Publications (4)4.62 Total impact
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ABSTRACT: Objectives: The causal role of some cardiovascular risk factors, such as HDL cholesterol, has been increasingly challenged and attention is returning to all elements of Virchow's triad, i. e., hypercoagulability (including viscosity) as well as endothelial function and blood flow. We examined the life course origins of coagulability. Methods: We used multivariable linear regression to assess whether childhood influences, proxied by height and its components, were associated with hematocrit (Hct), hemoglobin (HGB), and other hematological parameters in 28,595 older Chinese adults (mean age=61.8 years) from the Guangzhou Biobank Cohort Study. Results: Adjusted for age, sex, and recruitment phase, leg length was negatively associated with platelets (PLT) (-0.83 x 10(9) /l per centimeter (cm), 95% confidence interval (CI) -1.01 to -0.65). Sitting height and height were positively associated with Hct (0.05% per cm, 95% CI 0.04-0.07 for sitting height; 0.02% per cm, 95% CI 0.01-0.02 for height), HGB (0.21 g/l per cm, 95% CI 0.17-0.25; 0.07 g/l per cm, 95% CI 0.04-0.09) and negatively associated with PLT (-1.2 x 10(9) /l per cm, 95% CI -1.4 to -1.0; -0.83 x 10(9) /l per cm, 95% CI -0.95 to -0.70). Further adjustment for potential confounders did little to change the estimates. Conclusions: For the first time we provide anthropometric evidence for the different roles of prepubertal and pubertal influences in relation to Hct and HGB. Whether factors that promote leg growth but reduce growth of sitting height may help to prevent cardiovascular events, via effects on hypercoagulability or viscosity, overall or in specific subgroups, remains to be determined. (C) 2014Wiley Periodicals, Inc.American Journal of Human Biology 09/2014; 26(5). DOI:10.1002/ajhb.22568 · 1.93 Impact Factor
- Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 01/2013; 14(11):412-420.
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ABSTRACT: Cross-sectional associations between white blood cell (WBC) count, lymphocyte and granulocyte numbers, and carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (PWV) were examined in a novel older Chinese community sample. A total of 817 men and 760 women from a sub-study of the Guangzhou Biobank Cohort Study had a full blood count measured by an automated hematology analyzer, carotid IMT by B-mode ultrasonography and brachial-ankle PWV by a non-invasive automatic waveform analyzer. Following adjustment for confounders, WBC count (β=0.07, P<0.001) and granulocyte (β=0.07, P<0.001) number were significantly positively related to PWV, but not lymphocyte number. Similarly, WBC count (β=0.08, P=0.03), lymphocyte (β=0.08, P=0.002) and granulocyte (β=0.03, P=0.04) number were significantly positively associated with carotid IMT, but only the association with lymphocyte count survived correction for other cardiovascular risk factors. In conclusion, higher WBC, particularly lymphocyte and granulocyte, count could be used, respectively, as markers of cardiovascular disease risk, measured through indicators of atherosclerosis and arterial stiffness. The associations for WBC count previously observed by others were likely driven by higher granulocytes; an index of systemic inflammation.Journal of human hypertension 06/2011; 26(8):485-92. DOI:10.1038/jhh.2011.58 · 2.69 Impact Factor
- Zhonghua shen jing ke za zhi = Chinese journal of neurology 01/2010; 43(9):617-621.
Guangzhou First People's HospitalShengcheng, Guangdong, China