[Show abstract][Hide abstract] ABSTRACT: The aim of this study was to assess adiponectin, visfatin, HOMA-IR, glucose and triglyceride levels in term, preterm and extremely low birth weight (ELBW) babies. Each of these three groups was subdivided into two groups as small-for-gestational age (SGA), and appropriate-for-gestational age (AGA). 30 term, 30 preterm and 30 extremely low birth weight infants were included into the study.
There was no significant difference in term and preterm infants for serum adiponectin, visfatin, and HOMA-IR levels. There were also no significant differences between term and preterm infants for glucose and triglycerides. The serum visfatin, insulin and HOMA-IR levels (p = 0.001, p = 0.001 and p < 0.05, respectively) were higher in ELBW group than preterm group. Comparing the subgroups as SGA and AGA in all main groups, only in ELBW group there were no significant differences in serum adiponectin, visfatin, HOMA-IR and insulin levels.
We suggest that visfatin can be used as an early indicator of insulin resistance. Independent of being SGA, ELBW itself may be a risk factor for insulin resistance. In the follow-up of these babies the risk of obesity, metabolic syndrome and cardiovascular diseases may be increased as in SGA babies.
European review for medical and pharmacological sciences 02/2013; 17(4):501-6. · 0.99 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The aim of this study was to investigate the relationship between maternal risk factors, neonatal demographic features and asymmetric dimethylarginine (ADMA) levels in a randomly selected group of pregnancies during delivery. The subjects were categorized into five groups as having: no maternal risk factor, maternal hypertension, gestational diabetes, maternal smoking history, and meconium staining. Blood samples were taken from the mothers before delivery and from the umbilical vein after delivery. Mean ADMA levels were significantly lower in the cord blood when compared with maternal levels in all groups. Mean ADMA level of neonates in the meconium staining group was found to be significantly higher than in the other groups (p<0.001). Maternal age, delivery type, parity and sex did not show any effect on cord blood ADMA levels. Overall, umbilical vein ADMA levels are modulated independent of several maternal features and risk factors. Although these factors are interrelated and it is difficult to interpret the relevant data separately, the most significant factor affecting umbilical vein ADMA levels seems to be perinatal hypoxia as in the case of meconium staining.
The Turkish journal of pediatrics 51(2):141-5. · 0.56 Impact Factor