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Publications (2)1.72 Total impact

  • Xu Zhao · Tiancheng Ma · Chenning Zhang · Shaohuai Shi · Sijiao Cui · Kaishun Bi · Ying Jia ·
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    ABSTRACT: A selective liquid chromatographic–mass spectrometric method has been developed and validated for simultaneous determination of senkyunolide I (SEI) and senkyunolide H (SEH) from Chuanxiong Rhizoma in rat plasma. Plasma samples were extracted by liquid–liquid extraction with ethyl acetate and separated on a Kromasil C18 column (250 × 4.6 mm, 5 µm), with methanol–water (55:45, v/v) as mobile phase. The linear range was 0.05–25 µg/mL for SEI and 0.01–5.0 µg/mL for SEH, with lower limits of quantitation of 0.05 and 0.01 µg/mL, respectively. Intra- and inter-day precision were within 10.0 and 9.8%, and the accuracies (relative errors) were <9.6 and 5.9%, with the mean extraction recoveries 81.0–86.6 and 80.5–85.0% for the two anayltes, respectively. The validated method was successfully applied to a comparative pharmacokinetic study of SEI and SEH in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract. The results indicated that there were obvious differences between normal and migrainous rats in the pharmacokinetic behavior after oral administration of Chuanxiong Rhizoma extract. The absorption of SEI and SEH were significantly increased in migrainous rats compared with normal rats. Copyright © 2015 John Wiley & Sons, Ltd.
    Biomedical Chromatography 01/2015; 29(9). DOI:10.1002/bmc.3420 · 1.72 Impact Factor
  • Xuhang Fan · Zhenzhong Wang · Qing Li · Tiancheng Ma · Kaishun Bi · Ying Jia ·
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    ABSTRACT: To develop an UPLC method of determining the characteristic chromatographic profiles of Moutan Cortex for quality control of the medicine. The UPLC characteristic chromatographic profiles of fifteen batches of Moutan Cortex were determined on an HSS T3 column (2.1 mm x 100 mm, 1.8 microm) eluted with the mobile phase consisted of water containing 0.05% phosphoric acid and acetonitrile in gradient mode and the detection wavelength was set at 254 nm. The common mode of the UPLC characteristic chromatographic profile was set up under the established condition. There were 20 common peaks in the characteristic chromatographic profile of fifteen samples, ten of which were identified, and the similar degrees of the fifteen batches to the common mode were between 0.973-0.998. The method was fast and accurate. The characteristic chromatographic profile of Moutan Cortex with high specificity can be used to control the quality of Moutan Cortex.
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 03/2011; 36(6):715-7.