Qing-Yun Ma

Chinese Academy of Tropical Agricultural Sciences, Hoihau, Hainan, China

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Publications (28)49.02 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Three new lanostanoid triterpenes-ganotropic acid (1), 3β,7β,15α,24-tetra- hydroxy-11,23-dioxo-lanost-8-en-26-oic acid (2) and 3β,7β,15α,28-tetrahydroxy-11,23- dioxo-lanost-8,16-dien-26-oic acid (3)-were isolated from the n-BuOH extract of the fruiting bodies of the mushroom Ganoderma tropicum. Their structures were elucidated by 1D and 2D NMR spectroscopy, as well as HR-EI-MS data.
    Molecules 02/2015; 20(2):3281-9. DOI:10.3390/molecules20023281 · 2.42 Impact Factor
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    ABSTRACT: Nine lanostanoids, together with nine known ones, were isolated from the ethyl acetate extract of the fruiting bodies of the mushroom Haddowia longipes. Their structures were elucidated as 11-oxo-ganoderiol D, lanosta-8-en-7,11-dioxo-3β-acetyloxy-24,25,26-trihydroxy, lanosta-8-en-7-oxo-3β-acetyloxy-11β,24,25,26-tetrahydroxy, lanosta-7,9(11)-dien-3β-acetyloxy-24,25,26-trihydroxy, lanosta-7,9(11)-dien-3β-acetyloxy-24,26-dihydroxy-25-methoxy, 11-oxo-lucidadiol, 11β-hydroxy-lucidadiol, lucidone H and lanosta-7,9(11),24E-trien-3β-acetyloxy-26,27-dihydroxy by analysing their 1D/2D NMR and MS spectra. In addition, bioassays of inhibitory activity against acetylcholinesterase (AChE) of all compounds showed that thirteen compounds possessed inhibitory activity against AChE with the percentage inhibition ranging from 10.3% to 42.1% when tested at 100 μM.
    Phytochemistry 01/2015; 110. DOI:10.1016/j.phytochem.2014.12.012 · 3.35 Impact Factor
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    ABSTRACT: Six new compounds, including two diterpenoids excocarinols F and G (1 and 2, resp.), two carotane (daucane) sesquiterpenoids excoecafolinols A and B (3 and 4, resp.), one lignanoid compound, excoecanol A (5), and one simple phenol, excoecanol B (6), together with 17 known compounds, were isolated from the BuOH extract of Excoecaria acerifolia Didr. stems. Their structures were elucidated through the analysis of the spectroscopic data. The AChE-inhibitory activities of 17 compounds were evaluated and revealed that four of them possessed moderate inhibitory activities against AChE.
    Chemistry & Biodiversity 09/2014; 11(9):1406-16. DOI:10.1002/cbdv.201400087 · 1.80 Impact Factor
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    ABSTRACT: Two new sesquiterpenoids with guaiane skeletons-holosericin A (1) and holosericin B (2)-were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition.
    Molecules 09/2014; 19(9):14266-14272. DOI:10.3390/molecules190914266 · 2.42 Impact Factor
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    ABSTRACT: Eight tetranortriterpenoids (1-8) and two sesquiterpenoids (9 and 10) including two new compounds, cineracipadesin G (1) and 1β-hydroperoxy-6α-hydroxy-eudesm-4(15)-ene (9), were isolated from the EtOAc extract of branches of Cipadessa cinerascens. The structures of two new compounds were elucidated by 1D and 2D NMR and MS spectroscopic analyses. The anti-feedant activity of two tetranortriterpenoids (1 and 7) was tested and obvious anti-feedant effects were detected.
    Journal of Asian Natural Products Research 08/2014; 16(11):1-6. DOI:10.1080/10286020.2014.938060 · 0.97 Impact Factor
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    ABSTRACT: Daphnauranols A-C (1-3), three new sesquiterpenoids with an unprecedented 5/6/7 ring system, were isolated from the stems of Daphne aurantiaca Diels. Their structures were elucidated on the basis of comprehensive spectroscopic methods including MS and NMR. The absolute configuration of daphnauranol A was further confirmed by single crystal X-ray diffraction (Cu Kα). Their anti-feedant activity was tested, and the fruit fly antifeedant index (AI) were 39.87.2 %, 29.47.2 %, and 26.36.4 %, respectively.
    Tetrahedron Letters 07/2014; 55(27). DOI:10.1016/j.tetlet.2014.05.007 · 2.39 Impact Factor
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    ABSTRACT: Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerifolia Didr.. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 μM, SI >1,836.9, 431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.
    Fitoterapia 06/2014; 95. DOI:10.1016/j.fitote.2014.02.018 · 2.22 Impact Factor
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    ABSTRACT: The chemical investigation on Ganoderma philippii led to the isolation of sixteen compounds by silica gel and Sephadex LH-20 column chromatography. On the basis of spectroscopic data analyses, their structures were elucidated as 2, 5-dihydroxyacetophenone (1), methyl gentisate (2), (S) -dimethyl malate (3), muurola-4, 10 (14) -dien-11beta-ol (4), dihydroepicubenol (5), 5-hydroxymethylfuran carboxaldehyde (6), ergosta-7, 22E-dien-3beta-ol (7), ergosta-7, 22E-dien-3-one (8), ergosta-7, 22E-diene-2beta, 3alpha, 9alpha-triol (9), 6/beta-methoxyergo-sta-7, 22E-dien-3beta, 5alpha-diol (10), ergosta-4, 6, 8(14), 22E-tetraen-3-one (11), ergosta4, 6, 8-(14), 22E-etetraen-3beta-ol (12), 5alpha, 8alpha-epidioxy-ergosta-6, 22E-dien-3beta-ol (13), 7alpha-methoxy-5alpha, 6alpha-epoxyergosta-8-(14), 22E-dien-3beta-ol (14), ergosta-8, 22E-diene-3beta, 5alpha, 6beta, 7alpha-tetraol (15), and ergosta-5, 23-dien-3beta-ol, acetate (16). All the compounds were obtained from this fungus for the first time, and compounds 4 and 5 were isolated from the Ganoderma genus for the first time.
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    ABSTRACT: Ganoderma tropicum has been widely used by the local folks for coronary heart disease treatment, liver protection, and sleep aid. In order to discover natural active components and tap the medical potential of G. tropicum, the chemical investigation of its fruiting bodies was carried out. This study led to the isolation of a new nortriterpenoid named 26-nor-11,23-dioxo-5α-lanost-8-en-3β,7β,15α,25-tetrol (1) and a known nortriterpenoid lucidone D (2). The structure of the new nortriterpenoid was elucidated by spectroscopic techniques including UV, IR, MS, 1D and 2D NMR spectroscopy.
    Phytochemistry Letters 02/2014; 7(1):11–13. DOI:10.1016/j.phytol.2013.09.004 · 1.54 Impact Factor
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    ABSTRACT: Five new diterpenoids named excocarinols A-E (1-5) including three pimaranes, one cleistanthane, and one nor-beyrane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D-NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58 μM and SI (Selection Index) over 112.71.
    Fitoterapia 09/2013; 91. DOI:10.1016/j.fitote.2013.09.007 · 2.22 Impact Factor
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    ABSTRACT: A new benzofuran neolignan, dihydrodehydrodiconiferyl alcohol 9-isovalerate, along with ten known phenolic compounds, olivil, pinoresinol, 8-hydroxypinoresinol, pinorespiol, 8-hydroxy7-epipinoresinol, trans-p-hydroxyphenyl- propenoic acid, cis-p-hydroxyphenyl-propenoic acid, ferulic acid, isoferulic acid and isovanillin were isolated from the roots of Valeriana officinalis var. latifolia. Their structures and configurations were elucidated on the basis of spectroscopic methods. The inhibitory activity for acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells of dihydrodehydrodiconiferyl alcohol 9-isovaterate and olivil were evaluated.
    Journal of the Brazilian Chemical Society 09/2013; 24(9):1544-1548. DOI:10.5935/0103-5053.20130184 · 1.25 Impact Factor
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    ABSTRACT: Twelve lanostane triterpenoids (1-12) including a new one 16α,26-dihydroxylanosta-8,24-dien-3-one (1) were isolated from the fruiting bodies of Ganoderma hainanense. The structure of the new compound was elucidated by 1D and 2D NMR and MS spectroscopic analyses. All isolates were evaluated for their cytotoxicities against human tumor cell lines K-562, SMMC-7721, and SGC-7901 and five compounds (1, 2, 5, 7, and 9) showed definite cytotoxicities against K-562 cell line. Meanwhile, compounds 2, 5, 7, and 9 exhibited cytotoxic activities against SMMC-7721 and SGC-7901 cell lines.
    Journal of Asian natural products research 08/2013; 15(11). DOI:10.1080/10286020.2013.820712 · 0.97 Impact Factor
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    ABSTRACT: Three new isopimarane diterpenoids named excoecarins F-H (1-3) were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioactivity test of 1 and 2 showed weak activity.
    Journal of Asian natural products research 06/2013; 15(7). DOI:10.1080/10286020.2013.800862 · 0.97 Impact Factor
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    ABSTRACT: Volvalerenol A (1), an unprecedented type of triterpenoid with a 7/12/7 tricyclic ring system, was obtained from the ethanol extracts of the roots of Valeriana hardwickii. The structure and relative configurations were established by comprehensive analysis of MS and NMR spectroscopic data. The possible biogenetic pathway of 1 was also deduced.
    Organic Letters 06/2013; 15(12). DOI:10.1021/ol4013662 · 6.32 Impact Factor
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    ABSTRACT: Chemical investigation of the fruiting bodies of Ganoderma tropicum led to the isolation of two new phenolic compounds, ganodermatropins A (1) and B (2). Their structures were elucidated by spectroscopic techniques (MS, 1D and 2D NMR). Ganodermatropin A exhibited antimicrobial activity against Staphylococcus aureus.
    Bulletin- Korean Chemical Society 03/2013; 34(3). DOI:10.5012/bkcs.2013.34.3.884 · 0.84 Impact Factor
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    ABSTRACT: A new benzophenone sesquiterpene dobiniside A (1), together with two known compounds, 4′,6-dihydroxy-2,3′,4-trimethoxybenzophenone (2) and mangiferin (3), were isolated from the root of Dobinea delavayi. The structure of the new compound was determined on the basis of spectroscopic analysis, including 1D, 2D NMR, and FAB-MS techniques as well as by comparison of the spectral data with those of related compounds reported in the literature. Compounds 1–3 were screened for antitumor activity in vitro, and compound 3 was shown to possess antitumor activity with IC50 value of 7.4 × 10–5 μM for A-549.
    Chemistry of Natural Compounds 03/2013; 49(1). DOI:10.1007/s10600-013-0502-7 · 0.50 Impact Factor
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    ABSTRACT: Three new lanostanoid triterpenes, 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid (1), 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 3β,15β-dihydroxy-7,11,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester (3) were isolated from the EtOAc extract of the fruiting bodies of Ganoderma tropicum. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) of these isolates was evaluated and compound 2 exhibited definite inhibitory activity against AChE.
    Journal of Asian natural products research 02/2013; 15(4). DOI:10.1080/10286020.2013.764869 · 0.97 Impact Factor
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    ABSTRACT: To study the chemical constituents from Daphne acutiloba. The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. Fifteen compounds were isolated from the EtOAc extract and identified as wikstroelide M (1), vesiculosin (2), prostratin (3), 7-hydroxy-coumarin (4), 7,8-di-hydroxy-coumarin (5), isodaphnoside (6), daphnorine (7), rutamontine (8), daphnolin (9), daphneticin (10), (+)-pinoresinol-beta-D-glucoside (11), oleodapnone (12), oleodaphnal (13), ergosterol peroxide (14) and cholest-5-en-3beta-ol (15). All the compounds except for 4, 5 and 14 were obtained from the stems of this plant for the first time.
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 01/2013; 38(1):64-9.
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    ABSTRACT: Two new daucane sesquiterpenoids 1β,2β-epoxy-10(H)α-dauca-11(12)-ene-7α,14-diol and 1α,2α-epoxy-10(H)α-dauca-11(12)-ene-7α,14-diol were isolated from the plateau medicinal plant Daphne aurantiaca Diels. (Thymelaeceae). Their structures were elucidated by 1D and 2D NMR spectroscopy, as well as HR-ESI-MS data.
    Molecules 12/2012; 17(9):10046-51. DOI:10.3390/molecules170910046 · 2.42 Impact Factor
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    ABSTRACT: Three new sesquiterpenes dobinins A-C (1-3), together with five known compounds, were isolated from the root of Dobinea delavayi. The structures of the three new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR and MS techniques as well as by comparison of the spectral data with those of analogous compounds reported in the literatures. Compounds 1-3 were screened for antitumor activity in vitro and exhibited definite cytotoxic activity against the human tumor cell line HL-60 with IC50 levels of 8.0 × 10-5, 4.7 × 10-5, and 5.1 × 10-5 M, respectively.
    Planta Medica 09/2012; 78(17). DOI:10.1055/s-0032-1315369 · 2.34 Impact Factor

Publication Stats

40 Citations
49.02 Total Impact Points

Institutions

  • 2011–2015
    • Chinese Academy of Tropical Agricultural Sciences
      Hoihau, Hainan, China
  • 2013
    • Government of the People's Republic of China
      Peping, Beijing, China