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ABSTRACT: Volvalerenol A (1), an unprecedented type of triterpenoid with a 7/12/7 tricyclic ring system, was obtained from the ethanol extracts of the roots of Valeriana hardwickii. The structure and relative configurations were established by comprehensive analysis of MS and NMR spectroscopic data. The possible biogenetic pathway of 1 was also deduced.
Organic Letters 06/2013; · 5.86 Impact Factor
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ABSTRACT: Three new lanostanoid triterpenes, 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid (1), 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 3β,15β-dihydroxy-7,11,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester (3) were isolated from the EtOAc extract of the fruiting bodies of Ganoderma tropicum. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) of these isolates was evaluated and compound 2 exhibited definite inhibitory activity against AChE.
Journal of Asian natural products research 02/2013; · 0.61 Impact Factor
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ABSTRACT: To study the chemical constituents from Daphne acutiloba.
The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses.
Fifteen compounds were isolated from the EtOAc extract and identified as wikstroelide M (1), vesiculosin (2), prostratin (3), 7-hydroxy-coumarin (4), 7,8-di-hydroxy-coumarin (5), isodaphnoside (6), daphnorine (7), rutamontine (8), daphnolin (9), daphneticin (10), (+)-pinoresinol-beta-D-glucoside (11), oleodapnone (12), oleodaphnal (13), ergosterol peroxide (14) and cholest-5-en-3beta-ol (15).
All the compounds except for 4, 5 and 14 were obtained from the stems of this plant for the first time.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 01/2013; 38(1):64-9.
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ABSTRACT: One new compound named amauroamoienin (1), together with thirteen known compounds (2-14), was isolated from the EtOAc extract of Amauroderma amoiensis. The structures of these compounds were elucidated by the analysis of 1D and 2D spectroscopic data and the MS technique. The bioassays of inhibitory activities of these isolates against acetylcholinesterase were evaluated, and compounds 1, 3, and 5 exhibited acetylcholinesterase inhibitory activities.
Planta Medica 11/2012; · 2.15 Impact Factor
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ABSTRACT: Three new sesquiterpenes dobinins A-C (1-3), together with five known compounds, were isolated from the root of Dobinea delavayi. The structures of the three new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR and MS techniques as well as by comparison of the spectral data with those of analogous compounds reported in the literatures. Compounds 1-3 were screened for antitumor activity in vitro and exhibited definite cytotoxic activity against the human tumor cell line HL-60 with IC50 levels of 8.0 × 10-5, 4.7 × 10-5, and 5.1 × 10-5 M, respectively.
Planta Medica 09/2012; · 2.15 Impact Factor
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Sheng Zhuo Huang,
Xing Jie Zhang,
Xing Yao Li,
He Zhong Jiang, Qing Yun Ma,
Peng Cheng Wang,
Yu Qing Liu,
Jiang Miao Hu,
Yong Tang Zheng,
Jun Zhou,
You Xing Zhao
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ABSTRACT: The present paper describes the study of the phytochemical properties and anti-HIV activity of the phenolic isolates of the plateau medicinal plant Daphne acutiloba Rehd. (Thymelaeceae). Two new lignans named daphnenin (1) and daphnetone (2), along with 11 known ones, were isolated, and their structures were elucidated by 1D and 2DNMR spectroscopy aswell as HR‑ESI‑MS. In the anti-HIV activity study, daphnenin (1) and caffeic acid n-octadecyl ester (13) showed definite anti-HIVactivity with EC(50) values of 0.39 and 0.16 μg/mL, respectively.
Planta Medica 01/2012; 78(2):182-5. · 2.15 Impact Factor
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ABSTRACT: Two new daucane sesquiterpenoids 1β,2β-epoxy-10(H)α-dauca-11(12)-ene-7α,14-diol and 1α,2α-epoxy-10(H)α-dauca-11(12)-ene-7α,14-diol were isolated from the plateau medicinal plant Daphne aurantiaca Diels. (Thymelaeceae). Their structures were elucidated by 1D and 2D NMR spectroscopy, as well as HR-ESI-MS data.
Molecules 01/2012; 17(9):10046-51. · 2.39 Impact Factor
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Sheng Zhuo Huang,
Xing Jie Zhang,
Xing Yao Li,
Ling Mei Kong,
He Zhong Jiang, Qing Yun Ma,
Yu Qing Liu,
Jiang Miao Hu,
Yong Tang Zheng,
Yan Li,
Jun Zhou,
You Xing Zhao
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ABSTRACT: Seven previously unreported daphnane-type diterpene esters named acutilobins A-G, together with 12 known ones, were isolated from EtOAc extract of Daphne acutiloba Rehd. Their structures were elucidated based on the spectroscopic data. The cytotoxic and anti-HIV-1 activities of these daphnane-type diterpene esters were evaluated through bioassays. Fourteen of these isolates exhibited definite cytotoxic activities against the five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. Additionally, anti-HIV-1 activities were observed in 13 daphnane-type diterpene esters, among which acutilobins A-G exhibited significant anti-HIV-1 activities with EC₅₀ below 1.5 nM and SI over 10,000. Particularly, genkwanineVIII showed the strongest activity with EC₅₀ 0.17 nM and SI 187,010.
Phytochemistry 12/2011; 75:99-107. · 3.35 Impact Factor
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Peng-Cheng Wang,
Xin-Hui Ran,
Rui Chen,
Huai-Rong Luo, Qing-Yun Ma,
Yu-Qing Liu,
Jiang-Miao Hu,
Sheng-Zhuo Huang,
He-Zhong Jiang,
Zhong-Quan Chen,
Jun Zhou,
You-Xing Zhao
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ABSTRACT: Two new guaiane-type sesquiterpenoids, valerol A (1) and kessyl 3-acetate (2), together with nine known compounds, valeracetate (3), anismol A (4), orientalol C (5), spatulenol (6), 4α,10α-epoxyaromadendrane (7), (+)-8-hydroxypinoresinol (8), pinorespiol (9), pinoresinol 4-O-β-D-glucopyranoside (10), and 8-hydroxypinoresinol 4'-O-β-D-glucopyranoside (11) were isolated from the roots of Valeriana officinalis. The structures and relative configurations of 1 and 2 were elucidated on the basis of spectroscopic methods (1D- and 2D-NMR, MS, UV, and IR). These compounds were evaluated for inhibitory activity on acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.
Chemistry & Biodiversity 10/2011; 8(10):1908-13. · 1.80 Impact Factor
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ABSTRACT: Natural products inhibiting fatty acid synthase (FAS) are appearing as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Nephelium lappaceum L. resulted in the isolation of ten compounds (1-10) mainly including flavonoids and oleane-type triterpene oligoglycosides, in which all of the compounds were isolated from this plant for the first time. Additionally, compounds 8 and 9 were new hederagenin derivatives and were elucidated as hederagenin 3-O-(2,3-di-O-acetyl-α-l-arabinofuranosyl)-(1→3)-[α-l-rhamnopyranosyl(1→2)]-β-l-arabinopyranoside and hederagenin 3-O-(3-O-acetyl-α-l-arabinofuranosyl)-(1→3)-[α-l-rhamnopyranosyl-(1→2)]-β-l-arabinopyranoside, respectively. All these isolates were evaluated for inhibitory activities of FAS, which showed these isolates had inhibitory activity against FAS with IC(50) values ranging from 6.69 to 204.40 μM, comparable to the known FAS inhibitor EGCG (IC(50)=51.97 μM). The study indicates that the hulls of Nephelium lappaceum L. could be considered as potential sources of promising FAS inhibitors and the oleane-type triterpene oligoglycosides could be considered as another type of natural FAS inhibitors.
Carbohydrate research 08/2011; 346(11):1302-6. · 2.03 Impact Factor
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Peng-Cheng Wang,
Xin-Hui Ran,
Huai-Rong Luo,
Jiang-Miao Hu,
Rui Chen, Qing-Yun Ma,
Hao-Fu Dai,
Yu-Qing Liu,
Ming-Jin Xie,
Jun Zhou,
You-Xing Zhao
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ABSTRACT: Volvalerelactones A and B (1 and 2), two new sesquiterpenoid lactones with an unprecedented 3/7/6 tricyclic ring system, were isolated from the roots of Valeriana officinalis var. latifolia. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction crystallography, and the absolute configuration was assigned by computational methods. The possible biosynthetic pathways of 1 and 2 were also proposed.
Organic Letters 06/2011; 13(12):3036-9. · 5.86 Impact Factor
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ABSTRACT: To study the chemical constituents of the herb of Antenoron filiforme.
The constituents were separated by column chromatography and their structures were elucidated by spectral data analyses.
Eleven compounds were isolated from the ethanol extract of A. filiforme and identified as, bronane-5-hydroxy-2-O-beta-D-glucopyranoside (I), adenosine (II), bonaroside (III), rhamnetin (IV), hyperoside (V), rhamnetin-3-O-beta-D-galactopyranoside (VI), kaempferol-3, 7-O-bis-alpha-L-rhamnopyranoside (VII), stigmasterol (VIII), nonacosanoic acid (IX), daucosterol (X), 3beta-sitosterol (XI).
All compounds are obtained from A. filiforme for the first time.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 05/2011; 34(5):704-7.
