Publications (3)3.92 Total impact
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Article: Immunotherapy of allergic diseases using probiotics or recombinant probiotics.
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ABSTRACT: Allergic diseases affect up to 30% of the western population and their prevalence is increasing. Probiotics are able to modulate the mucosal immune response and clinical trials demonstrated that specific strains, especially Lactic Acid Bacteria (LAB) ones, reduce allergic symptoms. Moreover, the use of recombinant probiotics has been evaluated as possible strategies for the immunotherapy of allergic diseases. The production and delivery of allergens by recombinant LAB in concert with their ability to induce a Th1-type immune response have been shown to be a promising mucosal vaccination strategy in mouse model. Aim of this paper is to review the applications of probiotics in allergy immunotherapy with a special focus on recombinant LAB delivering proteins or DNA. © 2013 The Authors Journal of Applied Microbiology © 2013 The Society for AppliedMicrobiology.Journal of Applied Microbiology 02/2013; · 2.34 Impact Factor -
Article: Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems.
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ABSTRACT: Lactic acid bacteria (LAB), widely used in the food industry, are present in the intestine of most animals, including humans. The potential use of these bacteria as mucosal delivery vehicles for vaccinal, medical or technological use has been extensively investigated. Lactococcus lactis, a LAB species, is a potential candidate for the production of biologically useful proteins and for plasmid DNA delivery to eukaryotic cells. Several delivery systems have been developed to target heterologous proteins to a specific cell location (i.e., cytoplasm, cell wall or extracellular medium) and more recently to efficiently transfer DNA to eukaryotic cells. A promising application of L. lactis is its use for the development of live mucosal vaccines. Here, we have reviewed the expression of heterologous protein and the various delivery systems developed for L. lactis, as well as its use as an oral vaccine carrier.Protein Expression and Purification 06/2011; 79(2):165-75. · 1.59 Impact Factor -
Chapter: Lactic Acid Bacteria as Live Vectors: Heterologous Protein Production and Delivery Systems
03/2010: pages 161 - 176; , ISBN: 9780813820866
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Institutions
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2010–2013
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Federal University of Minas Gerais
- Instituto de Cîências Biológicas (ICB)
Belo Horizonte, Estado de Minas Gerais, Brazil
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