Chao Li

Publications (3)5.81 Total impact

• Article: Estrogen receptor-alpha promoter methylation in sporadic basal-like breast cancer of Chinese women.

  Ming-xi Jing, Xiao-yun Mao, Chao Li, Jing Wei, Chong Liu, Feng Jin
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  ABSTRACT: Basal-like breast cancer (BLBC) appears to be characterized by a relatively unfavorable prognosis and lack of a specific therapeutic target. Estrogen receptor-alpha (ERα) has been widely accepted as a prognostic marker and a predictor for endocrine therapy response of breast cancer. This study aimed to clarify the correlation of ERα methylation with the pathogenesis and clinicopathological significance of sporadic BLBC of Chinese women without a family history of the cancer. The methylation of ERα promoter was investigated in genomic DNA of 60 sporadic BLBC with 108 cases of non-BLBC as control by methylation-specific polymerase chain reaction. We also investigated the expression of p53, breast cancer gene (BRCA)-1, and BRCA-2 by immunohistochemistry and analyzed the correlation between ERα methylation and clinicopathological features of BLBC. ERα methylation was observed in 48 of 60 (80.0%) sporadic BLBC, which was significantly higher than in sporadic non-BLBC cancer (47/108, 43.5%; χ2=20.89, p<0.01). No correlation was found between the ERα methylation and age and menopausal status, while it was significantly associated with lymph node metastasis, tumor stage, nuclear p53 accumulation, and BRCA-1 and BRCA-2 expression in sporadic BLBC. The ERα methylation status in basal-like breast cancer was significantly higher than in sporadic non-basal-like breast cancer. It was associated with the lymph node metastasis, tumor stage, p53 nuclear accumulation, and BRCA-1 and BRCA-2 expression in BLBC. It may play an important role in BLBC pathogenesis.
  Tumor Biology 04/2011; 32(4):713-9. · 1.94 Impact Factor
• Article: Equivalent circuit method research of resonant magnetoelectric characteristic in magnetoelectric laminate composites using nonlinear magnetostrictive constitutive model

  Hao-Miao Zhou, Chao Li, Li-Ming Xuan, Jing Wei, Ji-Xiang Zhao
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  ABSTRACT: This paper analyzes the magnetoelectric (ME) response around the resonance frequency in the magnetostrictive/piezoelectric/magnetostrictive (MPM) magnetoelectric laminate composites. Following the equivalent circuit method and considering the mechanical loss, we select the nonlinear magnetostrictive constitutive model to present a novel explicit nonlinear expression for the resonant magnetoelectric (ME) coefficient of the magnetoelectric laminate composites. Compared with the experimental results, the predicted resonant ME coefficient of the explicit expression shows a good agreement both qualitatively and quantitatively. Also, when the electromechanical coupling factor of the piezoelectric material, k31p, is small, this explicit expression can be reduced to the existing model. On this basis, this paper considers and predicts the magnetoelectric conversion characteristics of the magnetoelectric laminate composites, calculates and analyzes the influences of the thickness ratio of magnetostrictive layer and piezoelectric material, bias magnetic field, and saturation magnetostrictive coefficient on the resonant ME coefficient. This research can provide a theoretical basis for the preparation of magnetoelectric devices with good magnetoelectric conversion characteristics, such as magnetoelectric sensors, energy harvesting transducers, microwave devices etc.
  Smart Materials and Structures 02/2011; 20(3):035001. · 2.09 Impact Factor
• Article: Numerical simulation of nonlinear magnetic–mechanical–electric coupling effect in laminated magnetoelectric composites

  Hao-Miao Zhou, Li-Ming Xuan, Chao Li, Jing Wei
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  ABSTRACT: Considering the significant nonlinear magnetoelectric (ME) characteristics in laminated ME composites, we build a numerical model of magnetic–mechanical–electric coupling effect based on the nonlinear magnetostrictive constitutive relation. The change of the ME field coefficients with bias magnetic field predicted by this model shows good agreement with the experimental result, both qualitatively and quantitatively. Furthermore, this paper considers and predicts the magnetoelectric conversion charateristics of laminated ME composites, calculates and analyzes the influence of the thickness ratio of magnetostrictive layer, the geometrical size of laminated composites, the saturation magnetization, and the types of piezoelectric materials on the ME conversion coefficient of ME laminated composites. We believe that this research provides a theoretical basis for the production of magnetoelectric devices with good magnetoelectric conversion characteristics.Highlights► Considering nonlinear magnetic–mechanical coupling of giant magnetostrictive materials. ► Presenting a nonlinear magnetic–mechanical–electric coupling model of ME composite. ► Revealing different changes in the ME coefficients of bilayered and trilayered structures.
  Journal of Magnetism and Magnetic Materials 323(22):2802-2807. · 1.78 Impact Factor