Publications (2)5.01 Total impact
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Article: Erratum to: Selective Interaction of Amyloid Precursor Protein with Different Isoforms of Neural Cell Adhesion Molecule.
Journal of Molecular Neuroscience 01/2012; · 2.50 Impact Factor -
Article: Selective interaction of amyloid precursor protein with different isoforms of neural cell adhesion molecule.
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ABSTRACT: Compare to the thoroughly studied beta-amyloid, the physiological function of amyloid precursor protein (APP) is not well understood. We now had identified neural cell adhesion molecule (NCAM)-140 as a potential interaction partner of APP. Our data indicated that NCAM-140, but not NCAM-180, binds to the conserved central extracellular domain of APP. We also found that the phosphorylation levels of ERK1 and ERK2 were increased when cells were co-transfected with NCAM-140 and APP indicate that the interaction between NCAM-140 and APP may involve the MAPK pathway. These findings demonstrated that NCAM-140 interacts with APP, potentially playing a role in neurite outgrowth and neural development.Journal of Molecular Neuroscience 06/2011; 46(1):203-9. · 2.50 Impact Factor
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Institutions
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2011–2012
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Southeast University (China)
Nanjing, Jiangxi Sheng, China
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