Masahiro Ishino

Publications (2)6.26 Total impact

• Article: Pyridone Alkaloids from a Marine-Derived Fungus, Stagonosporopsis cucurbitacearum, and Their Activities against Azole-Resistant Candida albicans.

  Asami Haga, Hiroki Tamoto, Masahiro Ishino, Eriko Kimura, Takashi Sugita, Kaoru Kinoshita, Kunio Takahashi, Motoo Shiro, Kiyotaka Koyama
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  ABSTRACT: Four new 4-hydroxy-2-pyridone alkaloids, didymellamides A-D (1-4), were isolated from the marine-derived fungus Stagonosporopsis cucurbitacearum. The structures of 1-4 were elucidated from spectroscopic data (NMR, MS, and IR), and the absolute configuration of 1 was determined by X-ray diffraction analysis. Didymellamide A (1) exhibited antifungal activity against azole-resistant Candida albicans.
  Journal of Natural Products 03/2013; · 3.13 Impact Factor
• Article: Chemical constituents of a marine fungus, Arthrinium sacchari.

  Mariko Tsukada, Miyuki Fukai, Kazuhiko Miki, Takeshi Shiraishi, Toshihiro Suzuki, Kazuto Nishio, Takashi Sugita, Masahiro Ishino, Kaoru Kinoshita, Kunio Takahashi, Motoo Shiro, Kiyotaka Koyama
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  ABSTRACT: Three new diterpenes, myrocin D (1), libertellenone E (2), and libertellenone F (3), and a new isocoumarin, decarboxyhydroxycitrinone (4), were isolated from the marine fungus Arthrinium sacchari, together with three known compounds (5-7). The structures of 1-4 were elucidated from spectroscopic data (NMR, MS, IR), and the absolute configurations of 1-3 were determined by X-ray diffraction analysis. The antiangiogenic activity of these compounds was evaluated by measuring their antiproliferation effects on human umbilical vein endothelial cells (HUVECs) and human umbilical artery endothelial cells (HUAECs). Compounds 4-7 showed inhibitory activity.
  Journal of Natural Products 06/2011; 74(7):1645-9. · 3.13 Impact Factor