Bin Kang

Publications (2)16.85 Total impact

• Article: Human histone acetyltransferase HAT1 preferentially acetylates H4 molecules in H3.1-H4 dimers over H3.3-H4 dimers

  Hui Zhang, Junhong Han, Bin Kang, Rebecca Burgess, Zhiguo Zhang
  Journal of Biological Chemistry 01/2012; January 7, 2012, doi: 10.1074/jbc.M111.312637. · 4.77 Impact Factor
• Article: Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly.

  Bin Kang, Mintie Pu, Gangqing Hu, Weihong Wen, Zigang Dong, Keji Zhao, Bruce Stillman, Zhiguo Zhang
  [show abstract] [hide abstract]
  ABSTRACT: Histone H3 variant H3.3, while differing from canonical H3 (H3.1) by only five amino acids, is assembled into nucleosomes, along with histone H4, at genic regions by the histone chaperone HIRA, whereas H3.1 is assembled into nucleosomes in a CAF-1-dependent reaction. Here, we show that phosphorylation of histone H4 Ser 47 (H4S47ph), catalyzed by the PAK2 kinase, promotes nucleosome assembly of H3.3-H4 and inhibits nucleosome assembly of H3.1-H4 by increasing the binding affinity of HIRA to H3.3-H4 and reducing association of CAF-1 with H3.1-H4. These results reveal a mechanism whereby H4S47ph distinctly regulates nucleosome assembly of H3.1 and H3.3.
  Genes & development 07/2011; 25(13):1359-64. · 12.08 Impact Factor