[show abstract][hide abstract] ABSTRACT: The potential for genome-wide association studies to relate phenotypes to specific genetic variation is greatly increased when data can be combined or compared across multiple studies. To facilitate replication and validation across studies, RTI International (Research Triangle Park, North Carolina) and the National Human Genome Research Institute (Bethesda, Maryland) are collaborating on the consensus measures for Phenotypes and eXposures (PhenX) project. The goal of PhenX is to identify 15 high-priority, well-established, and broadly applicable measures for each of 21 research domains. PhenX measures are selected by working groups of domain experts using a consensus process that includes input from the scientific community. The selected measures are then made freely available to the scientific community via the PhenX Toolkit. Thus, the PhenX Toolkit provides the research community with a core set of high-quality, well-established, low-burden measures intended for use in large-scale genomic studies. PhenX measures will have the most impact when included at the experimental design stage. The PhenX Toolkit also includes links to standards and resources in an effort to facilitate data harmonization to legacy data. Broad acceptance and use of PhenX measures will promote cross-study comparisons to increase statistical power for identifying and replicating variants associated with complex diseases and with gene-gene and gene-environment interactions.
American journal of epidemiology 08/2011; 174(3):253-60. · 5.59 Impact Factor
[show abstract][hide abstract] ABSTRACT: To examine the health status of women in relationship to the targets for the Healthy People 2010 ten Leading Health Indicators (LHIs), this paper compares females and males, as well as females by age groups. The data presented in this study were collected from publicly available sources, including Healthy People 2010 publications and websites, as well as Health US 2000. In addition, the lead agency Department of Health and Human Services workgroup coordinators provided clarifying information. Women were found to have better health status than men on half of the LHIs. When examined by age, data for the LHIs provide additional insights on where to target interventions to improve women's health. For adolescent females, the biggest challenges to meet the year 2010 targets are in reducing tobacco use, obesity, motor vehicle deaths, and homicides. For adult females, the greatest public health challenges are in increasing physical activity, reducing obesity, and obtaining immunizations.
Women s Health Issues 01/2002; 12(4):155-64. · 1.61 Impact Factor
[show abstract][hide abstract] ABSTRACT: For the first decade of the new millennium, "Healthy People 2010" will be the official designation of the health promotion and disease prevention policy of the United States of America. The policy's work plan carries on the vision of Health for All that is promoted by the World Health Organization and the Pan American Health Organization and whose attainment will be the responsibility of each and every person on earth. Healthy People in Healthy Communities, as the approach to Healthy People 2010 will be called, will have two general objectives for the United States as a whole. One is to increase the years of healthy life, incorporating the concept of quality of life into that of healthy life expectancy. The second objective is to eliminate health disparities. Twenty-eight priority areas and more than 400 goals will be consolidated through community initiatives and close communication among the public, health authorities, and community leaders. The experience of the United States is particularly interesting because it is participatory, as shown by the creation and consolidation of alliances between numerous sectors, bipartisan political support, use of scientific tests to support decisions, and efforts to strengthen data collection processes. The broad acceptance and adoption of the objectives of Healthy People by practically all fifty states reaffirms the initiative's validity in various socioeconomic and cultural contexts. Healthy People 2010 will be launched publicly during a conference that will be held in Washington, D.C., from 24 to 28 January 2000, with support from the Healthy People Consortium and the Partnerships for Networked Consumer Health Information.
[show abstract][hide abstract] ABSTRACT: The Public Health Foundation (PHF), under contract to the U.S. Department of Health and Human Services, Public Health Service (PHS), worked with federal, state, and local public health, mental health, substance abuse, and environmental agencies in nine states to develop and successfully test a methodology for estimating investments in essential public health services. Estimates from the nine-state sample revealed the predominance of personal health expenditures in the public health system. Of total state health care dollars, only 1 percent was spent on population-based health services by participating agencies. This pilot provides a rational starting point toward a uniform methodology for highlighting public health expenditures that may be critical in revealing the effects of a changing health care environment on the nation's health. In combination with other data, results are expected to lead to a more informed policy-making process.
Journal of public health management and practice: JPHMP 06/1997; 3(3):1-9. · 0.96 Impact Factor