ginseng. TCMGARs extract at dosage levels of 250 and 500mg/kg body weight significantly lowered the blood glucose, total cholesterol and triglyceride content in streptozotocin-induced diabetic rats. The data of in vivo experiments on anti-glycemic effects of TCMGARs proves their efficacy and also their use as dietary supplement.
    Journal of ethnopharmacology 04/2014; · 2.32 Impact Factor
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    ABSTRACT: The Warthin-like variant of papillary thyroid carcinoma (WL-PTC) was first introduced by Apel et al. 1 in 1995 as an extremely rare subtype of papillary thyroid carcinoma (PTC) that is charac-terized by papillary architecture, lined by Hürthle cells, with classical cytologic features of PTC cells, and a heavy lymphocytic stroma of the papillary core. WL-PTC is now classified in the World Health Organization terminology as a special subtype of an oncocytic variant of PTC...
    The Korean Journal of Pathology 04/2014; 48(2):170-3. · 0.17 Impact Factor
  • The Korean Journal of Pathology 04/2014; 48(2):162-3. · 0.17 Impact Factor
  • Yeon Sup Yoon, Yong Joo Yoon, Eun Jung Lee
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    ABSTRACT: Osteomas of the middle ear are rare benign neoplasms. To date, only a few cases have been reported. Osteomas of the middle ear are small, single, usually unilateral, peduncular growths, off-white in color, with a smooth or multilobular surface, asymptomatic or causing functional disorders. The most common symptom is conductive hearing loss because of impingement of the ossicular chain. Some cases are asymptomatic and are diagnosed incidentally. We present two cases of incidentally detected middle ear osteoma. Based on a review of the main articles in the literature and analysis of two cases managed in our department, we describe the clinical spectrum, etiology, and management of middle ear osteomas.
    American journal of otolaryngology 03/2014; · 0.77 Impact Factor
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    ABSTRACT: In the present study, we aimed to investigate anti-obesity effect of CAPE in vivo, and the mechanism by which CAPE regulates body weight in vitro. To confirm anti-obesity effect of CAPE in vivo, mice were fed with a high fat diet (HFD) with different concentrations of CAPE for 5 weeks. CAPE significantly reduced body weight gain and epididymal fat mass in obese mice fed a HFD. In accordance with in vivo results, Oil red O staining results showed that CAPE significantly suppressed MDI-induced adipogenesis of 3T3-L1 preadipocytes. FACS analysis results showed that CAPE delayed MDI-stimulated cell cycle progression, thereby contributing to inhibit mitotic clonal expansion (MCE) which is prerequisite step for adipogenesis. Also, CAPE regulated expression of cyclin D1 and phosphorylation of ERK and Akt which are upstream of cyclin D1. These results suggest that CAPE exerts anti-obesity effect in vivo, presumably through inhibiting adipogenesis at early stage of adipogenesis.
    Journal of Agricultural and Food Chemistry 03/2014; · 3.11 Impact Factor
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    ABSTRACT: Thymidine phosphorylase (TP), a key enzyme in the pyrimidine nucleoside salvage pathway, catalyses the reversible phosphorylation of thymidine, thereby generating thymine and 2-deoxy-D-ribose-1-phosphate. By regulating the levels of endogenous thymidine, TP may influence [(18)F]fluorothymidine ([(18)F]FLT) uptake. We investigated the effect of TP activity on [(18)F]FLT uptake by tumours. Uptake of [(3)H]FLT and [(3)H]thymidine ([(3)H]Thd) and the activities of TP, thymidine kinase 1 (TK1), and equilibrative nucleoside transporter 1 (ENT1) were determined in exponentially growing A431, A549, HT29, HOP92, ACHN, and SKOV3 cells in the presence or absence of tipiracil hydrochloride, a TP inhibitor. Eighty-five non-small cell lung cancer tissues from a patient cohort that was previously studied with [(18)F]FLT positron emission tomography (PET) were retrieved and subjected to immunohistochemical analysis of TP expression. Factors that affected the maximum standardised uptake value (SUVmax) of [(18)F]FLT-PET were identified by multiple linear regression analysis. A431 cells had the highest TP activity; A549 and HT29 cells had moderate TP activity; and ACHN, SKOV3, and HOP92 cells had little detectable TP activity. Cell lines with high TP activity took up more [(3)H]FLT than [(3)H]Thd, whereas cells with little TP activity took up more [(3)H]Thd than [(3)H]FLT. In cells with high TP activity, TP inhibition decreased [(3)H]FLT uptake and increased [(3)H]Thd uptake. However, TP inhibition had no effect on ACHN, SKOV3, and HOP92 cells. TP inhibition did not change TK1 or ENT1 activity, but did increase the intracellular level of thymidine. The SUVmax of [(18)F]FLT was affected by three independent factors: Ki-67 expression (P < 0.001), immunohistochemical TP score (P < 0.001), and tumour size (P = 0.015). TP activity influences [(18)F]FLT uptake, and may explain preferential uptake of [(18)F]FLT over [(3)H]Thd. These results provide important insights into the biology of [(18)F]FLT as a proliferation marker.
    European Journal of Nuclear Medicine 02/2014; · 4.53 Impact Factor
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    ABSTRACT: A 39-year-old man presented with left shoulder and interscapular pain. Tc-MDP bone scan demonstrated multiple active bone lesions including scapula, spines, ribs, and pelvis. Chest X-ray showed no active lung lesion, and MRI demonstrated infiltrative enhancing lesions in the T-spines and ribs, indicating skeletal metastasis. F-FDG PET/CT performed to search for hidden malignancy revealed multiple osteolytic lesions with intense FDG uptake, supporting metastasis. Tissue obtained from the T1 lesion showed no malignant cells but was positive for Mycobacterium tuberculosis. After 18 months of antituberculosis medication, follow-up F-FDG PET/CT showed complete normalization of FDG uptake in the skeletal lesions.
    Clinical nuclear medicine 02/2014; · 3.92 Impact Factor
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    ABSTRACT: Two different protein nanoparticles that are totally different in shape and surface structure, i.e. Escherichia coli DNA-binding protein (eDPS) (spherical, 10 nm) and Thermoplasma acidophilum proteasome (tPTS) (cylindrical, 12 × 15 nm) were engineered for in vivo optical tumor detection: arginine–glycine–aspartic acid (RGD) peptide (CDCRGDCFC) was genetically inserted to the surface of each protein nanoparticle, and also near-infrared fluorescence dye was chemically linked to the surface lysine residues. The specific affinity of RGD for integrin (αvβ3) facilitated the uptake of RGD-presenting protein nanoparticles by integrin-expressing tumor cells, and also the protein nanoparticles neither adversely affected cell viability nor induced cell damage. After intravenously injected to tumor-bearing mice, all the protein nanoparticles successfully reached tumor with negligible renal clearance, and then the surface RGD peptides caused more prolonged retention of protein nanoparticles in tumor and accordingly higher fluorescence intensity of tumor image. In particular, the fluorescence of tumor image was more intensive with tPTS than eDPS, which is due presumably to longer in vivo half-life and circulation of tPTS that originates from thermophilic and acidophilic bacterium. Although eDPS and tPTS were used as proof-of-concept in this study, it seems that other protein nanoparticles with different size, shape, and surface structure can be applied to effective in vivo tumor detection.
    Biomaterials 01/2014; 35(24):6422–6429. · 8.31 Impact Factor
  • Eun Jung Lee, Yong Joo Yoon
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    ABSTRACT: To report the case of a healthy man with a previously unreported combination of generalized varicelliform eruption and herpes zoster oticus. A 44-year-old immunocompetent man who developed generalized varicelliform eruption after peripheral facial palsy with herpes zoster oticus without any underlying immunocompromised state. The skin lesion was improved during his hospitalization period. Facial palsy was completely cured after 2 months of treatment. Herpes zoster oticus occurs rarely and accounts for approximately 1% of all cases of herpes zoster and generalized varicelliform eruption occurs in 2% to 10% of unselected patients with herpes zoster. Most of these patients have an underlying condition that is associated with an immunocompromised state such as lymphoproliferative disease. Varicelliform eruptions are extremely rare among healthy patients without any underlying disease.
    Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 01/2014; 35(1):e57-e59. · 1.44 Impact Factor
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    ABSTRACT: Malignant schwannoma is an extremely rare tumor and the risk of malignant schwannoma increases in patients with von Recklinghausen's disease. Recently, we encountered a case of solitary malignant schwannoma in the choana and posterior nasal septum. Malignant schwannoma has not been previously reported in these locations. A 53-year-old man, who was immunologically healthy and showed no abnormal dermatological lesions, presented with a polypoid mass in the right nasal cavity and underwent endoscopic mass excision. The mass originated from the choana and the posterior portion of the right nasal septum. This mass was confirmed as a malignant schwannoma on histological examination and immunohistochemical staining. After endoscopic excision, postoperative adjuvant radiotherapy was administered, and there was no recurrence at 1 year after treatment. This case suggests that a solitary malignant schwannoma should be considered in the differential diagnosis of a mass in the posterior nasal cavity.
    Case reports in otolaryngology. 01/2014; 2014:202910.

Publication Stats

1k Citations
454.14 Total Impact Points

Institutions

  • 2014
    • Yonsei University Hospital
      Sŏul, Seoul, South Korea
  • 2012–2014
    • Chungbuk National University
      • Research Center for the Development of Advanced Horticultural Technology
      Chinsen, North Chungcheong, South Korea
  • 2011–2014
    • Korea Advanced Institute of Science and Technology
      • Department of Biological Sciences
      Sŏul, Seoul, South Korea
    • Korea Food Research Institute
      Sŏul, Seoul, South Korea
    • Konkuk University Medical Center
      Changnyeong, South Gyeongsang, South Korea
  • 2009–2014
    • Korea University
      • Department of Chemical and Biological Engineering
      Sŏul, Seoul, South Korea
    • Gyeongsang National University
      • Department of Internal Medicine
      Chinju, South Gyeongsang, South Korea
    • Eulji University
      Daiden, Daejeon, South Korea
  • 2008–2014
    • Chonbuk National University
      Tsiuentcheou, North Jeolla, South Korea
  • 2002–2014
    • Catholic University of Korea
      • • Department of Hospital Pathology
      • • Department of Pediatrics
      • • College of Medicine
      Sŏul, Seoul, South Korea
  • 2013
    • CHA University
      • School of Medicine
      Seoul, Seoul, South Korea
    • Inha University
      • Department of Plastic Surgery
      Seoul, Seoul, South Korea
  • 2010–2013
    • Kyungpook National University
      • • Department of Chemistry
      • • School of Medicine
      Daikyū, Daegu, South Korea
    • Chung-Ang University Hospital
      Sŏul, Seoul, South Korea
    • Kyung Hee University
      • Department of Medicine
      Seoul, Seoul, South Korea
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2004–2013
    • Inha University Hospital
      Sinhyeon, South Gyeongsang, South Korea
  • 2010–2012
    • Kyung Hee University Medical Center
      Sŏul, Seoul, South Korea
  • 2009–2012
    • Asan Medical Center
      Sŏul, Seoul, South Korea
  • 2007–2012
    • Yonsei University
      • • College of Life Science and Biotechnology
      • • Department of Mathematics
      • • Department of Biology
      Seoul, Seoul, South Korea
  • 2010–2011
    • University of Minnesota Duluth
      Duluth, Minnesota, United States
  • 2001–2010
    • Seoul National University
      • • Department of Health Policy and Management
      • • Department of Materials Science and Engineering
      • • Department of Pathology
      • • Division of Chemistry and Molecular Engineering
      Seoul, Seoul, South Korea
  • 2007–2008
    • Sungkyunkwan University
      • Department of Nuclear Medicine
      Sŏul, Seoul, South Korea
  • 2006
    • International St. Mary's Hospitals
      Chemulpo, Incheon, South Korea
  • 2003
    • Kyungsung University
      • Department of Food Science and Biotechnology
      Tsau-liang-hai, Busan, South Korea
    • Seegene Institute of Life Sciences
      Sŏul, Seoul, South Korea